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Pharmaceutical composition for treating pancreatic cancer and preparation method thereof

A composition and technology for pancreatic cancer, applied in drug combinations, pharmaceutical formulas, medical preparations containing active ingredients, etc., can solve problems such as p53-induced apoptosis

Inactive Publication Date: 2016-05-04
JINAN XINGYI MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

And it has been reported that the activation of p38MAPK pathway can lead to p53-induced apoptosis

Method used

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  • Pharmaceutical composition for treating pancreatic cancer and preparation method thereof
  • Pharmaceutical composition for treating pancreatic cancer and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Example 1: Pharmaceutical composition for treating pancreatic cancer and its preparation method

[0039] The composition and parts by weight of the raw material drug of the pharmaceutical composition for treating pancreatic cancer are: saikosaponin C 245g magma iguana 365g dandaozicai 4700g wet raw hypericin B 186g papiliodin acetate 150g dongbeiguanzhongsu 125g;

[0040] Preparation:

[0041] (1) According to the proportion of raw materials, take saikosaponin C, magma iguana, dandaozicai, hypericin B, tricherin acetate, and Dongbeiguanzhongsu, mix well, and use the weight Ethanol with a concentration of 43% is used as a solvent, and extracted by warm soaking at 34°C. The number of extractions is 10 times, and the extraction time is 13 hours each time. The amount of solvent used each time is 32 times the total weight of the raw material drug. Extract solution A, recover ethanol from extract solution A, concentrate to a relative density of 1.13, filter, the drug soluti...

Embodiment 2

[0044] Example 2: Pharmaceutical composition for treating pancreatic cancer and preparation method thereof

[0045] The composition and parts by weight of the raw material drug of the pharmaceutical composition for treating pancreatic cancer are: saikosaponin C 30g magma iguana 380g dandaozicai 4600g wet raw hypericin B 188g densiflorin acetate 140g dongbeiguanzhongsu 130g;

[0046] Preparation:

[0047] (1) According to the proportion of raw materials, take saikosaponin C, magma iguana, dandaozicai, hypericin B, tricherin acetate, and Dongbeiguanzhongsu, mix well, and use the weight Ethanol with a concentration of 43% is used as a solvent, and extracted by warm soaking at 34°C. The number of extractions is 10 times, and the extraction time is 13 hours each time. The amount of solvent used each time is 32 times the total weight of the raw material drug. Extract solution A, recover ethanol from extract solution A, concentrate to a relative density of 1.13, filter, the drug so...

Embodiment 3

[0050] Example 3: Pharmaceutical composition for treating pancreatic cancer and its preparation method

[0051] The composition and parts by weight of the raw material drug of the pharmaceutical composition for treating pancreatic cancer are: saikosaponin C 260g magma iguana 350g dandaozicai 4800g wet raw hypericin B 180g densiflorin acetate 160g dongbeiguanzhongsu 120g;

[0052] Preparation:

[0053] (1) According to the proportion of raw materials, take saikosaponin C, magma iguana, dandaozicai, hypericin B, tricherin acetate, and Dongbeiguanzhongsu, mix well, and use the weight Ethanol with a concentration of 43% is used as a solvent, and extracted by warm soaking at 34°C. The number of extractions is 10 times, and the extraction time is 13 hours each time. The amount of solvent used each time is 32 times the total weight of the raw material drug. Extract solution A, recover ethanol from extract solution A, concentrate to a relative density of 1.13, filter, the drug solut...

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Abstract

The invention discloses a pharmaceutical composition for treating a pancreatic cancer and a preparation method thereof. The pharmaceutical composition is prepared by taking saikoside C, agama himalayana, mazus stachydifolius, uliginosin B, erioflorin acetate and dryocrassin as bulk pharmaceuticals in proportion. The pharmaceutical composition can be prepared into various preparation forms according to a conventional preparation technology and is significant in pancreatic cancer treatment effect.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a pharmaceutical composition for treating pancreatic cancer and a preparation method thereof. Background technique [0002] Pancreatic cancer is a highly malignant tumor, and its death rate is the fourth among malignant tumors. Although treatment methods such as chemotherapy, radiotherapy, immunotherapy and surgery have made some progress in the past 5 years, only about 20% of patients survived for more than 1 year after diagnosis, and the overall 5-year survival rate of patients was only 5%. %. At present, traditional Chinese medicine is one of the non-surgical treatment approaches for the treatment of advanced pancreatic cancer. Because traditional Chinese medicine has less adverse reactions and good curative effect in the treatment of tumors, it has great potential and advantages in the prevention and treatment of pancreatic cancer, and it i...

Claims

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Application Information

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IPC IPC(8): A61K36/80A61P35/00A61K35/583A61K31/365A61K31/7048A61K31/352A61K31/122
CPCA61K36/80A61K9/2031A61K9/2059A61K9/4866A61K31/122A61K31/352A61K31/365A61K31/7048A61K35/583A61K2236/333A61K2236/39A61K2236/51A61K2236/53A61K2236/55
Inventor 不公告发明人
Owner JINAN XINGYI MEDICAL TECH
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