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Use of dianhydrogalactitol and analogs and derivatives thereof to treat recurrent malignant glioma or progressive secondary brian tumor

A technology of anhydrogalactitol and glioma, which is applied in the determination/examination of microorganisms, nervous system diseases, biochemical equipment and methods, etc., and can solve problems such as critical needs, difficult cancer treatment, and exhaustion of patient treatment options

Inactive Publication Date: 2016-05-11
DEL MAR PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because of the difficult treatment of cancer, patients' treatment options are often quickly exhausted creating an urgent need for additional treatment options

Method used

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  • Use of dianhydrogalactitol and analogs and derivatives thereof to treat recurrent malignant glioma or progressive secondary brian tumor
  • Use of dianhydrogalactitol and analogs and derivatives thereof to treat recurrent malignant glioma or progressive secondary brian tumor
  • Use of dianhydrogalactitol and analogs and derivatives thereof to treat recurrent malignant glioma or progressive secondary brian tumor

Examples

Experimental program
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preparation example Construction

[0772] (e) Preparation with lower residual solvent content; and

[0773] (f) Preparation of lower residual heavy metal content.

[0774] Where improvement is achieved through the use of a diluent, the diluent may be, but is not limited to, a diluent selected from the group consisting of:

[0775] (a) emulsions;

[0776] (b) dimethylsulfoxide (DMSO);

[0777] (c) N-methylformamide (NMF);

[0778] (d) Dimethylformamide (DMF);

[0779] (e) Dimethylacetamide (DMA);

[0780] (f) ethanol;

[0781] (g) benzyl alcohol;

[0782] (h) Glucose-containing water for injection;

[0783] (i) castor oil polyoxyethylene ether;

[0784] (j) cyclodextrins; and

[0785] (k) PEG.

[0786] Where improvements are achieved through the use of a solvent system, the solvent system may be, but is not limited to, a solvent system selected from the group consisting of:

[0787] (a) emulsions;

[0788] (b) DMSO;

[0789] (c) NMF;

[0790] (d) DMF;

[0791] (e) DMA;

[0792] (f) ethanol;

[0...

Embodiment

[1306] Treatment of patients with recurrent malignant glioma or progressive secondary brain tumors with dianhydrogalactitol

[1307] Brain tumors are among the most therapeutically challenging malignancies. The median survival of patients with recurrent disease of glioblastoma multiforme (GBM) is <6 months. Tumors that have spread to the brain, central nervous system (CNS) metastases have developed into a major contributor to cancer mortality based on the inability of improved systemic therapy to reach tumors.

[1308] The first-line systemic therapy is temozolomide but due to O 6- Resistance to methylguanine-DNA methyltransferase (MGMT) activity has been implicated in adverse outcomes. Such resistance greatly reduces survival rates.

[1309] Dianhydrogalactitol is a novel bifunctional N that easily crosses the blood-brain barrier and accumulates in brain tissue 7 DNA-alkylating agent. Dianhydrogalactitol causes cross-linking of DNA strands at N 7 - Guanine (E. Institóri...

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PUM

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Abstract

Methods and compositions suitable for the treatment of malignancies such as recurrent glioma and progressive secondary brain tumor are disclosed. These methods employ a hexitol derivative such as dianhydrogalactitol, a derivative or analog of dianhydrogalactitol, diacetyldianhydrogalactitol, or a derivative or analog of diacetyldianhydrogalactitol. The compositions can include such hexitol derivatives.

Description

[0001] [Citation to Related Application] [0002] This application asserts U.S. Provisional Patent Application Serial No. 61 / 829,739 filed on May 31, 2013 by K.C.Shi et al. Uses for gliomas or progressive secondary brain tumors". This application is incorporated herein by reference in its entirety. technical field [0003] The present invention is directed to methods and compositions comprising dianhydrogalactitol or its analogs or derivatives for treating malignant glioma or progressive secondary brain tumor. Background technique [0004] For many of the life-threatening diseases that afflict mankind, the research and identification of cures are still a process of experience and sometimes chance. Although there have been many advances from basic scientific research to improvements in actual patient management, there is still a great setback in the rational and successful discovery of effective therapies, especially for life-threatening diseases such as cancer, inflammatio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7024
CPCA61K45/06A61K31/336A61P25/00A61P35/00A61P43/00A61K2300/00C12Q2600/156G01N33/6893C12Q1/6827C12Q1/6883A61K9/0053A61K9/0019
Inventor D·M·布朗K·C·施A·斯坦斯R·施瓦兹S·肯纳卡H·A·伯三世J·帕夏W·加纳
Owner DEL MAR PHARMA
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