Ointment for treating dermatitis and eczema and preparation method thereof

A technology for eczema and ointment, which is applied in the direction of anti-inflammatory agents, medical preparations containing active ingredients, skin diseases, etc., can solve problems such as pigmentation, many side effects, and skin thinning, so as to improve compliance, reduce side effects, reduce skin irritating effects

Active Publication Date: 2016-06-22
江西省皮肤病专科医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The hydrocortisone butyrate ointment or cream circulating on the market are mostly unilateral preparations, wherein the content of hydrocortisone butyrate is generally 0.1%, although effective, the disadvantage of using steroid corticosteroids alone is that the side effects are relatively low. Many, such as skin thinning, muscle atrophy, acne, hirsutism, pigmentation, etc.

Method used

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  • Ointment for treating dermatitis and eczema and preparation method thereof
  • Ointment for treating dermatitis and eczema and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] An ointment for dermatitis and eczema, its composition is calculated by weight percentage, hydrocortisone butyrate 0.05%, menthol 2%, borneol 3.5%, laurocaprone 2%, glyceryl monostearate 7% , 8% cetyl alcohol, 10% white petrolatum, 3% liquid paraffin, 8% glycerin, Ping Pinga O 6%, 800.5% Tween, 8% propylene glycol, 0.5% citric acid, 0.02% sodium citrate, hydroxyl 0.05% phenethyl ester, appropriate amount of purified water.

[0024] Accurately weighed according to the above ratio, the preparation method of the cream is as follows: (1) Oil phase preparation: Mix glyceryl monostearate, cetyl alcohol, white petrolatum, and liquid paraffin, heat and melt to form a solution, and keep the temperature at 85°C ; (2) Preparation of water phase: Mix glycerin, Pingpingjia O, Tween 80, propylene glycol, citric acid, sodium citrate, ethylparaben, and purified water, then heat and keep the temperature at 80°C; (3) Convergence: slowly add the oil phase prepared in step (1) into the wa...

Embodiment 2

[0026] An ointment for dermatitis and eczema, its composition is by weight percentage, hydrocortisone butyrate 0.06%, camphor 2.5%, borneol 2.5%, laurocaprone 2.5%, glyceryl monostearate 8%, Cetyl Alcohol 8%, White Petrolatum 12%, Liquid Paraffin 7%, Glycerin 10%, Pinga O5%, Tween 801.5%, Propylene Glycol 10%, Citric Acid 0.5%, Sodium Citrate 0.02%, Ethylparaben 0.08% ester, appropriate amount of purified water.

[0027] Accurately weighed according to the above ratio, the preparation method of the cream is as follows: (1) Oil phase preparation: Mix glyceryl monostearate, cetyl alcohol, white petrolatum, and liquid paraffin, heat and melt to form a solution, and keep the temperature at 82°C ; (2) Preparation of water phase: Mix glycerin, Pingpingjia O, Tween 80, propylene glycol, citric acid, sodium citrate, ethylparaben, and purified water, then heat and keep the temperature at 80°C; (3) Convergence: slowly add the oil phase prepared in step (1) into the water phase prepared...

Embodiment 3

[0029] An ointment for dermatitis and eczema, its composition is calculated by weight percentage, hydrocortisone butyrate 0.08%, menthol 2.5%, camphor 2.5%, laurocaprone 3%, glyceryl monostearate 8% , 10% cetyl alcohol, 10% white petrolatum, 8% liquid paraffin, 10% glycerin, 8% Ping Pinga O, 803% Tween, 8% propylene glycol, 0.45% citric acid, 0.03% sodium citrate, hydroxybenzene 0.1% ethyl ester, appropriate amount of purified water.

[0030] Accurately weighed according to the above ratio, the preparation method of the cream is as follows: (1) Oil phase preparation: Mix glyceryl monostearate, cetyl alcohol, white petrolatum, and liquid paraffin, heat and melt to form a solution, and keep the temperature at 80°C ; (2) Preparation of water phase: Mix glycerin, Pingpingjia O, Tween 80, propylene glycol, citric acid, sodium citrate, ethylparaben, and purified water, then heat and keep the temperature at 80°C; (3) Convergence: slowly add the oil phase prepared in step (1) into th...

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Abstract

The invention relates to a medicine composition for treating dermatitis, eczema and other skin diseases, in particular to an ointment with hydrocortisone butyrate as an active ingredient. The ointment for treating the dermatitis and eczema contains the hydrocortisone butyrate serving as the active ingredient and further contains any component of menthol, camphor and borneol serving as active ingredients and the balance ointment matrix. Compared with the prior art, the ointment has the following advantages that the side effects of the hydrocortisone butyrate are reduced, skin irritation is relieved, the itching, pain and swell relieving effect is remarkably improved, and the medication compliance of patients is obviously improved.

Description

technical field [0001] The invention relates to a medicine combination for treating skin diseases such as dermatitis and eczema, in particular to an ointment with hydrocortisone butyrate and the like as active components. Background technique [0002] Hydrocortisone butyrate is a medium-effect steroidal glucocorticoid, which can inhibit local vasodilation, reduce capillary permeability, inhibit the inflammatory response caused by lymphokines, and inhibit skin delayed allergic reactions. Anti-inflammatory, anti-allergic, immunosuppressive and other effects, and has a significant anti-inflammatory effect on skin diseases caused by non-infection. External application is mainly used for skin diseases such as allergic dermatitis, seborrheic dermatitis, eczema, and lichen simplex chronicus. [0003] The hydrocortisone butyrate ointment or cream circulating on the market are mostly unilateral preparations, wherein the content of hydrocortisone butyrate is generally 0.1%, although ...

Claims

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Application Information

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IPC IPC(8): A61K31/573A61K31/045A61K31/125A61K31/55A61K9/06A61K47/06A61P17/00A61P17/04A61P17/08A61P29/00A61P37/08A61P37/06
CPCA61K47/06A61K9/0014A61K9/06A61K31/045A61K31/125A61K31/55A61K31/573A61K2300/00
Inventor 罗美兰耿承芳熊兴龙王小兵
Owner 江西省皮肤病专科医院
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