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Subcutaneous tissue-intervening needle-like glucose sensor and preparation method thereof

A glucose sensor and subcutaneous tissue technology, applied in the field of sensors, can solve the problems of insufficient fixation of glucose oxidase, high structural compactness, poor catalytic efficiency, etc., to achieve mass production, improve stability and reliability, compact effect

Active Publication Date: 2016-08-31
杭州瀚科医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The present invention mainly solves the deficiencies in the prior art, such as insufficient fixed amount of glucose oxidase, low sensitivity, low stability, poor catalytic efficiency, poor anti-interference ability, etc., and proposes a sensor with high detection sensitivity and anti-interference Strong ability, good stability, high compact structure, small sensor size, large effective area, high corresponding signal, good anti-interference performance, long validity period, can better solve the problem of circuit conduction, stable and reliable, easy for mass industrial production Subcutaneous tissue-intervening needle-like glucose sensor and preparation method thereof

Method used

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  • Subcutaneous tissue-intervening needle-like glucose sensor and preparation method thereof

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Effect test

Embodiment 1

[0062] Embodiment 1: as figure 1 , figure 2 , image 3 , Figure 4 , Figure 5 , Figure 6 and Figure 7 As shown, a subcutaneous tissue-intervening needle-shaped glucose sensor includes a base 1, the bottom of the base 1 is provided with a working electrode 2, a counter electrode 3 and a reference electrode 4, and the working electrode 2, counter electrode The electrode 3 and the reference electrode 4 form a split needle-shaped three-electrode system;

[0063] The working electrode 2 includes a working substrate 5, the outer surface of the working substrate 5 is covered with a working inert metal layer 6, and the outer surface of the working inert metal layer 6 is covered with a working catalytic layer 7. The outer surface of the working catalytic layer 7 is covered with a working inner modified layer 8, the outer surface of the working inner modified layer 8 is covered with an enzyme layer 9, and the outer surface of the described enzyme layer 9 is covered with a work...

Embodiment 2

[0101] Embodiment 2: The preparation method of the subcutaneous tissue-intervening needle-shaped glucose sensor is carried out according to the following steps:

[0102] (1), preparation of working electrode:

[0103] The working electrode includes a working substrate, a working inert metal layer, a working catalytic layer, a working inner modification layer, an enzyme layer, a working modification layer, a working polymer layer, a working outer modification layer, and a working hydrophilic layer;

[0104] Working electrode dimensions, diameter 0.25mm, length 6mm or less;

[0105] Its preparation method is as follows:

[0106] ①. The material of the working substrate is metal or non-metal;

[0107] ②. The working inert metal layer is prepared by electroplating and sputtering;

[0108] ③. The working catalytic layer is platinum black, which can be prepared by electroplating;

[0109] ④. The solution used for the modified layer: the solvent is ethanol or tetrahydrofuran, the...

Embodiment 3

[0135] Embodiment 3: The preparation method of subcutaneous tissue-intervening needle-shaped glucose sensor is carried out according to the following steps:

[0136] (1), preparation of working electrode:

[0137] The working electrode includes a working substrate, a working inert metal layer, a working catalytic layer, a working inner modification layer, an enzyme layer, a working modification layer, a working polymer layer, a working outer modification layer, and a working hydrophilic layer;

[0138] Working electrode dimensions, diameter 0.3mm, length 6mm or less;

[0139] Its preparation method is as follows:

[0140] ①. The material of the working substrate is metal or non-metal;

[0141] ②. The working inert metal layer is prepared by electroplating and sputtering;

[0142] ③. The working catalytic layer is platinum black, which can be prepared by electroplating;

[0143] ④. The solution used for the modified layer: the solvent is ethanol or tetrahydrofuran, the solute...

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Abstract

The invention is a sensor, in particular to a subcutaneous tissue-intervening needle-shaped glucose sensor and a preparation method thereof. It includes a base, and the bottom of the base is provided with a working electrode, a counter electrode and a reference electrode, and the working electrode, the counter electrode and the reference electrode form a split needle-shaped three-electrode system. The subcutaneous tissue-intervening needle-like glucose sensor and the preparation method thereof have a compact structure, improved operation performance, and improved service life.

Description

technical field [0001] The invention is a sensor, in particular to a subcutaneous tissue-intervening needle-shaped glucose sensor and a preparation method thereof. Background technique [0002] Diabetes is a common endocrine and metabolic disease that seriously endangers human health worldwide. In recent years, the global prevalence of diabetes has shown a clear upward trend. For diabetic patients, blood sugar monitoring is very important, and corresponding treatment plans must be formulated according to the level of blood sugar. Since there are many factors that affect the blood sugar level of the human body, blood sugar fluctuates greatly, and the traditional single-point blood sugar measurement has obvious shortcomings. , hypoglycemia, affecting the health of patients, and even life-threatening in severe cases. [0003] In response to the above problems, domestic and foreign companies have researched and developed biosensors capable of continuously measuring blood gluc...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61B5/1486
Inventor 高春燕
Owner 杭州瀚科医疗科技有限公司
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