Stable compositions comprising heparinoid, acute-acting anesthetic, and buffer

Abstract

Improved methods for preparing compositions including a heparinoid, an acute-acting anesthetic, and a buffer are described. These methods result in compositions in which the heparinoid and the acute-acting anesthetic are at least 90% stable for one year. Compositions prepared by these methods and having such improved stability properties are also described, as well as methods for use of these compositions for treating, ameliorating, or preventing lower urinary tract disorders such as interstitial cystitis.

Description

[0001] References for related applications [0002] This case claims the priority right of the U.S. Provisional Application No. 61 / 757,592 filed by CL Parsons on January 28, 2013. The name of the provisional application: a stable composition containing heparinoids, emergency anesthetics and buffers, The disclosure content is incorporated herein by reference. Technical field [0003] The present invention relates to a stable composition, in particular to a composition comprising heparinoid, emergency anesthetic and buffer and a preparation method thereof. Background technique [0004] Interstitial cystitis (IC) is a chronic, progressive disease of the lower urinary tract that causes urgency and frequency of urination and / or pelvic pain. For many years, urologists considered interstitial cystitis to be a rare disease, and therefore, they did not have a broad and effective treatment. But in fact, the aforementioned diseases are quite common. In 1999, the prevalence of interstitial c...

AI Technical Summary

Problems solved by technology

However, the mixing of heparin, lidocaine and buffer solvents must be done in a precise manner to avoid precipitation of lidocaine, which in the above case would produce precipitation above pH 7, which would decrease its bioavailability, and reduce the efficacy of the composition

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