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Two optically pure isomers of NK007 and bactericidal applications

A technology of optical isomers, isomers, used in applications, fungicides, chemicals for biological control, etc., to achieve the effect of good bactericidal activity

Active Publication Date: 2016-03-16
NANKAI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, NK007 is a racemate with four optical isomers, and these four optical isomers of NK007 have not been reported as new compounds regarding their bactericidal activity

Method used

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  • Two optically pure isomers of NK007 and bactericidal applications
  • Two optically pure isomers of NK007 and bactericidal applications
  • Two optically pure isomers of NK007 and bactericidal applications

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] The physicochemical data (table 1) of embodiment 1 compound NK007-3 and NK007-4

[0019] Table 1

[0020]

[0021]

Embodiment 2

[0022] The bactericidal activity (table 2) of embodiment 2 compound NK007-3 and NK007-4

[0023] The measurement procedure is as follows:

[0024] Determination of bacterial growth rate (plate method): Dissolve a certain amount of medicine in an appropriate amount of acetone, then dilute it to the required concentration with an aqueous solution containing 200 μg / mL emulsifier, then draw 1mL of the medicine solution into the petri dish, and then add Shake 9mL of medium to make a 50μg / mL drug-containing plate, and add 1mL of sterilized water as a blank control. Use a puncher with a diameter of 4mm to cut out the bacterial plate along the outer edge of the hyphae, and move it to the drug-containing plate. Each treatment was repeated three times. Place the culture dish in a constant temperature incubator at 24±1°C. After 48 hours, investigate the expanded diameters of the bacteria discs of each treatment, calculate the average value, and compare with the blank control to calcul...

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Abstract

The invention relates to two optically pure isomers of NK007 for short and applications in a bactericidal aspect. Compounds NK007-3 and NK007-4 have good bactericidal activity, can be used for treating plant bacteria diseases selected from fusarium wilt of cucumber, cercospora brown spot of peanut, apple ring spot, alternaria solani, puccinia polysora, rice bakanae disease, sclerotinia rot of colza, phytophthora capsici disease, wheat sharp eyespot, bipolaris maydis, watermelon anthracnose, potato late blight, rice sheath blight disease and cucumber gray mold.

Description

technical field [0001] The present invention relates to two optically pure isomers called NK007 for short and their application in the field of sterilization. Background technique [0002] The structural formula of the compound referred to as NK007 is: [0003] [0004] Chirality is a basic feature of life processes, macromolecules as an important basis for life activities. Such as nucleic acids, proteins, polysaccharides, etc. all have chirality: when a chiral drug enters a living body, its two enantiomers usually exhibit different biological activities. Due to the lack of awareness of this, human beings have learned a painful lesson before. For example, a drug developed by a German pharmaceutical company in the 1950s to treat the early discomfort of pregnant women—the drug was very effective, but it was soon discovered that many babies born to pregnant women who took the drug had mutilated limbs. Later, it was found that one configuration of thalidomide has a teratog...

Claims

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Application Information

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IPC IPC(8): A01N43/90C07D471/04A01P3/00
CPCA01N43/90C07B2200/07C07D471/04
Inventor 汪清民尹芝南王兹稳洪章勇刘玉秀温倜宋红健郑彦龙
Owner NANKAI UNIV
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