Platinum complex with aggregation-caused red light emitting function as well as preparation method and application of platinum complex
A platinum complex, aggregation-induced technology, applied in platinum group organic compounds, platinum group organic compounds, preparations for in vivo tests, etc., can solve the problems of large cytotoxicity, poor photostability, and large background fluorescence interference, etc. Achieve the effect of improving signal-to-noise ratio and sensitivity, mild conditions, and simple synthesis steps
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Embodiment 1
[0031] Embodiment 1, the preparation of platinum complex, when R is Ligand is Time:
[0032] Preparation of compound 1a:
[0033]
[0034] Take o-hydroxybenzaldehyde (2.3mL, 22mmol) and dissolve it in 20mL ethanol, then weigh pentafluoroaniline (4.0g, 22mmol) and dissolve it in 20mL ethanol, then add it dropwise to the ethanol solution of o-hydroxybenzaldehyde, add 1 Acetic acid was dropped as a catalyst, stirred and reacted at room temperature for 2 hours. After the reaction, the mixture was concentrated and separated by column chromatography using petroleum ether / dichloromethane as eluent to obtain 5.4 g of a yellow solid with a yield of 85%. 1 HNMR (400MHz, CDCl 3 )δ8.83(s,1H),7.49-7.40(m,2H),7.07-6.97(m,2H).
[0035]
[0036] Phenylpyridine Platinum Dichloro Bridge ((ppy)Pt(μ-Cl) 2 Pt(ppy)) preparation: Weigh potassium chloroplatinite (1mmol) and 2-phenylpyridine (2.5mmol) into a three-necked flask, vacuumize on the double-row tube-fill with nitrogen-vacuumize...
Embodiment 2
[0040] Example 2: Compound Characterization
[0041] Compound (5-10mg) is dissolved in the deuterated reagent of 0.5ml, utilizes 400Hz nuclear magnetometer to characterize the structure of part compound respectively, wherein the nuclear magnetic resonance spectrum of complex 1 in embodiment 1 is as attached figure 1 shown.
Embodiment 3
[0042] Embodiment 3: The ultraviolet-visible absorption spectrum test of complex in tetrahydrofuran solution
[0043] Configure the tetrahydrofuran solution of 10 μmol / L complex, and test its ultraviolet-visible absorption spectrum on the ultraviolet spectrophotometer, the absorption spectrum result of complex 1 is as follows figure 2 shown.
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