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Method for carrying out superfine wall breaking and smashing on boletus

A technology of ultra-fine wall-breaking pulverization and boletus, applied in the field of medicine, can solve the problems of low powder yield, high loss rate of adenosine, long pulverization time, etc., and achieves high powder yield, small average particle size of powder, The effect of short processing times

Inactive Publication Date: 2016-02-17
SUZHOU PULUODA BIOLOGICAL SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing method of ultrafine wall-broken crushing of Boletus cerevisiae has problems such as long crushing time, low powder extraction rate and high loss rate of adenosine

Method used

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  • Method for carrying out superfine wall breaking and smashing on boletus
  • Method for carrying out superfine wall breaking and smashing on boletus
  • Method for carrying out superfine wall breaking and smashing on boletus

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Crush 3kg of yellow boletus and pass through a 60-80 mesh sieve to obtain yellow boletus powder; mix 8g of γ-cyclodextrin and 2g of medium-chain triglyceride evenly to obtain γ-cyclodextrin-medium-chain triglyceride mixed powder ;Mix boletus powder and γ-cyclodextrin-medium chain triglyceride mixed powder evenly, and use SWFJ ultrafine pulverizer to pulverize for 1 hour, and measure the average particle size, powder extraction rate, adenosine retention rate and dissolution of the obtained powder The results are shown in Table 1.

[0017] The relevant data of the boletus superfine powder of table 1 embodiment 1

[0018]

Embodiment 2

[0020] Crush 3kg of yellow boletus and pass through a 60-80 mesh sieve to obtain yellow boletus powder; mix 12g of γ-cyclodextrin and 3g of medium-chain triglycerides evenly to obtain γ-cyclodextrin-medium-chain triglycerides mixed powder ;Mix boletus powder and γ-cyclodextrin-medium chain triglyceride mixed powder evenly, and use SWFJ ultrafine pulverizer to pulverize for 1 hour, and measure the average particle size, powder extraction rate, adenosine retention rate and dissolution of the obtained powder The results are shown in Table 2.

[0021] The relevant data of the boletus superfine powder of table 2 embodiment 2

[0022]

Embodiment 3

[0024] Grind 3kg of yellow boletus and pass through a 60-80 mesh sieve to obtain yellow boletus powder; mix 9.6g of γ-cyclodextrin and 2.4g of medium-chain triglycerides evenly to obtain γ-cyclodextrin-medium-chain triglycerides Mixed powder: Mix boletus powder and γ-cyclodextrin-medium chain triglyceride mixed powder evenly, and use SWFJ ultrafine pulverizer to pulverize for 1 hour, and measure the average particle size, powder yield, and adenosine retention rate of the obtained powder And dissolution rate, the results are shown in Table 3.

[0025] The relevant data of the boletus superfine powder of table 3 embodiment 3

[0026]

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Abstract

The invention provides a method for carrying out superfine wall breaking and smashing on boletus, and belongs to the field of traditional Chinese medicine. The method for carrying out the superfine wall breaking and smashing on the boletus is characterized by comprising the following steps of (1) smashing the boletus, sieving by a 60 to 80-mesh sieve, and obtaining the boletus powder; (2) uniformly mixing gamma-cyclodextrins with medium chain triglyceride, and obtaining gamma-cyclodextrins-medium chain triglyceride mixed powder, wherein a mass ratio of the gamma-cyclodextrins to the medium chain triglyceride is preferably 8:2; (3) uniformly mixing the boletus powder with the gamma-cyclodextrins-medium chain triglyceride mixed powder, wherein the mass ratio of the boletus powder to the gamma-cyclodextrins-medium chain triglyceride mixed powder is (200-300):1. Compared with a conventional superfine wall breaking and smashing method, the method for carrying out the superfine wall breaking and smashing on the boletus, disclosed by the invention, has the advantages that the processing time is short, the powder extraction rate is high, the retention rate and the dissolution rate of adenosine are high, the average particle diameter of powder is small, and the like.

Description

technical field [0001] The invention relates to a method for ultrafine wall-breaking and pulverizing of boletus chrysalis, which belongs to the technical field of medicine. Background technique [0002] Yellow boletus, a type of fungus, is now widely eaten. It has medicinal effects such as clearing heat and relieving troubles, nourishing blood and neutralizing, and aiding digestion. It is often used in powder form. [0003] After the superfine pulverization of the boletus, due to the increase of the specific surface area of ​​the particle size, the dissolution rate of active ingredients such as adenosine can be greatly increased, thereby improving the efficacy of the drug. The existing ultrafine wall-broken crushing method of Boletus cerevisiae has problems such as long crushing time, low powder yield and high loss rate of adenosine. Contents of the invention [0004] The purpose of the present invention is to provide a method for ultrafine wall-breaking and pulverizing o...

Claims

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Application Information

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IPC IPC(8): A61K36/06A61K47/40A61K47/14
Inventor 罗瑞雪张振海
Owner SUZHOU PULUODA BIOLOGICAL SCI & TECH
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