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Test paper for detecting allergen-specific IgE antibody in tear sample

A technology in allergens and samples, applied in measuring devices, instruments, disease diagnosis, etc., to achieve strong specificity, high sensitivity, and convenient detection

Inactive Publication Date: 2015-12-09
中眼研德(北京)医疗技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The current commonly used test strips for detecting allergen-specific IgE antibodies in tear samples have many defects and need to be further improved

Method used

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  • Test paper for detecting allergen-specific IgE antibody in tear sample
  • Test paper for detecting allergen-specific IgE antibody in tear sample
  • Test paper for detecting allergen-specific IgE antibody in tear sample

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Such as figure 1 and figure 2 As shown, a test paper for detecting allergen-specific IgE antibodies in tear samples, the pH value of the test paper is 6.4, which consists of an absorbent pad 1, a sample pad 2, a colloidal gold reagent pad 3, a cellulose film 4, and an adhesive layer 5 , a polystyrene base plate 6 and two tempered glass side plates 7, wherein:

[0033] The adhesive layer 5 is fixed on the polystyrene bottom plate 6;

[0034] The cellulose film 4, the water-absorbing pad 1 and the colloidal gold reagent pad 3 are fixed on the adhesive layer 5;

[0035] The cellulose membrane 4 is provided with a quality control line 41 and a detection line 42, and the cellulose membrane 4 is a nitrocellulose membrane;

[0036] The sample pad 2 is arranged on the colloidal gold reagent pad 3, and the sample pad 2 is a reticular fiber membrane;

[0037] The two tempered glass side plates 7 are symmetrically fixed on both sides of the end of the test paper where the wat...

Embodiment 2

[0042] Such as figure 1 and figure 2 As shown, a test paper for detecting allergen-specific IgE antibodies in tear samples, the pH value of the test paper is 7.7, which consists of water-absorbing pad 1, sample pad 2, colloidal gold reagent pad 3, cellulose film 4, and adhesive layer 5 , a polystyrene base plate 6 and two tempered glass side plates 7, wherein:

[0043] The adhesive layer 5 is fixed on the polystyrene bottom plate 6;

[0044] The cellulose film 4, the water-absorbing pad 1 and the colloidal gold reagent pad 3 are fixed on the adhesive layer 5;

[0045] The cellulose membrane 4 is provided with a quality control line 41 and a detection line 42, and the cellulose membrane 4 is a cellulose acetate membrane;

[0046] The sample pad 2 is arranged on the colloidal gold reagent pad 3, and the sample pad 2 is a reticular fiber membrane;

[0047] The two tempered glass side plates 7 are symmetrically fixed on both sides of the end of the test paper where the water-...

Embodiment 3

[0052] Such as figure 1 , figure 2 , image 3 , Figure 4 and Figure 5 As shown, a test paper for detecting allergen-specific IgE antibodies in a tear sample, the pH value of the test paper is 7.0, which consists of an absorbent pad 1, a sample pad 2, a colloidal gold reagent pad 3, a cellulose film 4, and an adhesive layer 5 , a polystyrene base plate 6 and two tempered glass side plates 7, wherein:

[0053] The adhesive layer 5 is fixed on the polystyrene bottom plate 6;

[0054] The cellulose film 4, the water-absorbing pad 1 and the colloidal gold reagent pad 3 are fixed on the adhesive layer 5;

[0055] The cellulose membrane 4 is provided with a quality control line 41 and a detection line 42, and the cellulose membrane 4 is a nitrocellulose membrane;

[0056] The sample pad 2 is arranged on the colloidal gold reagent pad 3, and the sample pad 2 is a reticular fiber membrane;

[0057]The two tempered glass side plates 7 are symmetrically fixed on both sides of t...

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Abstract

The invention relates to a test paper for detecting allergen-specific IgE antibody in a tear sample. The pH value of the test paper is 6.4-7.7, and the test paper is composed of an absorbent pad, a sample pad, a colloidal gold reagent pad, a cellulose membrane, an adhesive layer, a polystyrene baseboard and two toughened glass side boards, wherein the adhesive layer is fixedly arranged on the polystyrene baseboard; the cellulose membrane, the absorbent pad and the colloidal gold reagent pad are fixedly arranged on the adhesive layer; the cellulose membrane is provided with a quality control line and a detection line; the sample pad is arranged on the colloidal gold reagent pad; and the two toughened glass side boards are symmetrically and fixedly arranged at two sides of one end of the test paper provided with the absorbent pad. An advanced allergen immunochromatography technique is adopted to qualitatively determine the specific IgE antibody in the tear sample in order to detect the tear sample, and the test paper has the advantages of noninvasiveness and harmlessness to human bodies, high sensitivity, strong specificity, convenient detection and simple convenient, can complete full detection within 10-15min, is convenient to popularize and use, and can well meet needs of practical application.

Description

technical field [0001] The invention belongs to the technical field of immunochromatography detection, and in particular relates to a test paper for detecting allergen-specific IgE antibodies in tear samples. Background technique [0002] Immunochromatography is a unique immunoassay method that appeared in the early 1980s. It often uses strip-shaped fiber chromatography materials as the solid phase, and the sample solution swims on the chromatography strip through capillary action, and at the same time makes the sample solution The analyte and the receptor (such as antibody or antigen) for the analyte on the chromatographic material have a highly specific and high-affinity immune reaction, and the immune complex is enriched or trapped in the chromatographic material during the chromatography In a certain area (detection zone), an intuitive experimental phenomenon (such as color development) can be obtained by enzymatic reaction or direct use of a visual marker (such as collo...

Claims

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Application Information

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IPC IPC(8): G01N33/558
CPCG01N33/558G01N2800/24
Inventor 陶勇白夏冰吴悦明杨利明安杰张文博
Owner 中眼研德(北京)医疗技术有限公司
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