Fructose diphosphate containing novel pharmaceutical composition injection for treating circulation system diseases

Abstract

The invention provides an injection prepared from a novel composition which contains three medicines such as fructose diphosphate and the like, wherein the injection consists of the following components according to effective doses: 10-50g of the fructose diphosphate, 0.01-0.05g of isosorbide dinitrate and 100-1000ml of sodium hydrogen sulfite. The invention also provides preparation steps and a preparation method. The pharmaceutical composition is applicable to shock, coronary heart disease, angina, acute myocardial infarction, myocardial ischemia, cardiac failure and surrounding lesions. By adding the isosorbide dinitrate, myocardial oxygen consumption is reduced, oxygen supply is enhanced and the angina is relieved. In cooperation with and by expanding the application of the fructose diphosphate to clinical treatment, the medicine is safer and is more stable, and the medicine is capable of relieving irritant pain on a human body and enhancing a curative effect on treating circulation system related diseases. The preparation method comprises the following steps: sequentially stirring and dissolving the fructose diphosphate, the sodium hydrogen sulfite and the isosorbide dinitrate by virtue of injection water, decoloring with the addition of activated carbon, filtering and removing carbon; and filtering, sterilizing, filling and sterilizing.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a pharmaceutical composition injection containing sodium fructose diphosphate compound and a preparation method thereof. Background technique [0002] Fructose diphosphate (fructose-1,6-diphosphate, FDP) is a cell metabolite present in the human body, which can regulate the activity of various enzyme systems in glucose metabolism, improve the state of cell hypoxia and ischemia, and is beneficial to damage Recovery of liver cells. When the phosphate concentration in the circulating blood is lower than the normal concentration, it will cause phosphorus metabolism disorder, usually showing symptoms such as hemolysis, fatigue, weakness and convulsions, which is called hypophosphatemia (hypophosphatemia, also known as hypophosphatemia) ). There are many reasons for hypophosphatemia. Long-term infusion (glucose) can increase the uptake of phosphate by cells, which can lead to hypoph...

AI Technical Summary

Problems solved by technology

[0004] The common problem of sodium fructose diphosphate injection in intravenous infusion is pain. The main reason may be that sodium fructose diphosphate is an acidic liquid, which can cause spasm of vascular smooth muscle, resulting in pain and discomfort in local or punctured limbs; Sodium phosphate contains 5 hydrogen radicals. Due to the release of the pain-causing substance hydrogen ions, the hydrogen ions act on the nerve endings to generate pain-causing afferent impulses, so the incidence of pain is extremely high; fructose diphosphate sodium is a hypertonic sugar. It can dehydrate tissue cells, increase intercellular fluid, tissue edema, compress and stimulate peripheral nerves, and cause pain; in addition, particles in the liquid are also an important factor that causes infusion pain

So far, there is no effective solution to the pain of sodium fructose diphosphate infusion

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