Mannitol injection

A technology for injection and mannitol, applied in the field of pharmaceutical preparations, can solve the problems of unsatisfactory solubilization effect, weak dehydration effect of diabetic patients, low safety and the like, and achieves elimination of cerebral edema, improved stability and improved medication safety. Effect

Active Publication Date: 2016-02-03
GUANGXI YUYUAN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, although the chance of crystallization of mannitol glucose injection is extremely low, it is not suitable for diabetic patients, and its dehydration effect is weaker than that of ordinary mannitol injection.
In addition, improving the formula of mannitol injection and improving the crystallization of mannitol can also be achieved by adding co-solvents and other excipients, but generally the excipients with better solubilization are less safe, while the excipients with better safety have a solubilizing effect not ideal
From this point of view, mannitol injections with good curative effect and high safety without crystallization at low temperature are still very limited.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Mannitol injection is made from the following raw materials in percentage by weight:

[0019]

[0020] The preparation method of mannitol injection: take mannitol, cod liver oil and Tween 80 and dissolve in appropriate amount of water for injection; add 0.1% W / V activated carbon for needles, heat to boil, filter; add the remaining amount of water for injection, mix well Filter, fill and seal, and sterilize by autoclaving at 121°C for 15 minutes.

Embodiment 2

[0022] Mannitol injection is made from the following raw materials in percentage by weight:

[0023]

[0024] The preparation method of mannitol injection: take mannitol, cod liver oil and Tween 80 and dissolve in appropriate amount of water for injection; add 0.2% W / V activated carbon for needles, heat to boil, filter; add the remaining amount of water for injection, mix well Filter, fill and seal, and sterilize by autoclaving at 121°C for 15 minutes.

Embodiment 3

[0026] Mannitol injection is made from the following raw materials in percentage by weight:

[0027]

[0028] The preparation method of mannitol injection: take mannitol, cod liver oil and Tween 80 and dissolve in an appropriate amount of water for injection; add 0.3% W / V activated carbon for needles, heat to boil, filter; add the remaining amount of water for injection, mix well Filter, fill and seal, and sterilize by autoclaving at 121°C for 15 minutes.

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PUM

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Abstract

The invention relates to the technical field of pharmaceutical preparations, in particular to mannitol injection. The mannitol injection is prepared from, by weight, 9-16% of mannitol, 2-8% of cod-liver oil, 1-7% of Tween-80 and the balance water for injection. The mannitol injection is good in treatment effect, non-crystallizable at lower temperature and high in safety.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a mannitol injection. Background technique [0002] Mannitol is a kind of hexanehexol, which is an isomer of sorbitol. It is a good diuretic and dehydrating drug. It is used to treat cerebral edema and increased intracranial pressure caused by various reasons. It is also used in other eye-reducing diseases. When internal pressure medicine is ineffective or before intraocular surgery. At 20°C, the solubility of mannitol in water is 1:5.5 (18%), and 20% mannitol injection is a supersaturated solution. When the room temperature is lower than 15°C, mannitol particles are easily produced, and even crystals are precipitated. When the temperature continues to drop, the crystals increase in size and become large columnar and flocculent crystals. If the packaging is a plastic soft bag, it will cause damage and increase the risk of medication. The particles in the man...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/047A61K47/44A61K47/34A61P7/10A61P25/00
Inventor 庞春林罗世东王亚军陈兴华廖柳艳王敏
Owner GUANGXI YUYUAN PHARMA
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