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A preparation method of animal anti-anemia microcapsule and its application in animal nutrition

A technology for animals and nutritional agents, applied in microcapsules, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve problems affecting the economic benefits of animal breeding, lack of iron and cobalt trace elements, animal poisoning environment, etc., to achieve element types reduction, production process simplification, and obvious anti-anemia effect

Active Publication Date: 2018-03-13
SICHUAN AGRI UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, most animals are kept in captivity, and unreasonable dietary formulas are prone to cause animal anemia due to lack of iron and cobalt trace elements, which seriously affects the economic benefits of animal breeding
Trace element feed additives are likely to cause uneven mixing and cause animal poisoning and environmental pollution

Method used

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  • A preparation method of animal anti-anemia microcapsule and its application in animal nutrition
  • A preparation method of animal anti-anemia microcapsule and its application in animal nutrition
  • A preparation method of animal anti-anemia microcapsule and its application in animal nutrition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] A. Method

[0027] 1. Use the low-iron feed formula recommended by the Association of Analytical Chemistry Workers (AOAC) to formulate animal feed: 54% corn starch, 40% milk powder, 5% soybean oil, and 1% salt. Select mice weighing (40±5) g, half male and half male, fed with low-iron feed, and blood samples are collected weekly to detect changes in blood cells. When the blood physiological related indexes are lower than the reference value, it means that the anemia model is successfully constructed (Table 1). The anemia model mice were divided into control group and test group. The experimental group was fed iron-cobalt composite microcapsules at a dose of 0.1 g / kg, and gavage every other day.

[0028] 2. Compare the blood physiological indicators and body weight changes before and 45 days after the microcapsules are administered.

[0029] B. Results

[0030] 1. The blood physiological indicators of mice fed low-iron feed for a period of time are shown in Table 1. The model ...

Embodiment 2

[0043] A. Method

[0044] 1. Use the low-iron feed formula recommended by the Association of Analytical Chemistry Workers (AOAC) to formulate animal feed: 54% corn starch, 40% milk powder, 5% soybean oil, and 1% salt. Select mice weighing (40±5) g, half male and half male, fed with low-iron feed, and blood samples are collected weekly to detect changes in blood cells. When the blood physiological related indexes are lower than the reference value, it means that the anemia model is successfully constructed (Table 1). The anemia model mice were divided into control group and test group. The experimental group was fed iron-cobalt composite microcapsules at a dose of 0.2 g / kg, and gavage every other day.

[0045] 2. Compare the blood physiological indicators and body weight changes before and 45 days after the microcapsules are administered.

[0046] B. Results

[0047] 1. The blood physiological indicators of mice fed low-iron feed for a period of time are shown in Table 5. The model ...

Embodiment 3

[0060] A. Method

[0061] Twenty anemia mice were divided into a test group and a control group, each with 10 mice. The test group was administrated with iron-cobalt composite microcapsules 0.15g / kg body weight, and the control group was administrated with physiological saline 0.15ml / kg body weight. Observe the condition of anemic mice 15 days after administration.

[0062] B. Results

[0063]

[0064] C. Summary

[0065] Anemia mice fed with iron-cobalt composite microcapsules have increased appetite, significantly better mental status than the control group, and brighter coats, indicating that the preparation can enhance the immunity of mice, promote metabolism, and improve animal health.

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Abstract

The invention discloses a preparation method and animal nutrition application of animal anti-anemia micro-capsules. The anti-anemia micro-capsules which take ferric citrate as the main ingredient, take cobalt chloride as capsule cores and take acrylic resin as capsule materials are prepared from tiny capsules which are prepared through the step that ferric citrate powder and cobalt chloride are taken as the main active ingredients to be fully heated, stirred and dissolved in oil-water solvent. The animal anti-anemia micro-capsules overcome the defect that animal poisoning and environmental polluting are prone to be caused due to uneven material stirring and mixing of a conventional feed additive, are balanced in feeding, safe, effective, convenient to use, free of toxic and side effects and capable of simultaneously and slowly releasing and supplementing iron-cobalt trace elements and have the effects of promoting growth and resisting anemia and the important significance on development of the breeding industry.

Description

Technical field [0001] The invention belongs to the technical field of veterinary medicines, and relates to a preparation method for promoting clinical animal anti-anemia microcapsules, in particular to a preparation method of animal anti-anemia drug microcapsules. Background technique [0002] Trace elements are an important material basis for animal organisms to survive and grow healthily. Among them, the main functions of cobalt and iron in the body are: cobalt plays a physiological role in the form of vitamin B12 and coenzyme B12, and the main role of vitamin B12 is to stimulate hematopoietic function. Iron and protein form heme, which is the main component of red blood cells. Iron is also involved in catalyzing the production of antibodies, improving the activity of various bactericidal enzymes and phagocytes, and improving immunity. [0003] At present, most animals are kept in captivity, and irrational diet formulas are prone to lead to lack of iron and cobalt trace elemen...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K33/24A61K9/50A61P7/06A61P37/04A61K31/295
CPCA61K9/5026A61K33/24A61K33/26A61K2300/00
Inventor 胡延春汤承岳华乔艳许锐光吴冬梅蔡海王远微
Owner SICHUAN AGRI UNIV
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