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Dimercaprol fat emulsion injection

A technology of dimercaprol and injection, applied in the field of medicine

Active Publication Date: 2021-12-14
FUBICHENG SHANGHAI PHARMA TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, not all insoluble drugs can be made into fat emulsion injection, and there may also be problems such as drug precipitation during dilution, pain at the injection site or phlebitis, and toxicity of additives to the human body.

Method used

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  • Dimercaprol fat emulsion injection
  • Dimercaprol fat emulsion injection
  • Dimercaprol fat emulsion injection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0067] The raw material composition of dimercaprol fat emulsion injection: 5 grams of dimercaprol, 45 grams of soybean oil, 20 grams of egg yolk lecithin, 10 grams of glycerol, 5 grams of EDTA, add 100 grams of water for injection.

[0068] Preparation of the batching system: the whole batching system is sterilized with boiling water at 115°C, the air in the whole batching system is removed, and replaced with nitrogen, so repeated 3 times;

[0069] Preparation of spare water: Put an appropriate amount of water for injection into the colostrum tank, fill with nitrogen to expel oxygen, keep warm at 2530°C, and set aside;

[0070] Preparation of the water phase: Take 10% water for injection and glycerin, put it in the water phase tank, sterilize at 115°C for 15 minutes, cool down to 25°C, pass through the filter and mix with spare water evenly, continue to fill with nitrogen to drive oxygen, add sodium hydroxide solution Mix evenly, keep warm at 25°C, and set aside;

[0071] Pre...

Embodiment 2

[0078] The raw material composition of dimercaprol fat emulsion injection: 5 grams of dimercaprol, 45 grams of soybean oil, 20 grams of egg yolk lecithin, 5 grams of sodium oleate, 10 grams of glycerin, 5 grams of EDTA, add 100 grams of water for injection.

[0079] Preparation of the water phase: Take 10% water for injection, glycerin, EDTA, put in the water phase tank, sterilize at 115°C for 15 minutes, cool down to 25°C, pass through the filter and mix with spare water evenly, continue to fill with nitrogen to drive oxygen, add hydroxide Mix the sodium solution evenly, keep warm at 25°C, and set aside;

[0080] Preparation of the oil phase: steam-dry the oil phase tank, weigh dimercaprol, soybean oil, and sodium oleate in the oil phase tank, turn on nitrogen to bubble from the bottom, stir evenly, heat to 45°C, and Slowly add egg yolk lecithin under protection, and stir at high speed until the egg yolk lecithin is evenly dispersed;

[0081] All the other preparation steps ...

Embodiment 3

[0083] The raw material composition of dimercaprol fat emulsion injection: 5 grams of dimercaprol, 45 grams of soybean oil, 20 grams of egg yolk lecithin, 5 grams of oleic acid, 10 grams of glycerol, 5 grams of EDTA, add 100 grams of water for injection.

[0084] Preparation of the water phase: Take 10% water for injection, glycerin, EDTA, put in the water phase tank, sterilize at 115°C for 15 minutes, cool down to 25°C, pass through the filter and mix with spare water evenly, continue to fill with nitrogen to drive oxygen, add hydroxide Mix the sodium solution evenly, keep warm at 25°C, and set aside;

[0085] Preparation of oil phase: Dry the oil phase tank with steam, weigh dimercaprol, soybean oil, and oleic acid in the oil phase tank, turn on nitrogen to bubble from the bottom, stir evenly, heat to 45°C, and place under the protection of nitrogen flow Slowly add egg yolk lecithin and stir at high speed until the egg yolk lecithin is evenly dispersed;

[0086] All the oth...

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Abstract

The present invention relates to a dimercaprol fat emulsion injection, which is composed of the following components: 1-10 grams of dimercaprol, 20-50 grams of soybean oil, 10-40 grams of lecithin, 4-10 grams of glycerin, EDTA1 ‑10 grams, 850‑990 grams of water for injection.

Description

technical field [0001] The invention belongs to the technical field of medicine, specifically, the invention mainly relates to a dimercaprol fat emulsion injection and a preparation method thereof. Background technique [0002] Dimercaptopropanol is an almost colorless and easy flowing liquid, acidic, with a specific gravity of 1.238-1.240, and a stench like onion and garlic (general mercapto compounds have this smell). It can be slowly oxidized in the air to reduce the content. The solubility in water is 1:13, but it is easy to decompose and fail in aqueous solution. It can be dissolved in benzyl benzoate and can increase co-stability. Therefore, benzyl benzoate and sesame oil are often used as solvents when preparing injections (< Pharmaceutical Bulletin>, Volume 5 Issue 5). Dimercaprol Injection is mainly used for the treatment of arsenic, mercury and gold poisoning, and it is used in combination with edetate calcium sodium to treat children with acute lead enceph...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/107A61K31/095A61K47/44A61K47/24A61K47/22A61K47/18A61P39/02
Inventor 曹亮甘莉刘月华
Owner FUBICHENG SHANGHAI PHARMA TECH CO LTD
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