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Application of Shanhaidan chrysanthemum indicum injection in aerosol inhalation, spray bottle aerial fog and rectal administration and method

A technology of wild chrysanthemum injection and atomization inhalation, which can be used in pharmaceutical formulations, aerosol delivery, medical preparations containing active ingredients, etc.

Inactive Publication Date: 2016-02-10
陕西医药控股集团山海丹药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, Yejuhua Injection is administered in the form of intramuscular injection in clinical practice, and there are treatment risks such as pain at the injection site, infection, broken needle, etc., and reduces the patient's treatment compliance

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] In the embodiment of the present invention, Shanhaidan wild chrysanthemum injection is used to prepare atomized inhalation preparations: 0.2% osmotic pressure regulator is added to the wild chrysanthemum injection, and the pH value is adjusted to 6.3 with a pH regulator, and the resulting solution is atomized by ultrasonic or compression Machine made into nebulized inhalation preparations, which are directly inhaled into the respiratory system in the form of nebulization.

Embodiment 2

[0015] In the embodiment of the present invention, the Shanhaidan wild chrysanthemum injection was used to prepare a spray bottle aerosol preparation: 0.3% of an osmotic pressure regulator was added to the wild chrysanthemum injection, and the pH value was adjusted to 6.8 with a pH regulator, and the resulting solution was put into a spray bottle to prepare An aerosol formulation in a spray bottle to cover the respiratory system by means of a topical spray.

Embodiment 3

[0017] In the embodiment of the present invention, the Shanhaidan wild chrysanthemum injection was used to prepare a rectal administration preparation: 0.25% of a rectal absorption promoter was added to the wild chrysanthemum injection, and the pH value was adjusted to 6.5 with a pH regulator, and the resulting solution was made into a rectal administration preparation. Enter the blood circulation through the rectal vein.

[0018] The range of clinical nebulization inhalation of Wild Chrysanthemum Injection in the treatment of respiratory system infectious diseases involves: herpetic angina, chronic pharyngitis, bronchial pneumonia, viral pneumonia and other upper and lower respiratory tract infection diseases. Clinical studies have shown that the active ingredients contained in Yejuhua Injection are volatile fat-soluble small molecular substances extracted through double distillation, which are non-irritating to the respiratory mucosa, have no bitterness or peculiar smell, and...

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Abstract

The invention discloses application of Shanhaidan chrysanthemum indicum injection in aerosol inhalation, spray bottle aerial fog and rectal administration and a method. The method comprises the following steps: adding an osmotic pressure regulator with mass fraction of 0.2-0.3% in chrysanthemum indicum injection; regulating a pH value to be 6.3-6.8 by using a pH regulator; preparing an obtained solution into an aerosol inhalation preparation so that the aerosol inhalation preparation is directly inhaled into a respiratory system in an atomization mode; or placing the obtained solution in a spray bottle to obtain a spray bottle aerial fog preparation which is used for covering the respiratory system in a local spraying mode; or adding a rectal absorption enhancer in the chrysanthemum indicum injection and preparing into a rectal administration preparation with a pH regulator, wherein the rectal administration preparation enters blood circulation through haemorrhoidal veins. PH values and osmotic pressures of the three preparations in the invention meet requirements of physicochemical properties of the respiratory system and an intestinal environment, a respiratory tract and an intestinal tract are not irritated, and respiratory tract infection diseases caused by viruses, bacteria and drug-resistance bacteria can be clinically treated by the chrysanthemum indicum injection.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to the application and method of Shanhaidanye chrysanthemum injection in atomized inhalation, spray bottle aerosol and rectal administration. Background technique [0002] Wild chrysanthemum injection is produced from wild chrysanthemum, sodium chloride and polysorbate according to the scientific ratio, and is produced by advanced technologies such as secondary distillation, decoction, and secondary sterilization and filtration. Wild chrysanthemum injection, heat-clearing and detoxifying. It is used for exogenous febrile diseases, red eyes, swelling and pain, sore throat; upper respiratory tract infection and acute tonsillitis are heat-toxin attackers. [0003] At present, Yejuhua Injection is administered in the form of intramuscular injection in clinical practice, and there are treatment risks such as pain at the injection site, infection, broken needle, etc.,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/287A61K9/12A61K9/72A61K9/00A61P31/12A61P31/04A61P11/00A61P31/22A61P11/04
Inventor 翁晓伟李小兵
Owner 陕西医药控股集团山海丹药业股份有限公司
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