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Synbiotic microcapsules and preparing method and application thereof

A technology of synbiotics and microcapsules, applied in the biological field, can solve the problems of difficult to show anti-inflammatory effect, no formation of spores, loss of probiotic effect, etc., and achieve the effect of exerting active protection and promoting growth and development

Inactive Publication Date: 2016-05-04
魏永刚
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, Saccharomyces bradymi does not form spores during the growth process, and has poor stress resistance, so it is difficult to store for a long time under liquid conditions
In the body, as exogenous bacteria, they are greatly affected by the environment of the gastrointestinal tract and easily lose their activity, thus losing their probiotic effects, and their anti-inflammatory effects are also difficult to show

Method used

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  • Synbiotic microcapsules and preparing method and application thereof
  • Synbiotic microcapsules and preparing method and application thereof
  • Synbiotic microcapsules and preparing method and application thereof

Examples

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Embodiment 1

[0034] Such as figure 1 and figure 2 As shown, the present invention provides a synbiotic microcapsule, including a capsule material and a wall material, the wall material includes liquid paraffin and Span80, and the capsule material contains soybean polypeptide and Brady's yeast.

[0035] Its preparation method comprises the following steps:

[0036] (1) Preparation of microcapsule capsule material solution: prepare a sodium alginate solution with a concentration of 0.8g / L, and sterilize it for subsequent use; add CaCO to the obtained sodium alginate solution 3 , to CaCO 3 The concentration is up to 1.0g / L, and after mixing evenly, a sodium alginate-calcium carbonate composite aqueous solution is obtained.

[0037] Add the soybean polypeptide into the sodium alginate-calcium carbonate composite aqueous solution until the concentration of the soybean polypeptide is 100g / L, and mix evenly to make a soybean polypeptide solution; The concentration of Brady's yeast was 1.0×10...

Embodiment 2

[0046] A synbiotic microcapsule comprises a capsule material and a wall material, the wall material includes liquid paraffin and Span80, and the capsule material contains soybean polypeptide and Brady's yeast.

[0047] Its preparation method comprises the following steps:

[0048](1) Preparation of microcapsule capsule material solution: prepare a sodium alginate solution with a concentration of 0.6g / L, and sterilize it for subsequent use; add CaCO to the obtained sodium alginate solution 3 , to CaCO 3 The concentration is up to 0.8g / L, and the sodium alginate-calcium carbonate composite aqueous solution is obtained after mixing evenly.

[0049] Add the soybean polypeptide into the sodium alginate-calcium carbonate composite aqueous solution until the concentration of the soybean polypeptide is 50g / L, and mix evenly to make a soybean polypeptide solution; The concentration of Brady's yeast was 1.5×10 6 cfu / mL, mix evenly to make a mixed phase of synbiotics;

[0050] (2) Pr...

Embodiment 3

[0054] A synbiotic microcapsule comprises a capsule material and a wall material, the wall material includes liquid paraffin and Span80, and the capsule material contains soybean polypeptide and Brady's yeast.

[0055] Its preparation method comprises the following steps:

[0056] (1) Preparation of microcapsule capsule material solution: prepare a sodium alginate solution with a concentration of 1.0 g / L, sterilize it at 115°C for 20 minutes, and store it at 4°C for later use; add CaCO to the obtained sodium alginate solution 3 , to CaCO 3 The concentration is up to 1.2g / L, and the sodium alginate-calcium carbonate composite aqueous solution is obtained after mixing evenly.

[0057] Add the soybean polypeptide into the sodium alginate-calcium carbonate composite aqueous solution until the concentration of the soybean polypeptide is 150g / L, and mix evenly to make a soybean polypeptide solution; The concentration of Brady's yeast was 2.0×10 6 cfu / mL, mix evenly to make a mixe...

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Abstract

The invention relates to synbiotic microcapsules and a preparing method and application thereof. A wall material of the synbiotic microcapsules is prepared from liquid paraffin and Span 80, and a capsule material is prepared from soybean peptide and saccharomyces boulardii. The preparing method comprises the steps that firstly, a capsule material solution and an oil phase are prepared, then the capsule material solution and the oil phase are mixed to be prepared into synbiotic microcapsules to be cultured, and finally the end products are prepared based on a fermentation culture method. The synbiotic microcapsules and the preparing method and application thereof have the advantages that according to the synbiotic microcapsules, soybean peptide and saccharomyces boulardii are wrapped into the same microcapsule, the growth promoting effect of soybean peptide on probiotics is performed, and the activity protection effect of the microcapsules on microorganisms is also performed; the end products can perform the health function of prebiotis, and the probiotic function of probiotics; the technology of carrying out wrapping before fermentation is adopted, saccharomyces boulardii obtains the opportunity for proliferation again, and thus the synbiotic microcapsules with higher density and activity can be easily obtained.

Description

technical field [0001] The invention belongs to the field of biotechnology, and in particular relates to a synbiotic microcapsule and its preparation method and application. Background technique [0002] Soybean polypeptide has excellent digestion and absorption and processing characteristics, and can promote the growth and development of microorganisms. It has been widely used in health products such as sports food, sports drinks, antihypertensive food and fatigue recovery food. [0003] Brady's Saccharomyces can reduce the secretion of pro-inflammatory factors during E. coli infection; protective effect in inflammatory bowel disease. Brady Saccharomyces can regulate the increase of the expression level of the anti-inflammatory factor IL-10, and at the same time inhibit the decrease of the pro-inflammatory cytokines TNF-α and IL-6. Therefore, it has potential preventive and therapeutic effects on enteritis. [0004] However, Saccharomyces bradymis does not form spores dur...

Claims

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Application Information

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IPC IPC(8): A61K9/50A61K47/44A61K47/26A61K38/01A61K36/48A61P1/00A61P29/00A23L33/00A23L33/14A23L33/18A23K20/147A23K10/18A61K36/064
CPCA61K9/5015A61K36/064A61K36/48A61K38/011
Inventor 魏永刚栾兆文
Owner 魏永刚
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