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Chromium (III) complex as well as preparation method and application thereof

A complex and chromium salt technology, applied in the field of metal complexes, can solve problems such as chromosome damage, low intestinal absorption rate, DNA mutation, etc., and achieve moderate stability and good water solubility

Inactive Publication Date: 2016-05-25
SHANXI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, recent literature reports: chromium picolinate may cause chromosomal damage, DNA mutation and cancer, and the intestinal absorption rate is low (<3%), its use has gradually aroused people's doubts

Method used

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  • Chromium (III) complex as well as preparation method and application thereof
  • Chromium (III) complex as well as preparation method and application thereof
  • Chromium (III) complex as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Embodiment 1: Preparation and structural characterization of chromium (III) complexes

[0021] Weigh 2.67g (10.0mmol) CrCl 3 ·6H 2 O and 1.52g (10.0mmol) 3-methyl-salicylic acid (3-CH 3 -SA), placed in a 100mL round-bottomed flask, dissolved in 50mL of methanol, then added 0.30g of arsenic-free Zn particles, heated to reflux for 1 hour, then slowly added 0.5mL of triethylenetetramine (Trientine), until the color of the solution changed from The green color gradually changed to red, and the reaction was continued for 1 hour, cooled, filtered with suction, and the filtrate was naturally volatilized at room temperature, and red crystals were obtained after three days, with a yield of 60%.

[0022] Elemental analysis results, from the molecular formula CrC 14 h 26 N 4 o 4 Cl Theoretical (%): C, 41.79; H, 6.47; N, 13.93; Experimental (%): C, 41.55; H, 6.69; N, 13.88.

[0023] Crystal structure determination results (see attached figure 1 ): The molecular formula of t...

Embodiment 2

[0028] Embodiment 2: the preparation of chromium (III) complex

[0029] Weigh 2.67g (10.0mmol) CrCl 3 ·6H 2 O and 1.52g (10.0mmol) 3-methyl-salicylic acid were placed in a 100mL round-bottomed flask, 50mL of ethanol was added, and 1.0g of arsenic-free zinc particles were added, stirred and heated under reflux for 2 hours, and 1mL of triethylene tetra Amine, the color of the solution slowly changed from green to red, continued stirring and heating under reflux for about 2 hours, cooled, and naturally volatilized at room temperature. After 3 days, red crystals were obtained with a yield of 75%.

Embodiment 3

[0030] Embodiment 3: the application of hypoglycemic and weight loss activity of chromium (III) complex

[0031] The hypoglycemic and weight-reducing activity of the chromium (III) complex was verified by feeding mice. The mice used in the experiment were provided by the Experimental Animal Center of Shanxi Academy of Traditional Chinese Medicine. We selected 48 Kunming mice, half male and half male, body weight range 12-15g; room temperature 15-25°C, relative humidity 30%-40%, natural light, free to eat and drink. Common feed was provided by Beijing Suolaibao Technology Co., Ltd. High-fat feed formula: 66.5% of common food, 20% of sucrose, 10% of lard, 2.5% of cholesterol and 1% of sodium cholate. The mice were randomly divided into 4 groups according to body weight, including 12 in the normal group, 12 in the model group, 12 in the positive control group, and 12 in the drug treatment group. From the beginning of the experiment, the mice in the normal group were given norm...

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Abstract

The invention provides a chromium (III) complex as well as a preparation method and application thereof. According to the chromium (III) complex, the molecular formula is CrC14H26N4O4Cl, the molecular weight is 402, the crystal structure belongs to a triclinic crystal system, the spatial point group is P-1, a is equal to 7.8880(6), b is equal to 9.8380(7), c is equal to 14.4490(12) angstroms, alpha is equal to 70.4550(10), beta is equal to 85.729(2), gamma is equal to 82.0880(10) degrees, V is equal to 1046.12(14) cubic angstroms, and Z is equal to 2. The preparation method comprises the steps of dissolving chromium (III) and 3-methyl-salicylic acid by virtue of an organic solvent, feeding a small amount of zinc granules, carrying out heating reflux, then dropwise adding triethylene tetramine, continuing to carry out reflux for a period of time, stopping reaction, cooling, filtering, standing obtained filtrate, and naturally volatilizing at the normal temperature, so as to obtain purple red crystals. The chromium (III) complex can be applied to the preparation of sugar-reducing medicines.

Description

Technical field: [0001] The invention relates to a metal complex, specifically a chromium (III) complex based on 3-methyl-salicylic acid and triethylenetetramine as a mixed ligand, a preparation method and application thereof. Background technique: [0002] Chromium is an essential trace element for the human body. Trivalent chromium is an element beneficial to the human body. However, the physiological function of chromium is to work together with other substances that control metabolism, such as hormones, insulin, various enzymes, and genetic material (DNA and RNA) of cells. Studies have shown that chromium is significantly reduced in diabetic patients, and chromium levels are negatively correlated with blood sugar. Chromium (III) content in the human body gradually decreases with age, and chromium (III) deficiency can reduce the sensitivity of tissues to insulin, making people prone to diabetes and atherosclerosis. Supplementing a proper amount of chromium (III) to diab...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07F11/00A61P3/10A61P3/04A61P3/06
CPCC07B2200/13C07F11/005
Inventor 刘斌周海乐董金龙杨斌盛
Owner SHANXI UNIV
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