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A cyclosporine composition for treating hemolytic anemia and its application

A hemolytic anemia and cyclosporine technology, applied in the field of medicine, can solve the problems of long-term tolerance of patients, strong adverse reactions, etc., achieve low side effects and adverse reaction rates, increase safety and compliance, side effects and adverse reactions Response rate reduction effect

Active Publication Date: 2018-04-24
THE FIRST AFFILIATED HOSPITAL OF XINXIANG MEDICAL UNIV
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Problems solved by technology

However, the treatment of such diseases often requires patients to take medicine for a long time, and the existing immunosuppressants generally have the disadvantages of strong adverse reactions and difficult long-term tolerance for patients

Method used

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  • A cyclosporine composition for treating hemolytic anemia and its application

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Effect test

Embodiment 1

[0015] Example 1 Efficacy test of montelukast sodium combined with cyclosporine on hemolytic anemia model rats

[0016] 50 Wistar rats, weighing 180-220 g. Breeding conditions: room temperature at 20-25°C, relative humidity at 38%-41%, artificial lighting, light and dark for 12 hours, solid common feed and tap water, free intake of food and water, good ventilation; clean indoor sanitation twice a day, keep indoor No obvious ammonia odor.

[0017] 50 rats were randomly divided into the following five groups: normal control group, model control group, MK group, CSA group, MK-CSA group, 10 rats in each group, half male and half male. After the rats were fed adaptively for one week, except the normal control group, the other groups were intraperitoneally injected with 2% acetylphenylhydrazine normal saline solution 0.2g / kg on the first day and the fourth day respectively, and the normal control group was injected with normal saline instead. On the same day after successful model...

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Abstract

The invention discloses a pharmaceutical composition for treating hemolytic anemia and its application. The active ingredients in the pharmaceutical composition are composed of montelukast sodium and cyclosporine, and the two have different action targets in the treatment of hemolytic anemia. At the same time, the side effects and adverse reaction rate of montelukast sodium are low, and the dosage of cyclosporine is only one-fifth of the conventional dosage, so the cost of medication, side effects and adverse reaction rate are also greatly reduced. Increased patient medication safety and compliance.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a cyclosporine composition for treating hemolytic anemia and its application. Background technique [0002] Hemolytic anemia (hemolyticanemia, HA) refers to a type of anemia that occurs when red blood cell destruction is accelerated and bone marrow hematopoietic function is insufficient to compensate. Hemolysis is the process of destroying red blood cells and shortening their lifespan. The bone marrow has 6-8 times the compensatory ability of normal hematopoiesis. When the hemolysis exceeds the compensatory ability of the bone marrow, the anemia caused is hemolytic anemia; when hemolysis occurs and the bone marrow can compensate, there is no anemia, which is called hemolytic state ( hemolytic state). The root cause of hemolytic anemia is the shortened lifespan of red blood cells, and the reasons for the accelerated destruction of red blood cells can be summarized i...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/13A61K31/47A61P7/00A61P7/06
CPCA61K31/47A61K38/13A61K2300/00
Inventor 李敬东杨翠马栋黄琰李昂
Owner THE FIRST AFFILIATED HOSPITAL OF XINXIANG MEDICAL UNIV
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