Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Application of Eupatilin in preparation of pulmonary fibrosis resistant drugs

A technology for eupholzanthin and pulmonary fibrosis, which is applied in the field of natural chemical substances, can solve problems such as the application of eupholzanthin that have not been reported yet, and achieve the effect of wide practical value and clear pharmacological activity

Inactive Publication Date: 2016-06-15
CHINA PHARM UNIV
View PDF3 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] At present, there is no report on the effect of eupholzanthin on improving pulmonary fibrosis and its application in drugs for the treatment of pulmonary fibrosis

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of Eupatilin in preparation of pulmonary fibrosis resistant drugs
  • Application of Eupatilin in preparation of pulmonary fibrosis resistant drugs
  • Application of Eupatilin in preparation of pulmonary fibrosis resistant drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] 1. Preparation and structure confirmation of eupholzanthin

[0044] Artemisia argyi Levl. et Vamt. is the dried leaf of Artemisia argyi Levl. et Vamt., purchased from Anguo, Hebei. Dry Artemisia argyi 10kg, heat and reflux extract 3 times with 70% ethanol solution by volume fraction, combine, recover the solvent under reduced pressure, concentrate the obtained aqueous solution and extract with petroleum ether, chloroform, ethyl acetate, n-butanol respectively. 100.0 g of the chloroform extraction layer was eluted through silica gel column chromatography with chloroform-methanol (100:0-0:100) as the mobile phase to obtain 5 fractions A-E, and fraction B was eluted through silica gel column chromatography with chloroform-methanol (100:0-0- 2:1) was used as the mobile phase for elution to obtain 3 fractions a, b, and c. Fraction a was prepared by recrystallization to obtain eupholzanthin. The physical and chemical properties and spectral data are as follows: yellow powde...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to application of a chemical substance Eupatilin for treating pulmonary fibrosis. The compound Eupatilin is obtained from traditional Chinese medicine Folium Artemisiae Argyi, the structure of the Eupatilin is determined according to spectrum data, the fibrosis degree of lung tissues of model mice is improved obviously after intragastric administration of the Eupatilin, NO content and MDA content which reflect lung damage degree are reduced, HYP content reflecting lung tissue collagen deposition is lowered, and the content of cell factor TGF-beta 1 causing the pulmonary fibrosis is decreased; human embryonic lung fibroblast proliferation and HYP content are inhibited in vitro. In-vivo and in-vitro experiments show that the Eupatilin can remarkably improve bleomycin induced pulmonary fibrosis of the mice, and can be applied to drugs for treating the pulmonary fibrosis.

Description

technical field [0001] The invention relates to a new application of a natural chemical substance eupholzanthin as a drug for treating pulmonary fibrosis. Background technique [0002] Pulmonary fibrosis (PF) is a chronic interstitial lung disease with insidious onset, rapid progression, high mortality and poor treatment effect. Deposition in the pulmonary interstitium is characteristic. Pulmonary fibrosis is caused by various pathogenic factors inside and outside the lungs, and is the result of a series of chronic lung injuries or the development of advanced diseases, which seriously endangers human health. [1] . [0003] The pathogenesis of pulmonary fibrosis has not yet been fully clarified. The research theory generally involves these four aspects, including inflammatory cell imbalance, cytokine secretion and response imbalance, signal transduction mechanism, and lipid peroxidation. A process in which multiple factors and multiple links participate in each other. Its...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K31/352A61P11/00A61K36/282
CPCA61K31/352A61K36/282
Inventor 张朝凤陶丽君曹娟
Owner CHINA PHARM UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com