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Artificial blood vessel and preparation method thereof and needling die

An artificial blood vessel and acupuncture technology, applied to blood vessels, devices with human tubular structures, non-woven fabrics, etc., can solve the problems of complex process, poor fabric resistance to penetration, easy damage to blood vessels, etc., to achieve firm bonding and improve penetration resistance Ability, the effect of improving mechanical strength

Active Publication Date: 2016-02-10
浙江脉通智造科技(集团)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method requires repeated electrospinning, and the process is complicated; the prior art also discloses a double-layer artificial blood vessel with an outer layer composed of a woven, knitted or braided structure and an inner layer composed of nanofibers
The nanofiber layer is prepared by electrospinning. After the spinning is completed, the surface where the nanofibers are collected is turned over to the inner layer to form the inner surface of the artificial blood vessel, but turning over is easy to damage the blood vessel.
[0005] The important problem existing in the existing artificial blood vessels is that the anti-permeability of the fabric is still relatively poor, and the mechanical strength is not enough

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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  • Artificial blood vessel and preparation method thereof and needling die
  • Artificial blood vessel and preparation method thereof and needling die
  • Artificial blood vessel and preparation method thereof and needling die

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preparation example Construction

[0027] figure 1 For the schematic flow chart of the preparation of the artificial blood vessel in the preferred embodiment of the present invention, please refer to figure 1 , the preparation method of the artificial blood vessel comprises the following steps:

[0028] Step S1: Cut the fabric and sew the fabric into a cylindrical shape with surgical sutures to form the inner wall of the blood vessel; the fabric can be polyester, spandex, silk, polytetrafluoroethylene or their blended materials; the cylindrical shape The diameter of the fabric is consistent with the required diameter of human blood vessels, and the preferred diameter range is 6mm-38mm.

[0029] Step S2: Set the stitched cylindrical fabric on a metal rod matching its diameter, and directly use the metal rod covered with the cylindrical fabric as the receiving end to perform electrospinning; make the nanofibers along the cylindrical shape The outer surface of the fabric grows in the circumferential direction an...

Embodiment 1

[0035] Cut the polyester woven fabric into a size of 100*30mm, sew it into a tube with a length of 100mm with surgical sutures, and wrap it on a metal rod of an appropriate size. The metal rod was used as the receiving end of the electrospinning equipment and rotated evenly at a speed of 50 r / min. The prepared 10% polylactic acid solution was electrospun. The spinning voltage is 15kV; the receiving distance is 15cm. After spinning is complete, the artificial vascular product is removed from the metal rod. Put the spun artificial blood vessel on a rubber rod of corresponding diameter, use a special acupuncture mold to acupuncture the artificial blood vessel, and rotate the artificial blood vessel to ensure uniform puncture.

Embodiment 2

[0037] Cut the silk woven fabric into a size of 100*20mm, sew it into a tube with a length of 100mm with surgical sutures, and wrap it on a metal rod of an appropriate size. The metal rod was used as the receiving end of the electrospinning equipment and rotated evenly at a speed of 50 r / min. The prepared 20% polyurethane solution was electrospun. The spinning voltage is 12kV; the receiving distance is 20cm. After spinning is complete, the artificial vascular product is removed from the metal rod. Put the spun artificial blood vessel on the polyurethane rod of corresponding diameter, spunlace the artificial blood vessel with a special acupuncture mold, and rotate the artificial blood vessel to ensure uniform puncture.

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Abstract

The invention discloses an artificial blood vessel and a preparation method thereof and a needling die. The preparation method includes the following steps that fabric is clipped and sewn into a cylinder, and an inner-layer vessel wall of the blood vessel is formed; a metal rod is sleeved with the inner-layer vessel wall, the metal rod serves as an electrostatic spinning receiving end for electrostatic spinning, and nanofibers evenly adhere to the outer surface of the inner-layer vessel wall; when the nanofibers reach the preset thickness, spinning is stopped, an outer-layer vessel wall of the blood vessel is formed, and the artificial blood vessel is taken down from the metal rod; an elastic rod is sleeved with the artificial blood vessel, the artificial blood vessel is punctured, and the outer spinning layer and the inner layer are firmly combined. By means of the artificial blood vessel, the infiltration resistance and mechanical strength of the artificial blood vessel can be improved, and the advantages of resisting deformation and achieving high durability are achieved.

Description

technical field [0001] The invention relates to an implantable medical device, in particular to an artificial blood vessel, a preparation method thereof and a puncture mold. Background technique [0002] At present, cardiovascular disease and peripheral arterial disease are the main causes of human death in the world. Approximately 600,000 vascular grafts are performed each year, but nearly one-third of patients cannot use autologous blood vessels because of vascular aging, vascular disease, injury or previous surgical use. In this case, the use of artificial blood vessels has become a good choice. In the 1950s, since people observed the phenomenon of cells growing on silk immersed in blood, the history of fabricating artificial blood vessels began. Today, textile artificial blood vessels have been widely used clinically to replace damaged blood vessels in the human body, and have achieved good clinical results. But at the same time, textile artificial blood vessels also ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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Application Information

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IPC IPC(8): A61F2/06D04H1/728D04H1/76
Inventor 陈大凯杜广武丁峰罗七一
Owner 浙江脉通智造科技(集团)有限公司
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