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Application of novel SGK1 inhibitor EMD638683 in preparation of drug used for treating acute myocardial infarction

A technology of 1.EMD638683 and 6.EMD638683, applied in the direction of drug combination, pharmaceutical formula, organic active ingredients, etc., can solve the complex and precise regulation mechanism of the inflammatory immune system, achieve good development and application prospects, and reduce the effect of heart rupture

Inactive Publication Date: 2016-05-11
BEIJING ANZHEN HOSPITAL AFFILIATED TO CAPITAL MEDICAL UNIV
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Problems solved by technology

However, the regulatory mechanism of the inflammatory immune system is extremely complex and precise. Non-specific suppression of the immune inflammatory response after myocardial infarction, such as the use of glucocorticoids, will undoubtedly produce unpredictable serious consequences and complications
So far, inflammatory immunomodulatory drugs have not been used clinically in the treatment of myocardial infarction

Method used

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  • Application of novel SGK1 inhibitor EMD638683 in preparation of drug used for treating acute myocardial infarction
  • Application of novel SGK1 inhibitor EMD638683 in preparation of drug used for treating acute myocardial infarction
  • Application of novel SGK1 inhibitor EMD638683 in preparation of drug used for treating acute myocardial infarction

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Embodiment 1

[0044] Example 1, the application of EMD638683 in the treatment of myocardial infarction mice

[0045] 1. Establishment of myocardial infarction model in mice

[0046] According to conventional methods, the myocardial infarction model in mice was established by ligation of the left anterior descending coronary artery. The specific operation is as follows: the mouse anesthetized with isoflurane was fixed supine on the mouse board, and a 1.5 cm incision was made at the third and fourth intercostal spaces of the mouse heart along the line connecting the armpit and the lower end of the sternum. -4 The intercostal space was pierced, the heart was quickly squeezed out with the left hand, and the pericardium was peeled off. With the horizontal line of the lower edge of the left atrial appendage as a mark, the coronary artery was ligated with 6-0 proline silk thread 2 mm below the line, and the depth of the needle was about 1 mm to avoid puncturing the heart. After the ligation, the...

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Abstract

The invention discloses application of EMD638683 in protection of the heart suffering from acute myocardial infarction. The invention provides application of EMD638683 in preparation of products having the following functions: 1) prevention and / or treatment of myocardial infarction of animals; 2) prevention and / or treatment of heart failure caused by myocardial infarction of animals; and 3) inhibition of the expression of SGK1 protein in cardiac muscle tissue after myocardial infarction of animals. Experimental results of the invention prove that EMD638683 has treatment effect on mice with myocardial infarction, and experimental data is provided for clinical application of EMD638683 in treatment of myocardial infarction. The EMD638683 is of important theoretical significance to research on and development of medicines used for preventing and treating heart failure caused by myocardial infarction and has good application prospects.

Description

technical field [0001] The invention relates to the field of biotechnology, in particular to the application of a novel SGK1 inhibitor EMD638683 in the preparation of drugs for treating acute myocardial infarction. Background technique [0002] Worldwide, myocardial infarction (myocardial infarction, MI) has been one of the leading causes of human hospitalization and death. With economic and social development and changes in people's lifestyles, the prevalence and incidence of myocardial infarction in my country are increasing year by year, and the mortality rate is also higher than that in European and American countries. Myocardial infarction has become an important disease that endangers the lives of the people in our country because it is difficult to prevent, has an urgent onset, and has a dangerous prognosis. In recent years, with the continuous application of interventions such as interventional therapy and drug thrombolysis and anticoagulation in the treatment of ca...

Claims

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Application Information

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IPC IPC(8): A61K31/166A61P9/10A61P9/04
Inventor 杨敏杜杰张俊蒙任京媛刘婷婷
Owner BEIJING ANZHEN HOSPITAL AFFILIATED TO CAPITAL MEDICAL UNIV
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