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Treatment method and treatment device for efficacy of combination medicine

A treatment method and a treatment device technology, which are applied in the field of biomedicine and can solve problems such as difficult determination of drug effects

Active Publication Date: 2018-03-02
INST OF RADIATION MEDICINE ACAD OF MILITARY MEDICAL SCI OF THE PLA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0029] The main purpose of the present invention is to provide a drug effect processing method and processing device for combined drugs to solve the technical problem in the prior art that it is difficult to determine the drug effect when multiple drugs are used in combination

Method used

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  • Treatment method and treatment device for efficacy of combination medicine
  • Treatment method and treatment device for efficacy of combination medicine
  • Treatment method and treatment device for efficacy of combination medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0195] Embodiment 1: the treatment method of the medicinal effect of two medicines in combination

[0196] 1) Drug NX and drug TX are used together in a fixed ratio;

[0197] 2) The fixed dose of drug TX is used in combination with different doses of drug NX.

[0198] Title: Nitroxyl compound (NX) is an anti-infective drug, which has been found to have targeted anti-cancer activity in recent years, and has been approved by SFDA to enter clinical trials; paclitaxel (TX) is a commonly used clinical anti-cancer drug. The combined application of NX / TX and MTT assay inhibited the growth of human hepatoma cells HepG2. The method for quantitatively processing synergistic / additive / antagonistic related indicators is described, which provides a reference for the research and development of new anti-cancer compounds.

[0199] The first part of NX / TX fixed ratio NX:TX = 1:1 (μg / ml+ng / ml) two drugs combined treatment method

[0200] Step 1: Make a dose-response relationship table of the...

Embodiment 2

[0310] Embodiment 2: the drug effect detection method of three medicines in combination

[0311] Topic: There are various application programs of chemotherapeutic drugs in the treatment of lung cancer. The chemotherapeutic drugs in these programs mainly include the following: from the types of chemotherapeutic drugs, they belong to topoisomerase inhibitors, microtubule inhibitors, metabolic inhibitors, alkylating agents and so on four categories. Select a representative drug from these four classes of drugs in turn, namely etoposide (A), vincristine (B), 5-fluorouracil (C), and doxorubicin (D), any three combined application regimens, The inhibitory effect on the growth of human lung cancer cell line H460 was detected by MTT assay. The three regimens are A+B+C, A+B+D, A+C+D, B+C+D and other four combined drug combinations in turn, and their synergistic, additive and antagonistic effects are quantitatively evaluated.

[0312] A+B+C combination: A:B:C=12.5:2:45(μg / ml+μg / ml+μg / ...

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Abstract

The present application provides a processing method and a processing device for the efficacy of a combination drug. The processing method includes: obtaining the dose-effect curve of the expected additive effect of the combination drug; obtaining the actual dose-effect relationship curve formed by the actual effect value of the combination drug with the dose change of a certain target component in the combination drug; comparing the actual The positional relationship between the dose-response curve and the dose-response curve, and when the actual dose-response curve is above the dose-response curve, the drug effect of the combination drug is output as synergy; When it is below, the output of the drug effect of the combination drug is antagonism; when the actual dose-effect relationship curve is within the range of the dose-effect curve, the output of the drug effect of the combination drug is added. The processing method not only solves the problem that the efficacy of multiple drugs cannot be accurately detected in the prior art, but also can be widely used in the research and development of compound drugs, toxicology research, efficacy and safety evaluation of combined drugs and environmental evaluation.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular, to a treatment method and treatment device for the efficacy of a combined drug. Background technique [0002] The current basic path of new drug research and development is to screen for candidate compounds and optimize leads for a disease-related target, and then conduct drugability research, preclinical evaluation and clinical trials before approval for marketing. This research model based on "single target, single disease, single drug", especially the development of single-structure compound drugs targeting a single target, is becoming more and more difficult in terms of therapeutic use. The etiology of many major intractable diseases is usually multi-target and multi-link, and it is necessary to target multiple links in order to be effective, and it is almost a difficult task to develop new compounds and drugs with a single structure targeting multiple links. From the feasibility an...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G16H20/10
CPCG16C20/30G16H70/40G16H20/10G16Z99/00G06N7/00
Inventor 袁守军
Owner INST OF RADIATION MEDICINE ACAD OF MILITARY MEDICAL SCI OF THE PLA
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