Micro-fluidic chip used for reconstructing bone cell microenvironment and use method thereof
A microfluidic chip and bone cell technology, applied in the direction of supporting/immobilizing microorganisms, bone/connective tissue cells, tissue cells/virus culture devices, etc., can solve the problem that it is difficult to truly reflect the biological characteristics of bone cells in the physiological state, etc. question
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[0028] Before introducing the present invention, the principle of chip design is explained first. Please refer to figure 1 , there is a thiol molecule (EG-terminatedthiols, referred to as EG6) whose functional group is polyethanol long chain (PEG), the molecular formula is (HS(CH 2 ) 11 (OCH 2 CH 2 ) 6 OH). This thiol molecule can react with metallic gold (Au) to form a gold-sulfur bond on one side of the sulfur atom (S). The other end of the thiol can resist protein adsorption because of the presence of PEG, thereby preventing cells from adsorbing on the Au surface.
[0029] The present invention combines microfluidic chip technology with bone cell culture technology, and uses calcium alginate polymer to cover the bone cell body and expose the cell synapse by limiting the directional growth of cell synapses along nanometer-sized channels. Finally, fluid oscillating flow stimulation was introduced to better simulate the microenvironment of bone cells under physiological...
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