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Antrodia camphorata anetisone composition for treating liver cancer and its preparation method

A technology for the treatment of liver cancer and a composition, which is applied in the field of pharmaceutical compositions for the treatment of liver cancer, can solve the problems of high price of the composition, little research on the composition of Antrodia camphorata, and no one has studied it, so as to achieve good therapeutic effect, enhance the vitality of liver cells, good repeatability

Active Publication Date: 2019-04-09
LIAOCHENG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The patent application number 200510044806.1 discloses an anti-liver cancer Antrodia camphorata capsule and its preparation method; the patent application number 201310088358.X discloses the composition of Antrodia camphorata fruiting body and broken ganoderma spore powder and its role in immune regulation Antrodia camphorata fruiting bodies and Ganoderma lucidum spore powder are relatively expensive medicines, and the resulting composition is relatively expensive, and cannot be consumed and purchased by families with ordinary incomes; the patent application number 201010502077.0 discloses the anticancer active substances of Antrodia camphorata, Preparation method and its use; In addition, there are other patents on the extraction method of the anticancer active substances of Antrodia cinnamomea. There are relatively few studies on the composition of Antrodia camphorata, especially for the composition of how to improve the efficacy of Antrodia camphorata.

Method used

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  • Antrodia camphorata anetisone composition for treating liver cancer and its preparation method
  • Antrodia camphorata anetisone composition for treating liver cancer and its preparation method

Examples

Experimental program
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Effect test

Embodiment 1

[0024] A composition of antrodia antrodia fenethione for treating liver cancer, the components and parts by weight of the composition include 22 parts of Antrodia camphorata, 4 parts of anetisone, 18 parts of microcrystalline cellulose, 0.7 parts of polysorbate, carboxymethyl 17 parts of base starch sodium, 0.3 parts of micronized silica gel.

[0025] A preparation method of antrodia antrodia fennelsulfur composition for treating liver cancer, the specific steps comprising:

[0026] 1) preparing materials, preparing materials according to the components and parts by weight described in a kind of Antrodia camphorata anetisone composition for treating liver cancer;

[0027] 2) Extraction of the active ingredient triterpenes of Antrodia camphorata: crush Antrodia camphorata through a 200-mesh sieve, add 4 times the volume of alcohol of Antrodia camphorata to the ultrasonic extraction tank, the alcohol mass concentration is 95%, add the crushed Antrodia camphorata to ultrasonic ex...

Embodiment 2

[0034] A composition of antrodia antrodia anethione for treating liver cancer, the composition and parts by weight include 20 parts of antrodia camphorata, 3 parts of anetthio, 15 parts of compressible starch, 0.5 parts of fatty acid sorbitan, low-substituted 15 parts of hydroxypropyl cellulose, 0.1 part of talcum powder.

[0035] A preparation method of antrodia antrodia fennelsulfur composition for treating liver cancer, the specific steps comprising:

[0036] 1) preparing materials, preparing materials according to the components and parts by weight described in a kind of Antrodia camphorata anethiol composition for treating liver cancer;

[0037]2) Extraction of the active ingredient triterpenes of Antrodia camphorata: crush Antrodia camphorata through a 200-mesh sieve, add 4 times the volume of alcohol of Antrodia camphorata to the ultrasonic extraction tank, the alcohol mass concentration is 95%, add the crushed Antrodia camphorata to ultrasonic extraction In the tank, ...

Embodiment 3

[0044] A composition of antrodia camphorata anetis for treating liver cancer, the composition and parts by weight include 25 parts of Antrodia camphorata, 5 parts of anetis, 20 parts of powdered sugar, 1 part of polyoxyethylene fatty acid ester, 20 parts of polyvinylpyrrolidone, 0.5 parts of magnesium stearate.

[0045] A preparation method of antrodia antrodia fennelsulfur composition for treating liver cancer, the specific steps comprising:

[0046] 1) preparing materials, preparing materials according to the components and parts by weight described in a kind of Antrodia camphorata anetisone composition for treating liver cancer;

[0047] 2) Extraction of the active ingredient triterpenes of Antrodia camphorata: crush Antrodia camphorata through a 200-mesh sieve, add 4 times the volume of alcohol of Antrodia camphorata to the ultrasonic extraction tank, the alcohol mass concentration is 95%, add the crushed Antrodia camphorata to ultrasonic extraction In the tank, sonicate ...

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Abstract

The invention discloses an antrodia camphorata and anethol trithione composition for treating liver cancer and a preparation method of the antrodia camphorata and anethol trithione composition. The composition consists of the following components in parts by weight: 20-25 parts of antrodia camphorata, 3-5 parts of anethol trithione, 15-20 parts of a thinner, 0.5-1 part of a surfactant, 15-20 parts of a disintegrating agent and 0.1-0.5 parts of a lubricant. The preparation of the composition comprises steps of material preparation, extraction of active ingredients of antrodia camphorata, wet granulation, granule straightening and tabletting. The composition disclosed by the invention, by organically combining two medicines, namely antrodia camphorata and anethol trithione, can reduce the category of crude medicines and the dosage of pharmaceutical adjuvants. On the basis of the effect of the antrodia camphorata on inhibiting liver cancer, the anethol trithione is capable of promoting the recovery of hepatic cells, and the antrodia camphorata and the anethol trithione take a significant synergistic effect to effectively treat liver cancer. The composition can be used for avoiding the defect of lowered immunity of patients of cancer due to side effect caused by chemotherapy. The composition disclosed by the invention is simple in preparation process, easy in industrial production, convenient to take and capable of improving the compliance of patients; therefore, the composition is better in treatment effect.

Description

technical field [0001] The invention belongs to the field of pharmaceutical compositions for treating liver cancer, in particular to an antrodia antrodia anetisone composition for treating liver cancer and a preparation method thereof. Background technique [0002] Antrodia camphorata (Antrodia camphorata) is a unique rare medicinal fungus in my country, and it is exclusively parasitic on the camphor tree. The chemical composition of Antrodia camphorata is very complex. Modern separation technology has proved that Antrodia camphorata contains anti-cancer, anti-cancer, and immune-enhancing properties. Physiologically active substances, the main components are polysaccharides and triterpenoids. Triterpenoids are the most terpenoid chemical components found in the fruiting bodies of Antrodia camphorata, and are generally considered to be the main source of bitter components in Antrodia camphorata extracts. Among them, as many as 10 newly discovered triterpenoids are unique to A...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/07A61P35/00A61K31/385
Inventor 陈坤陈芳刘静张宇叶会会
Owner LIAOCHENG UNIV
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