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Perhexiline capsule and preparation method thereof

A technology for coronary heart disease and angina pectoris, applied in the field of Xinshuning capsules and its preparation, can solve the problems of slow disintegration, unsatisfactory curative effect, and low curative effect

Inactive Publication Date: 2016-03-23
HEILONGJIANG JIANGHENG PHARMA TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The curative effect of Xinshuning Capsules on the market is not ideal due to the composition and process. The preparation is prepared by traditional technology, which has the disadvantages of slow disintegration and low curative effect.

Method used

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  • Perhexiline capsule and preparation method thereof
  • Perhexiline capsule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Take 155g of nutmeg, 77.5g of perrin, 1080g of holly holly, 540g of ginkgo biloba, 330g of motherwort, 330g of weltweed, grind them into 60-mesh coarse powder, and extract them with carbon dioxide supercritical extraction method. The extraction pressure is 23Mpa and the extraction temperature is 16°C. The pressure of the separator is 12Mpa, the temperature of the separator is 38°C, the separation time is 1.9 hours, and the flow rate of carbon dioxide is 24L per hour to obtain the extract; take the extract and dry it under reduced pressure at 61°C to obtain a dry paste; add 150g of mannitol to the dry paste, and use high-energy nano impact Grind and pulverize into a mixed dry paste powder with a particle size of 200-300nm; take the mixed dry paste powder, 45g of microcrystalline cellulose, 45g of cross-linked polyvinylpyrrolidone, and 35g of cross-linked sodium carboxymethylcellulose, mix well, and wash with 50% ethanol Wet granulation, drying at 60°C, adding 7 g of sodiu...

specific Embodiment 2

[0026] Take 155g of nutmeg, 77.5g of perrin, 1080g of holly, 540g of ginkgo biloba, 330g of motherwort, and 330g of weltweed, grind them into 60-mesh coarse powder, and extract them with carbon dioxide supercritical extraction method. The extraction pressure is 38Mpa, and the extraction temperature is 39°C. The pressure of the separator is 19Mpa, the temperature of the separator is 59°C, the separation time is 3.4 hours, the flow rate of carbon dioxide is 35L per hour, and the extract is obtained; the extract is dried under reduced pressure at 79°C to obtain a dry paste; the dry paste is added with 200g of mannitol, and the high-energy nano impact Grind and pulverize into a mixed dry paste powder with a particle size of 200-300nm; take the mixed dry paste powder, 55g of microcrystalline cellulose, 55g of cross-linked polyvinylpyrrolidone, and 45g of cross-linked sodium carboxymethylcellulose, mix well, and wash with 70% ethanol Wet granulation, drying at 80°C, adding 9 g of sod...

Embodiment 3

[0028] Take 155g of nutmeg, 77.5g of peylan, 1080g of holly, 540g of ginkgo biloba, 330g of motherwort, 330g of weltweed, grind them into 60-mesh coarse powder, and extract them by carbon dioxide supercritical extraction method. The extraction pressure is 31Mpa and the extraction temperature is 28°C. The pressure of the separator is 15Mpa, the temperature of the separator is 48°C, the separation time is 2.7 hours, and the flow rate of carbon dioxide is 30L per hour to obtain the extract; take the extract and dry it under reduced pressure at 70°C to obtain a dry cream; add 175g of mannitol to the dry cream, and use high-energy nano impact Grind and pulverize into a mixed dry cream powder with a particle size of 200-300nm; take the mixed dry cream powder, 50g of microcrystalline cellulose, 50g of cross-linked polyvinylpyrrolidone, and 40g of cross-linked sodium carboxymethylcellulose, mix well, and wash with 60% ethanol Wet granulation, drying at 70°C, adding 8 g of sodium carbox...

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Abstract

The invention discloses a perhexiline capsule and a preparation method thereof. The perhexiline capsule is characterized in that 155 g of nutmeg, 77.5 g of eupatorium, 1080 g of pubescent holly roots, 540 g of ginkgo leaves, 330 g of motherwort and 330 g of herba siegesbeckiae are taken, a carbon dioxide supercritical extraction method is adopted for extraction, drying is performed under reduced pressure, the materials are smashed into nano dry paste through a high-energy nano impacting mill, functional auxiliaries are added, the perhexiline capsule is prepared, the disintegrating time is remarkably shortened, the curative effect is remarkably superior to that of perhexiline capsules sold on the market, and a positive effect is achieved.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicines, in particular to Xinshuning capsules and a preparation method thereof. Background technique [0002] Xinshuning Capsule promotes blood circulation and removes blood stasis. It is used for chest pain, coronary heart disease, angina pectoris, coronary insufficiency, and arteriosclerosis caused by the above symptoms. The curative effect of Xinshuning Capsules on the market is not ideal due to the composition and process, and the preparation is prepared by traditional technology, which has the disadvantages of slow disintegration and low curative effect. Contents of the invention [0003] In order to overcome the above disadvantages, the present invention provides Xinshuning capsules with fast disintegration speed and high curative effect and a preparation method thereof. [0004] Invention embodiment is as follows: [0005] Take 155g of nutmeg, 77.5g of peylan, 1080g of holly, 540g o...

Claims

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Application Information

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IPC IPC(8): A61K36/533A61K9/48A61P29/00A61P9/10A61P9/00
CPCA61K36/185A61K9/1652A61K36/16A61K36/28A61K36/533A61K2236/37
Inventor 不公告发明人
Owner HEILONGJIANG JIANGHENG PHARMA TECH CO LTD
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