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Solid dispersion for treating peptic ulcer

A solid dispersion, peptic ulcer technology, applied to the digestive system, medical preparations containing active ingredients, plant/algae/fungus/moss ingredients, etc. Good pain relief, improved anti-ulcer activity, and improved bioavailability

Inactive Publication Date: 2016-01-27
门源县雪草木生物药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the above-mentioned prescriptions have more medicinal flavors, a larger amount of medicinal materials, and higher costs

Method used

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  • Solid dispersion for treating peptic ulcer
  • Solid dispersion for treating peptic ulcer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] The preparation of embodiment 1 pharmaceutical composition of the present invention

[0024] Zushima 3g, Anisopolamine 0.5g, Dried Ginger 9g, Seabuckthorn 10g; after drying, crush to 300 mesh, mix evenly to get raw material medicine powder.

[0025] Take raw drug powder: polyethylene glycol-6000=1:1w / w, mix well, heat until polyethylene glycol-6000 is in a molten state, stir, immediately place in 0°C environment and quench until solidified, crush to obtain Solid dispersion.

Embodiment 2

[0026] The preparation of embodiment 2 pharmaceutical compositions of the present invention

[0027] Zushima 1g, Anisopolamine 0.6g, Dried Ginger 6g, Seabuckthorn 10g; after drying, crush to 400 mesh, mix evenly to get the raw material medicine powder.

[0028] Take raw drug powder: polyethylene glycol-6000=1:3w / w, mix well, heat until polyethylene glycol-6000 is in a molten state, stir, immediately place in 0°C environment and quench until solidified, crush to obtain Solid dispersion.

Embodiment 3

[0029] The preparation of embodiment 3 pharmaceutical composition of the present invention

[0030] Zushima 1g, anisopolamine 0.3g, dried ginger 10g, seabuckthorn 6g; after drying, crush into 500 meshes, and mix well to obtain the raw material medicine powder.

[0031] Take raw drug powder: polyethylene glycol-6000=3:1w / w, mix well, heat until polyethylene glycol-6000 is in a molten state, stir, immediately place in 0°C environment and quench until solidified, pulverize to obtain Solid dispersion.

[0032] The beneficial effects of the present invention are further demonstrated through specific test examples below.

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Abstract

The invention provides solid dispersion for treating peptic ulcer. The solid dispersion comprises raw material powder and polyethylene glycol-6000 according to a ratio of the raw material powder to the polyethylene glycol-6000 of 1-3:1-3w / w. The raw material powder comprises, by weight, 1-3 parts of daphne giraldii nitsche, 0.3-0.6 part of anisodus tanguticus, 6-10 parts of dried ginger and 6-10 parts of sea buckthorn, and the daphne giraldii nitsche, the anisodus tanguticus, the dried ginger and the sea buckthorn are ground to obtain the raw material powder with the size of 300-500 meshes. The solid dispersion has the advantages that the raw material powder is prepared to obtain the solid dispersion, accordingly, the bioavailability of medicines can be improved, and the anti-ulcer activity can be obviously improved.

Description

technical field [0001] The invention relates to a solid dispersion for treating peptic ulcer. Background technique [0002] Gastric and duodenal ulcers refer to localized round or oval full-thickness defects of gastric and duodenal mucosa, the muscularis mucosae is penetrated, and fibrous scars inevitably remain after healing, with a layer of epithelium on the surface Overlying, the muscularis mucosa cannot regenerate. The etiology can be summed up as the self-digestion of gastric mucosa by gastric acid and pepsin or the destruction of gastric mucosal barrier due to various reasons. In recent years, it has been considered that the formation of ulcers has an important relationship with Helicobacter pylori infection in the stomach. [0003] Chronic erosive gastritis, also known as verrucous gastritis or pimple-like gastritis, generally only sees dyspepsia symptoms such as fullness after meals, pantothenic acid, belching, and irregular abdominal pain. Multiple verrucous, enl...

Claims

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Application Information

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IPC IPC(8): A61K36/9062A61K47/34A61P1/04
Inventor 徐继锋卞海军许婧
Owner 门源县雪草木生物药业有限公司
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