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Eczematous dermatitis prevention medicine, and preparation method and application thereof

A technology for dermatitis, eczema and medicine, which is applied in the field of medicine and preparation, can solve the problems of unsatisfactory treatment effect and obvious side effects, and achieve the effect of wide extraction range, fast drug release and strong penetrating power

Inactive Publication Date: 2016-05-11
XIAN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to provide a kind of medicine that is used for anti-dermatitis eczema, has solved the problem that existing medicine treatment effect is unsatisfactory and side effect is obvious

Method used

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  • Eczematous dermatitis prevention medicine, and preparation method and application thereof
  • Eczematous dermatitis prevention medicine, and preparation method and application thereof
  • Eczematous dermatitis prevention medicine, and preparation method and application thereof

Examples

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Effect test

preparation example Construction

[0023] The preparation method of the above-mentioned medicine for anti-dermatitis eczema specifically implements according to the following steps:

[0024] Step 1, weighing 16% to 24% of purslane, 16% to 24% of honeysuckle, 0.5% to 1.2% of carbomer 9400, 0.8% to 2.5% of azone enhancer, and 0.8% to 4% of propylene glycol according to mass percentage %, glycerol 2% to 16%, the balance is water, and the sum of the mass percentages of the above components is 100%;

[0025] Step 2, purslane and honeysuckle are crushed into coarse powder, purslane is extracted with 8 times the amount of 80% ethanol continuously under reflux until the siphon is colorless, and honeysuckle is continuously extracted with 6 times the amount of 60% ethanol until the siphon is colorless, and then After recovering the solvent of the extract solution, add water and mix well to form a mixed solution. Sprinkle Carbomer 940 evenly on the surface of the mixed solution, let it sit overnight to make it fully swell...

Embodiment 1

[0076] Step 1, take purslane 16%, honeysuckle 20%, carbomer 9400.8%, penetration enhancer azone 2.5%, propylene glycol 0.8%, glycerol 2% respectively by mass percentage, and the balance is water, the above group The sum of the sub-mass percentages is 100%;

[0077] Step 2, purslane and honeysuckle are crushed into coarse powder, purslane is extracted with 8 times the amount of 80% ethanol continuously under reflux until the siphon is colorless, and honeysuckle is continuously extracted with 6 times the amount of 60% ethanol until the siphon is colorless, and then After recovering the solvent of the extract solution, add water and mix well to form a mixed solution. Sprinkle Carbomer 940 evenly on the surface of the mixed solution, let it sit overnight to make it fully swell, then add glycerol, propylene glycol, azone as a penetration enhancer, and finally use triethanolamine Adjust the pH to 6.8-7.0, that is.

Embodiment 2

[0079] Step 1, take by weight percentage of purslane 20%, honeysuckle 24%, carbomer 9401.2%, penetration enhancer azone 0.8%, propylene glycol 2.5%, glycerol 16%, the balance is water, the above group The sum of the sub-mass percentages is 100%;

[0080] Step 2, purslane and honeysuckle are crushed into coarse powder, purslane is extracted with 8 times the amount of 80% ethanol continuously under reflux until the siphon is colorless, and honeysuckle is continuously extracted with 6 times the amount of 60% ethanol until the siphon is colorless, and then After recovering the solvent of the extract, add water and mix well to form a mixed solution. Sprinkle Carbomer 940 evenly on the surface of the mixed solution, let it sit overnight to make it fully swell, then add glycerin, propylene glycol, azone as a penetration enhancer, and finally use triethanolamine Adjust the pH to 6.8-7.0, that is.

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Abstract

The invention discloses an eczematous dermatitis prevention medicine, and a preparation method and an application thereof. The medicine mainly comprises, by mass, 16-24% of purslane, 16-24% of honeysuckle flower, 0.5-1.2% of carbomer 940, 0.8-2.5% of azone, 0.8-4% of propylene glycol, 2-16% of glycerol, and the balance of water, and the sum of mass percentages of above components is 100%. The czematous dermatitis prevention medicine is uniform and fine; the medicine has good biocompatibility, so a transparent film can be formed after the medicine is coated on skins, and can be closely adhered to an action position for a long time; and the medicine has the advantages of good bio-adherence, fast medicine release, long detention time, easy absorption and no tight coverage after local administration, oily feeling, easy washing removal, no pollution to clothes, good stability, generation of sustained release, controlled release and pulsed release of medicine effects, no irritation to skins or mucous membranes, comfortable use, and suitableness for local external use on skins.

Description

technical field [0001] The invention belongs to the field of medicine and preparation technology, and in particular relates to a medicine for resisting dermatitis and eczema, and also relates to a preparation method and application of the medicine. Background technique [0002] Dermatitis eczema is a common recurrent chronic skin disease in clinical practice. It is a hypersensitive inflammatory skin disease with a high incidence rate. It shows that 10.7% of the respondents suffer from eczema; in the same year, the prevalence rate of eczema in the general population of our community was 7.5%; the prevalence rate in our country is relatively low, but it also has a gradually increasing trend. The course of the disease is longer. The prognosis of this disease is poor, 85% recurs, it is difficult to cure, the etiology is complex, the treatment is difficult, and the patient's itching is obvious, which seriously affects the quality of life of the patient. [0003] At present, the...

Claims

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Application Information

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IPC IPC(8): A61K36/355A61P17/00
CPCA61K47/32A61K9/7015A61K36/185A61K36/355A61K2236/333A61K2300/00
Inventor 扈本荃张宇洁徐玥
Owner XIAN MEDICAL UNIV
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