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Method for preparing surface-enhanced Raman scattering (SERS) substrate

A substrate and substrate surface technology, applied in the direction of Raman scattering, material excitation analysis, etc., can solve the problems of preparation time, raw material cost, and sensitivity that are difficult to coordinate and unify, and achieve simple and reliable process, improved reduction performance, and good reproducibility Effect

Active Publication Date: 2015-12-16
CHENGDU SCI & TECH DEV CENT CHINA ACAD OF ENG PHYSICS
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] The purpose of the present invention is to overcome the difficulties in coordination and unification of the preparation time, raw material cost, sensitivity, etc. in the preparation process of the SERS substrate in the prior art, and to provide a mild and green SERS substrate preparation method

Method used

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  • Method for preparing surface-enhanced Raman scattering (SERS) substrate
  • Method for preparing surface-enhanced Raman scattering (SERS) substrate
  • Method for preparing surface-enhanced Raman scattering (SERS) substrate

Examples

Experimental program
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Embodiment 1

[0052] Take the melanin film and put it into 0.05M silver nitrate solution, under the simulated sunlight conditions (light intensity 50W / m 2 ) to stand and soak for 12 hours. After the reaction, the surface was washed with absolute ethanol and secondary water to remove the silver nitrate solution on the surface to obtain the Ag / melanin active substrate.

[0053] This Ag / melanin / ITO active substrate is used to detect Nair blue (NBA) solution, and the obtained Raman spectrum is as follows figure 2 shown.

Embodiment 2

[0055]Take the melanin film and put it into 0.05M chloroauric acid solution, under the simulated sunlight conditions (light intensity 700W / m 2 ) standing and soaking for 1 h, after the reaction, the surface was washed with absolute ethanol and secondary water to remove the surface chloroauric acid solution, and the Au / melanin active substrate was obtained for SERS detection.

Embodiment 3

[0057] according to figure 1 The preparation flow procedure shown prepares the SERS substrate, specifically as follows:

[0058] (1) Preparation of melanin film

[0059] Weigh 0.0080g (0.04mmol) L-dopa and place it in the electrolytic cell, add 17mL Tris-HCl buffer solution with pH=7.50 and 3mL ethanol mixed solution, ultrasonically disperse for 10min, and obtain the melanin precursor after it is completely dispersed. as an electrolyte. The setting parameters of electrochemical cyclic voltammetry are: the scanning voltage is E=-0.8V~+0.8V, the scanning rate is 50mV / s, and the number of scanning cycles is 75. Use ITO as the working electrode, Pt sheet as the counter electrode, and a saturated calomel electrode as the reference electrode. The area of ​​the Pt sheet is more than twice that of the ITO area. After electrochemical deposition, rinse the melanin film with absolute ethanol and secondary water. The unreacted melanin precursor solution was removed from the surface to...

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Abstract

The invention provides a method for preparing a surface-enhanced Raman scattering (SERS) substrate. The method utilizes a melanin membrane as a key substrate surface morphology control layer on the SERS substrate and utilizes metal nanoparticles prepared from a melanin reduction metal salt solution to prepare the SERS substrate. Through reduction effects of a melanin organic molecule functional group, a metal ion is directly reduced into a metal nanoparticle and the metal nanoparticle is deposited on the surface of the melanin film, and through control of an effective area and density of the organic molecule functional group and reaction conditions of metal ion reduction into an atom and polymerization of atoms into a nanometer cluster, metal nanoparticle sizes and distance are adjusted and controlled so that metal nanoparticle / melanin film SERS performances are optimized. The method is used for detection of trace quantity of substances. A detected sample is directly put on the metal nanoparticle-loaded melanin film so that detection is finished. The method is free of a reduction additive in metal nanoparticle reduction, has good response enhancement effects on SERS detection and is not influenced by a background interference element.

Description

technical field [0001] The invention belongs to the technical field of Raman spectrum detection, and specifically relates to a SERS substrate prepared by using light to induce and regulate melanin film reduction metal nanoparticles and a preparation method thereof. Background technique [0002] Surface-enhanced Raman Scattering (SERS) technology is a new generation of detection technology developed on ordinary Raman. Compared with ordinary Raman scattering technology, surface-enhanced Raman scattering technology has the characteristics of good selectivity and high sensitivity, and can realize the detection of single molecules. In recent years, it has become a common method in the fields of environmental monitoring, biochemical sensing, and disease diagnosis. means of analysis. [0003] The application basis of SERS technology is the highly sensitive SERS "hot spot" formed by the active substrate with high sensitivity. The currently commonly used SERS active substrate is us...

Claims

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Application Information

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IPC IPC(8): G01N21/65
Inventor 刘焕明黄家伟王群王聪周玉凤唐昶宇程凡圣梅军
Owner CHENGDU SCI & TECH DEV CENT CHINA ACAD OF ENG PHYSICS
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