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Preparation method of oriented shish-kebab fiber

A technology of orientation and stringing, which is used in fiber processing, spinning solution preparation, pharmaceutical formulations, etc., can solve the problem of lack of cell binding sites on the surface of the scaffold, and achieve improved cell compatibility, good hydrophilicity, and accelerated precipitation. Effect

Inactive Publication Date: 2016-04-06
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, although this method simulates the structure of collagen microscopically, the worthwhile scaffold surface still lacks cell binding sites.

Method used

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  • Preparation method of oriented shish-kebab fiber
  • Preparation method of oriented shish-kebab fiber

Examples

Experimental program
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Effect test

Embodiment 1

[0035] The present embodiment is a preparation method of polycaprolactone nanofiber / chitosan-g-polycaprolactone skewered fiber, and the detailed steps of the preparation method are as follows:

[0036] (1) Dissolve PCL6500 in a mixed organic solvent of chloroform and dimethylformamide at 45° C., and make a PCL spinning solution with a mass percent concentration of 14% after dissolving; preferably, the relative molecular mass of PCL is 16 Ten thousand grams / mole; The volume ratio of chloroform and dimethylformamide is 6 to 4;

[0037] (2) Utilize the PCL spinning solution obtained in step (1) with an electrospinning device, at a temperature of 20° C., a spinning voltage of 15 kV, and a receiving distance of 15 cm. The receiving device is a stainless steel washer placed on an aluminum foil paper. Spinning and preparing PCL nanofibers;

[0038] (3) Synthesis of CS-g-PCL graft copolymer: (a) dissolving chitosan with a degree of deacetylation of 80% in methanesulfonic acid at 40°C...

Embodiment 2

[0043] (1) Dissolve PCL6500 in a mixed organic solvent of chloroform and dimethylformamide at 45° C., and make a PCL spinning solution with a mass percent concentration of 16% after dissolving; preferably, the relative molecular mass of PCL is 16% Ten thousand grams / mole; The volume ratio of chloroform and dimethylformamide is 6 to 4;

[0044] (2) Utilize the PCL spinning solution that step (1) obtains to utilize electrospinning device, at temperature be 20 ℃, and spinning voltage is 18kV, and receiving distance is 18cm, and receiving device is the stainless steel washer that is placed on the aluminum foil paper, electrospinning Spinning and preparing PCL nanofibers;

[0045] (3) Synthesis of CS-g-PCL graft copolymer: (a) dissolving chitosan with a degree of deacetylation of 80% in methanesulfonic acid at 40°C, the mass-to-volume ratio of chitosan and methanesulfonic acid 30mg / mL, and then the caprolactone monomer with chitosan molar equivalent ratio of 12 was added to the ch...

Embodiment 3

[0050] (1) Dissolve PCL6500 in a mixed organic solvent of chloroform and dimethylformamide at 60°C, and make a PCL spinning solution with a mass percent concentration of 20% after dissolving; preferably, the relative molecular mass of PCL is 16 Ten thousand grams / mole; The volume ratio of chloroform and dimethylformamide is 6 to 4;

[0051] (2) Utilize the PCL spinning solution that step (1) obtains to utilize electrospinning device, at temperature be 20 ℃, and spinning voltage is 25kV, and receiving distance is 18cm, and receiving device is the stainless steel washer that is placed on the aluminum foil paper, electrospinning Spinning and preparing PCL nanofibers;

[0052] (3) Synthesis of CS-g-PCL graft copolymer: (a) dissolving chitosan with a degree of deacetylation of 80% in methanesulfonic acid at 40°C, the mass-to-volume ratio of chitosan and methanesulfonic acid 40mg / mL, and then the caprolactone monomer with a chitosan molar equivalent ratio of 6 was added to the chit...

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Abstract

The invention relates to a preparation method of an oriented shish-kebab fiber and belongs to the technical field of biomedical tissue engineering. The preparation method includes the following steps that oriented nanofibers are obtained through an electrostatic spinning method, grafted copolymer is obtained through a graft copolymerization method, and finally the oriented shish-kebab fiber is obtained through the method that the nanofibers obtained through an electrostatic spinning method induce the grafted copolymer to conduct crystallization. Through the special structure, performance of different polymers can be combined to improve the hydrophilia and the cytocompatibility of electrostatic spinning fibers, and the purpose of stimulating a bone tissue structure on the microscopic scale can be achieved.

Description

technical field [0001] The invention belongs to the technical field of biomedical tissue engineering, and in particular relates to a method for preparing oriented skewered fibers. Background technique [0002] The common clinical problems in orthopedics are bone defect and fracture nonunion. Tissue engineering provides a new idea for the bone source required for bone defect repair. Polylactic acid and polycaprolactone have good biocompatibility and degradability, and are biomedical materials that have been approved by the US Food and Drug Administration (FDA) for human use. Polycaprolactone and polylactic acid have good mechanical properties and a degradation rate that matches bone tissue regeneration, and have broad application prospects in bone repair and cartilage repair [Rajzer I. Journal of Materials Science, 2014, 49: 5799-5807]. However, as synthetic polymers, such polymers lack cell binding sites, which greatly limits their application in the field of tissue enginee...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): D06M15/507D06M15/03D01F6/62D01F11/08D01D1/02D01D5/00A61L27/18A61L27/34A61L27/50D06M101/32
CPCD06M15/507A61L27/18A61L27/34A61L27/50A61L2400/18A61L2430/02D01D1/02D01D5/0007D01F6/625D01F11/08D06M15/03D06M2101/32
Inventor 经鑫彭响方米皓阳童立生
Owner SOUTH CHINA UNIV OF TECH
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