Compound eye drops used before ophthalmologic operation and preparing method thereof

An eye drop and compound technology, which is applied in the field of ophthalmic preoperative compound eye drops and its preparation, can solve problems such as reducing work efficiency, increasing nurse workload, and reducing patient comfort, so as to improve efficiency and safety, The effect of avoiding the risk of contamination and reducing the number of prescriptions

Inactive Publication Date: 2016-01-06
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

On the one hand, patients need to order more than 10 consecutive doses of medicine within half an hour, which reduces the patient's comfort and is likely to cause drug-induced ocular surface toxicity; on the other hand, drug storage and cross-use are prone to drug contamination and even cross-infection , a serious threat to the safety of surgery
Frequent ordering of medicines also increases the workload of nurses and reduces work efficiency

Method used

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  • Compound eye drops used before ophthalmologic operation and preparing method thereof
  • Compound eye drops used before ophthalmologic operation and preparing method thereof
  • Compound eye drops used before ophthalmologic operation and preparing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028]

[0029] Its preparation process:

[0030] (1) Proparacaine hydrochloride was weighed in proportion, added to water for injection at 100°C, stirred until dissolved, placed, and the temperature dropped to 50-60°C to obtain solution 1;

[0031] (2) Weigh tropicamide and phenylephrine hydrochloride in proportion, add them to water for injection at 100° C., stir until dissolved, and let the temperature drop to 50-60° C. to obtain solution 2;

[0032] (3) Weigh sodium hyaluronate in proportion, add it to water for injection at 100°C, stir until it dissolves, and place it until the temperature drops to 50-60°C to obtain solution 3;

[0033] (4) Add solution 2 and solution 3 to the obtained solution 1, stir, add buffer salt, isotonic regulator and pH regulator, supplement water for injection to the specified amount, mix well, and the pH value is 6-7.5;

[0034] (5) Filling after ultrafiltration sterilization, each tube is 0.4mL.

Embodiment 2

[0036]

[0037] Its preparation process: the consumption of sodium hyaluronate is changed to 2g, and the operation method is the same as in Example 1.

Embodiment 3

[0039]

[0040] Its preparation process: the consumption of sodium hyaluronate is changed to 3g, and the operation method is the same as in Example 1.

[0041] A compound eye drop for ophthalmic preoperative use of the present invention, through a stability test, the stability, pH value, sterility, microbial content limit, identification and measurement of the eye drop all meet the requirements.

[0042] A kind of ophthalmic preoperative compound eye drop of the present invention, animal acute toxicity test data shows, after using this eye drop to rabbit cornea, corneal epithelium is complete, and fluorescein staining is negative, and the result shows that repeated administration has no effect on corneal epithelium. damage.

[0043] For the rabbit eye irritation test, refer to the relevant regulations on pre-clinical research in the "New Drug Approval Measures" of the Ministry of Health of the People's Republic of China, and use the one-time drop method to conduct the rabbi...

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PUM

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Abstract

The invention discloses compound eye drops used before an ophthalmologic operation and a preparing method thereof. The eye drops are prepared from, by weight, 5 mg/ml proparacaine hydrochloride, 5 mg/ml tropicamide, 5 mg/ml phenylephrine hydrochloride, 1-3 mg/ml sodium hyaluronate, buffer salt, isoosmotic adjusting agent, pH modifier and water for injection. By the adoption of the compound eye drops used before an ophthalmologic operation, mydriasis and surface anesthesia can be achieved, the workload of nurses is effectively relieved, and the working efficiency of nurses is improved.

Description

technical field [0001] The invention relates to the technical field of ophthalmic medication of pharmaceutical preparations, in particular to a compound eye drop for ophthalmic preoperative use and a preparation method thereof. Background technique [0002] The eye is an important organ of vision. With the aging of the population, the incidence of cataract and various fundus diseases is increasing year by year, seriously affecting people's visual health. A considerable number of patients need surgical treatment, and medical needs and standards are also improving. Cataract, retinal detachment, vitreous hemorrhage and fundus laser operations account for more than 80% of routine ophthalmic operations. These patients require mydriasis and topical anesthesia to prepare the operated eye prior to surgery. The method currently adopted is to order mydriatic medicine and superficial anesthetic 4-6 times respectively within half an hour before the operation. Each eyedrop package is ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/728A61K9/08A61P23/02A61P27/08A61K31/4409A61K31/245A61K31/137
Inventor 侯旭王雨生胡丹周健蔡莉崔志利
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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