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Method and system for assessing health status

A biomarker and target technology, applied in the field of computer-readable media for assessing whether a subject mammal has a target disease, and a computer-aided system for assessing whether a test mammal has a target disease, can solve the problem of difficult comparison of results and insufficient data Points and other issues, to achieve sensitive measurement, reproducible measurement effect

Active Publication Date: 2018-08-03
PROCTER & GAMBLE CO
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

Therefore, the results between different patients and different examiners are difficult to compare
Furthermore, despite the complexity of the oral microbiome and the suspected polymicrobial nature of chronic oral infections, population-wide investigations of the microbiota associated with gingivitis have been limited to only a few culturable bacteria (e.g. "red complex" including gingival Porphyromonas gingivalis, Tannerella forsythia, and Treponemadenticola), which provide insufficient data points for a complete analysis of the different microorganisms that can potentially cause gingivitis

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  • Method and system for assessing health status
  • Method and system for assessing health status
  • Method and system for assessing health status

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[0113] The examples herein are intended to illustrate the invention but are not intended to limit or otherwise limit the scope of the invention.

[0114] acronym list :

[0115] NG: Naturally occurring gingivitis

[0116] EG: Experimental gingivitis

[0117] MGI: Modified / Mazza Gingival Index

[0118] BOP: bleeding on probing

[0119] MiGs: Microbial Gingivitis Index

[0120] RPM: Regression-Progression Model

[0121] PAM: segmentation algorithm around center point (clustering algorithm)

[0122] PCA: Principal Component Analysis

[0123] PCoA: Principal Coordinates Analysis

[0124] FDR: false discovery rate

[0125] COG: Clustering of Ortholog Groups

[0126] MiG: Microbial Gingivitis Index

[0127] MiG-S: Microbial Gingivitis Susceptibility Index

[0128] ROC: Receptor Action Characteristic

[0129] CI: confidence interval

[0130] KO: KEGG ortholog

[0131] Target Conditions and Biomarkers

[0132] The regression-progression model (RPM) was designed to s...

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Abstract

The present invention provides a method of assessing whether a subject mammal has a condition of interest, the method comprising using the abundance of a first set of biomarkers and the abundance of a second set of biomarkers for assessing whether said subject mammal has said condition of interest Functional formulation of abundance. Also provided are computer-aided systems for assessing whether a subject mammal has a condition of interest and computer readable media for assessing whether a mammal has a condition of interest.

Description

technical field [0001] The present invention relates to methods of assessing whether a subject mammal has a condition of interest. The present invention also relates to a computer-aided system for assessing whether a subject mammal has a condition of interest. The invention also relates to computer readable media for assessing whether a subject mammal has a condition of interest. Background technique [0002] The health status of the subject is usually assessed based on a variety of symptoms. However, many symptoms used for health assessment today are misleading due to their subjective description and uncertain relationship to disease state. [0003] Often, an undesired condition begins as an asymptomatic disease that, if left untreated, progresses to a more serious condition. Detecting such diseases at an early stage can be difficult. Although doctors or other medical professionals are trained in disease detection, proper testing is time-consuming. Furthermore, quantif...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12Q1/02C12Q1/689G01N33/68G06F19/18G06F19/24G16B40/00G16B20/00G16B20/20
CPCC12Q1/02G01N33/68G01N2800/60C12Q1/689G16B20/00G16B40/00G16B20/20
Inventor 李睿黄适T·何刘吉泉徐健
Owner PROCTER & GAMBLE CO
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