Modular Vent

A ventilation device, gas technology, applied in mixers with rotary stirring devices, biochemical instruments, transportation and packaging, etc., can solve the problems of ineffectiveness, expensive sterilization procedures, troublesome, etc., to reduce complexity, reduce mold cost, The effect of promoting proper growth

Active Publication Date: 2021-07-13
MILLIPORE CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Sterilization procedures are expensive, cumbersome, and sometimes ineffective

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0059] A series of K L A Test is operated in a 1000L vessel mounted with a 13 "round impeller, baffle and suitable sensor to establish relationships between the area of ​​the gas permeable material in the modular bubble mixer and the expected gas transfer efficiency. For these Test, impeller RPM at 60 rpm, 10 w / m 3 The power input is kept constant. in figure 1 Modular flying bubble mixer in all four locations using Tyvek ® 1059B as a gas permeable material and uses air flow rate from 5 lpm to 20 lpm (from 0.005 to 0.020 min) -1 The air flow rate (VVM)) runs three repetition tests under each condition. The full-size bubble mixer is also tested. Using an analog medium, it consists of water, Prangnik (0.2%), 1X PBS and 50 ppm foamed. The result is shown Figure 7 in. Data indicates that higher air flow rate leads to higher K L a value.

[0060] Can pass K L The A / area / VVM compares the area of ​​each modular segment of the bubble stirre to determine the gas transfer efficiency. F...

example 2

[0064] The modular bubble stirrer according to the embodiments disclosed herein allows more than one type of gas permeable material to be used in the system. Example 1 Prove that high K L a value, where Tyvek ® The material only occupies two modular segments in the four modular segments of the bubble mixer. For example, a gas permeable material for the remaining two modular segments can be selected to produce a ratio than using Tyvek. ® Materials generated with larger bubbles, such as Porex ® POR97619 ("PE-10"), POR4920 ("PE-40") and POR 4903 ("PE-90"), all of which are made of polyethylene.

[0065] The three types of gas permeable materials were evaluated in one and two segments from 5 lpm to 50 lpm (0.005 VVM to 0.05 VVM) in an air flow rate of 5 lpm to 50 lpm (0.005 VVM to 0.05 VVM), of which the impeller is evaluated in one and two segments of the bubbubble stirrer. RPM remains constant at 60 rpm. Summary Figure 11 in.

[0066] Generally, larger aperture size (PE-90) material...

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PUM

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Abstract

The present invention relates to an aeration device and a container or vessel incorporating it. The aeration device may include a plurality of interchangeable aeration elements that generate and transport air bubbles of different sizes to the contents of the container. Also disclosed are containers, such as disposable or single-use containers, optionally having one or more inlets and one or more outlets, venting means including a plurality of venting elements, and means to cause A mixer for mixing, dispersing, homogenizing and / or circulating one or more ingredients. The vessel may be a bioreactor, and the aeration means controls the dissolved gas concentration level of the contents of the bioreactor to promote proper growth of the cell culture in the bioreactor.

Description

[0001] The present application claims priority to the US Provisional Application Serial No. 61 / 897, 246, filed on October 30, 2013, which is incorporated herein by reference. Technical field [0002] Embodiments disclosed herein relate to modular ventilation devices that can be used in containers or vessels, such as bioreactors, and in particular a single-use mixing tank bioreactor, and relate to a modular ventilation device and Hybrid components, and a container or utensil containing it. Background technique [0003] Traditionally, fluids such as biomaterials are treated in systems such as stainless steel containers or vessels. These containers are sterilized after use so that they can be reused. The sterilization process is expensive and troublesome, and sometimes it is invalid. [0004] To provide greater flexibility in the manufacturing process and reduce the effective regeneration of the equipment, the manufacturer has begun to use a disposable sterilization container with pr...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01F3/04B01F27/91B01F33/40
CPCC12M29/06C12M27/02B01F23/23124B01F23/231262B01F23/233B01F23/23351B01F23/23362B01F27/91B01F33/4534B01F35/2132B01F35/2211B01F35/513B01F2101/44C12Q3/00
Inventor A.伍德D.克劳斯A.汉森K.德尔J.麦克斯维尼
Owner MILLIPORE CORP
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