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Computer system, program, and method for assisting recurrence risk diagnosis of colorectal cancer

A computer system and colorectal cancer technology, applied in computer-aided medical procedures, calculations, health index calculations, etc., can solve problems such as inability to apply to colorectal cancer

Active Publication Date: 2016-04-06
SYSMEX CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The technology disclosed in US Patent Publication 2008 / 058432 is a technique for predicting the prognosis of recurrence of specific colorectal cancer, and there is a problem that it cannot be applied to all colorectal cancers

Method used

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  • Computer system, program, and method for assisting recurrence risk diagnosis of colorectal cancer
  • Computer system, program, and method for assisting recurrence risk diagnosis of colorectal cancer
  • Computer system, program, and method for assisting recurrence risk diagnosis of colorectal cancer

Examples

Experimental program
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Embodiment approach

[0036] Preferred embodiments of the present invention will be described below with reference to the drawings.

[0037] In the diagnostic support method of colorectal cancer recurrence risk (hereinafter, sometimes referred to as "diagnostic support method") of the present embodiment, first, each of the long chains selected from the 18th chromosome in the biological sample collected from the colorectal cancer patient is measured. The first measurement of the expression levels of a plurality of genes in the first genome present in the region 18q21 to 18q23 on the upper chain, each measuring a plurality of genes selected from the second genome present in the region 20q11 to 20q13 on the long chain of chromosome 20 The second measurement of the expression level of the gene, and each measurement is selected from the third measurement including ANGPTL2, AXL, C1R, C1S, CALHM2, CTSK, DCN, EMP3, GREM1, ITGAV, KLHL5, MMP2, RAB34, SELM, SRGAP2P1 and VIM. A third measurement of the express...

Embodiment 1

[0136] [Example 1: Discussion on the classification according to the prognosis of patients with colorectal cancer]

[0137]

[0138] In Affymetrix company GeneChip, human genome U133+2.0 array data set GSE14333 (NCBI GeneExpressionOmnibus (URL; obtained from http: / / www.ncbi.nlm.nih.gov / geo / )), colorectal cancer (colon cancer) 72 cases of patients were used as the training group. As analysis software, software for array data analysis (ExpressionConsolev1.1 (manufactured by Affymetrix)), software for table calculation (OfficeExcel2002, 2007 (manufactured by Microsoft)), software for cluster analysis (Cluster3.0, Java (registered trademark) ) Treeview (obtained from: http: / / bonsai.hgc.jp / ~mdehoon / software / cluster / software.htm)) and statistical analysis software (MedCalc (manufactured by MedCalc)) for various analysis.

[0139] MAS5 was used in the normalization of the data. Among all the probes on the GeneChip, the self-analysis of probes with unknown gene symbols and probes ...

Embodiment 2

[0152] [Example 2: Reliability Verification 1 of Recurrence Risk Group Classification]

[0153]

[0154] Among the data set GSE14333 (NCBI GeneExpressionOmnibus (URL; obtained from http: / / www.ncbi.nlm.nih.gov / geo / )) of GeneChip of Affymetrix Company, human genome U133+2.0 array, will be used in the training set Patient 74 cases were used as validation group 1. It should be noted that the samples were selected according to the use of test samples obtained from medical facilities different from those of the cases of the training group and the cases of the verification group 1 .

[0155] Clustering was performed using the genes in Table 1 in the same manner as in Example 1 for 146 cases consisting of 72 cases in the training group and 74 cases in the verification group 1 .

[0156]

[0157] exist Figure 7 shows the results of the recurrence risk group classification in the cases of the training group and the validation group 1. Such as Figure 7 As can be seen, although ...

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Abstract

The invention provides a computer system used in determination of recurrence risk of colorectal cancer. The computer system is provided with a computer including a processor and a storage. The storage is recorded with a computer program which is executed in the computer. The method comprises receiving expression quantity of a plurality of genes selected by a first gene group existed in a region of 18q21 to 18q23 on an eighteenth chromosome long chain in a live sample acquired from a colorectal cancer patient, receiving expression quantity of a plurality of genes selected by a second gene group existed in a region of 20q11 to 20q13 on an twentieth chromosome long chain in a live sample acquired from a colorectal cancer patient, and receiving expression quantity of a plurality of genes selected by a third gene group including ANGPTL2, AXL, C1R, C1S, CALHM2, CTSK, DCN, EMP3, GREM1, ITGAV, KLHL5, MMP2, RAB34, SELM, SRGAP2P1, and VIM in a live sample acquired from a colorectal cancer patient, and based on the received expression quantity, determining recurrence risk of colorectal cancer for the patient.

Description

【Technical field】 [0001] The invention relates to a method for assisting in the diagnosis of the recurrence risk of colorectal cancer. In particular, it relates to a method, a program, and a computer system for obtaining expression level data of genes belonging to a specified genome from nucleic acid obtained from a tissue of a colorectal cancer patient, and assisting the diagnosis of the recurrence risk of colorectal cancer in the patient based on the obtained expression level data . 【Background technique】 [0002] Colorectal cancer is a general term for cancerous tumors that occur in the cecum, colon, and rectum. Like various cancers, early detection is also important for the treatment of colorectal cancer. In the treatment of cancer, anticancer agents with strong side effects are sometimes used, and a large burden is placed on the patient at this time. In order to reduce the burden on such patients, it is important for the doctor to select the most appropriate treatmen...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G06F19/00
CPCC12Q1/6886C12Q2600/158G01N33/57419G16H50/30Y02A90/10
Inventor 后藤健吾吉田雄一郎大友泰裕
Owner SYSMEX CORP
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