Application of nitrogen mustard based piperlongumine compound in medicine
A technology of piperonamides and compounds is applied to the application field of nitrogen mustardyl piperonamide compounds in medicine, and can solve problems such as the application of nitrogen mustardyl piperonamide compounds which have not been seen before.
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Embodiment 1
[0017] Example 1: Compound DJBB-1 preparation of
[0018] The synthetic route is as follows:
[0019]
[0020] For the synthetic route of intermediate 1, please refer to the reference (Liu Wenhu et al., Acta Pharmaceutica Sinica, 2014, 49(2):217-224).
[0021] For the synthetic route of intermediate 2, please refer to the reference (Shoujiao Pengetal, J. Med. Chem. 2015, 58, 5242? 5255).
[0022] The synthetic route of compound DJBB-1 can be found in the reference (ShoujiaoPengetal, J.Med.Chem.2015, 58, 5242? 5255):
[0023] Add raw material 110mmol, intermediate 210mmol, CH 2 Cl 2 10ml, 10ml of triethylamine, stirred at room temperature for 10h. Then add saturated NH 4 Washed with Cl solution, CH 2 Cl 2 Extraction, washing with saturated brine, MgSO 4 Dried and concentrated. The crude product was separated by column chromatography with a yield of 65%.
[0024] 1 HNMR (400MHz, CDCl 3 ): δ7.89(d,J=15.6Hz,1H),7.60-7.54(m,2H),7.34(d,J=15.6Hz,1H),6.94-6.90(m,3H),6...
Embodiment 2
[0026] Embodiment 2: compound DJBB-2 preparation of
[0027] The synthetic route is the same as compound DJBB-1.
[0028] The yield of compound DJBB-2 was 60%.
[0029] 1 HNMR (400MHz, CDCl 3 ): δ7.90(d,J=15.6Hz,1H),7.32(d,J=15.6Hz,1H),6.96-6.92(m,3H),6.02(t,J=9.6Hz,1H),4.06 (t, J=6.4Hz, 2H), 3.89(s, 6H), 3.86(t, J=7.6Hz, 4H), 3.74(t, J=7.6Hz, 4H), 2.42(m, 2H).
[0030] MS-ESI (m / z): 449.10 (M+Na 十 ).
Embodiment 3
[0031] Embodiment 3: compound DJBB-3 preparation of
[0032] The synthetic route is the same as compound DJBB-1.
[0033] The yield of compound DJBB-3 was 56%.
[0034] 1 HNMR (400MHz, CDCl 3 ): δ7.92(d,J=15.6Hz,1H),7.36(d,J=15.6Hz,1H),6.96-6.92(m,3H),6.03(t,J=9.6Hz,1H),4.03 (t, J = 6.4Hz, 2H), 3.82 (t, J = 7.6Hz, 4H), 3.76 (t, J = 7.6Hz, 4H), 2.46 (m, 2H).
[0035] MS-ESI (m / z): 425.06 (M+Na 十 ).
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