Multi-parameter detection method and device for biological tissue blood flow, blood oxygen and blood volume

Abstract

The invention discloses a multi-parameter detection method and device for biological tissue blood flow, blood oxygen and blood volume. In this method, two laser beams of different wavelengths are used to irradiate biological tissues simultaneously, and the photoelectric imaging system continuously collects several frames of color images of biological tissues illuminated by the laser beams. Take out the light intensity values ​​of the red channel and the green channel on each pixel of the image to form a red channel image and a green channel image respectively. Apply the laser speckle blood flow imaging data analysis method and the dual-wavelength spectral data analysis method to process the above red channel image and green channel image, and obtain the two-dimensional data of multiple physiological parameters of blood flow, oxygenated hemoglobin concentration, and reduced hemoglobin concentration in the corresponding biological tissue. Spatial distribution and its dynamic change information. The present invention solves the disadvantage that the multi-parameter blood flow imaging system based on multi-wavelength time-sharing imaging is difficult to achieve accurate time synchronization, and also avoids the disadvantage that the multi-parameter blood flow imaging system based on multi-camera shooting needs to use multiple cameras to increase the cost.

Description

technical field [0001] The patent of the present invention belongs to the field of biomedical imaging, and specifically relates to an easy-to-use and low-cost multi-parameter detection method and device, which can realize real-time imaging of multiple hemodynamic information of biological tissues such as human skin and cerebral cortex, and Continuous monitoring. Background technique [0002] The multi-parameter monitoring of biological tissue hemodynamics is very important for studying the physiological state of living organisms. The general multi-parameter blood flow imaging system is realized by combining basic optical imaging methods such as various fluorescence imaging, endogenous signal optical imaging and laser speckle blood flow imaging, and these optical imaging are achieved by using incoherent or coherent The light source irradiates biological tissue, collects its reflected light, and analyzes the reflected light information to obtain hemodynamic parameters. Howev...

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Problems solved by technology

[0006] This system uses a beam splitter and an optical filter to split the reflected light carrying the signal according to different wavelengths, and then collects it with multiple monochrome cameras. This method can avoid time-sharing acquisition of multi-wavelength signals. However, this method requires the design of special optical and mechanical structures to ensure accurate registration between images obtained by different cameras, and the cost is relatively high.

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