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Metabolism marker for diagnosis of acute coronary syndrome

A technique for metabolic markers and coronary syndrome, applied in the field of metabolic markers for the diagnosis of acute coronary syndrome, to achieve the effect of promoting standardization, high sensitivity, and improving the convenience of diagnosis

Active Publication Date: 2016-04-13
苏州帕诺米克生物科技有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] No one has used plasma metabolite levels to diagnose coronary heart disease

Method used

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  • Metabolism marker for diagnosis of acute coronary syndrome
  • Metabolism marker for diagnosis of acute coronary syndrome

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Example 1: Screening and characterization of plasma differential metabolites between patients with normal coronary arteries and patients with acute coronary syndrome

[0032] 1. Objects and methods

[0033] 1. Source of specimen

[0034] After obtaining the patient’s consent, the peripheral venous blood plasma of 460 patients with acute coronary syndrome and 350 patients with normal coronary arteries were collected from Jiangsu Provincial People’s Hospital from September 2010 to June 2015. All patients or people with normal coronary arteries were treated by coronary artery. Confirmed by angiography. The age and sex of people with normal coronary arteries match those of patients with acute coronary syndrome. All patients with acute coronary syndrome and those with normal coronary arteries have normal heart, lung, liver and kidney and hematopoietic functions.

[0035] The blood collection time was in the early morning on an empty stomach.

[0036] 2. Main reagents

[0037] Aceton...

Embodiment 2

[0058] Example 2: Construction of ROC curve to verify the ability of 7 different metabolites to diagnose acute coronary syndrome

[0059] The receiver operating curve (ROC) method was used for verification, and its ability to diagnose coronary heart disease was judged by the expression levels of differential metabolites in the plasma of patients with acute coronary syndrome and normal coronary arteries. The results showed that phosphocholine, palmitoylethanolamine, lysophosphatidylcholine (16:0), phosphatidylceramide (d18:1 / 8:0), lysophosphatidylcholine (18:2), lysophosphatidylcholine (18:2) The 7 different metabolites of choline (18:1) and phosphatidylinositol (18:3 / 0:0) are used to diagnose and distinguish acute coronary syndrome patients from patients with normal coronary arteries. The ROC curve The area under area (AUC) is greater than 0.7, which is of clinical diagnostic significance; when used in combination for diagnosis, as the number of combinations increases, the AUC fu...

Embodiment 3

[0069] Example 3: Application in screening of drugs for treatment or alleviation of acute coronary syndrome

[0070] The plasma of 190 patients with acute coronary syndrome before and after drug treatment was tested. The results showed that as the course of drug treatment increased, the patient’s condition gradually alleviated. The seven metabolic markers provided by the present invention are in plasma The level gradually tends to the level of healthy people, and there is no significant difference between the plasma levels of healthy people after complete cure (P>0.05). This result is consistent with the detection result of coronary angiography. Therefore, the metabolic markers provided by the present invention can be used to screen drugs for treating or alleviating acute coronary syndrome.

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Abstract

The invention discloses a metabolism marker for diagnosis of the acute coronary syndrome. The metabolism marker comprises one or more of phosphorylcholine, palmitoylethanolamine, lysophosphatidyl choline (16:0), phosphatidyl ceramide (d18:1 / 8:0), lysophosphatidyl choline (18:2), lysophosphatidyl choline (18:1) and phosphatidylinositol (18:3 / 0:0). When a single metabolism marker is used for diagnosis and distinguishing of acute coronary syndrome patients and coronary artery normal people, ROC area under the curve (AUC) is larger than 0.7 all the time, and clinical diagnosis significance is high; when several metabolism markers are combined to be used for diagnosis, AUC is further increased as the combination number increases and reaches the highest value 0.987 when all the seven metabolism markers are combined, and sensitivity and specificity are 99.1% and 98.9% respectively under the optimum cutoff value. The metabolism marker can be used for accurate diagnosis of the acute coronary syndrome and has high accuracy, sensitivity and specificity.

Description

Technical field [0001] The invention belongs to the field of biochemistry, relates to metabolic markers for the diagnosis and classification of coronary heart disease, and specifically relates to a set of metabolic markers for diagnosing acute coronary syndrome. Background technique [0002] Coronary heart disease, also known as ischemic heart disease, involves the occurrence of atherosclerosis in the arteries that supply blood to the myocardium, that is, coronary atherosclerotic lesions cause vascular lumen stenosis or plaque formation or even rupture and complete blockage, resulting in myocardial ischemia and hypoxia Or necrosis can lead to ischemic heart disease, leading to a series of serious cardiovascular events such as angina pectoris and myocardial infarction. Coronary heart disease is the main killer of human health. It has the characteristics of high morbidity, high disability, high recurrence rate, high fatality rate, and many complications. It has become a major disea...

Claims

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Application Information

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IPC IPC(8): G01N30/88G01N30/06
CPCG01N30/06G01N30/88
Inventor 李萍刘丽伟范勇齐炼文
Owner 苏州帕诺米克生物科技有限公司
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