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Traditional Chinese medicine composition for treating prostate cancer, and preparation method and application of traditional Chinese medicine composition

A prostate cancer and composition technology, which is applied in the direction of drug combinations, pharmaceutical formulas, medical preparations containing active ingredients, etc., can solve problems such as overlap and increase production costs, reduce adverse reactions, simplify prescriptions, and have good application prospects Effect

Active Publication Date: 2015-12-02
SHANGHAI ZHONGYAO BIO TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In fact, the effects of several components are similar, which increases the production cost
CN1478538 discloses a traditional Chinese medicine composition for the treatment of prostate cancer, but Folium Folium and Radix Ordinaris both have the effect of inhibiting tumors, Chrysanthemum and Scutellaria baicalensis both have the effect of clearing away heat and detoxifying, and similar effects overlap, which also increases the production cost

Method used

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  • Traditional Chinese medicine composition for treating prostate cancer, and preparation method and application of traditional Chinese medicine composition
  • Traditional Chinese medicine composition for treating prostate cancer, and preparation method and application of traditional Chinese medicine composition

Examples

Experimental program
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Effect test

Embodiment 1

[0053] (1) Preparation of raw materials: Ganoderma lucidum, Scutellaria baicalensis, Radix radix hibiscus, Panax notoginseng and licorice are pulverized and mixed in proportions of 3 kilograms, 2 kilograms, 2 kilograms, 1 kilogram and 1 kilogram by weight, and the mixture of Chinese medicines is divided into six equal parts;

[0054] (2) extract alkaloids:

[0055] i) percolating or leaching a portion of the traditional Chinese medicine mixture obtained in step (1) with 0.1% hydrochloric acid ethanol solution to obtain an acidic ethanol extract;

[0056] ii) concentrating under reduced pressure to obtain a concentrate;

[0057] iii) washing with acidic water (pH=4-5), filtering to obtain a residue, washing the residue with acidic water to obtain an acidic aqueous solution;

[0058] iv) adding ammonia water for precipitation to the acidic aqueous solution obtained in step iii), and filtering to obtain the total alkaloid precipitation;

[0059] or a) adding dilute acid to the...

Embodiment 2

[0072] 1) extract baicalin:

[0073] i) Add 10 times (volume) amount of water to 1.5 kg of Scutellaria baicalensis and decoct for 1 hour, filter;

[0074] ii) Adjust the pH of the filtrate to 2 with an acid, keep it at 80°C for 30 minutes, and centrifuge to precipitate; add water and stir the precipitate evenly, add alkali to adjust the pH to neutral, then add 5 times (volume) of ethanol, and filter;

[0075] iii) Add hydrochloric acid to the filtrate, adjust the pH to 2, stir, keep at 80°C for 30 minutes, and filter;

[0076] iv) The obtained precipitate was washed with water and 50% ethanol respectively, and then washed with 95% ethanol or recrystallized to obtain baicalin.

[0077] 2) extract notoginseng saponins:

[0078] i) 40% methanol was used to extract the soluble components in 1.5 kg of Panax notoginseng coarse root powder, the methanol extract was concentrated under reduced pressure, and 5 times (volume) of water was added to the residue;

[0079] ii) The aqueous...

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Abstract

The invention relates to a traditional Chinese medicine composition for treating prostate cancer, and a preparation method and application of the traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from the following raw materials: ganoderma lucidum, radix scutellariae, rabdosia rubescens, panax notoginseng and liquorice according to a weight ratio of 2-3:1-2:1-2:0.5-1.5:0.5-1.5. The traditional Chinese medicine composition is prepared by mixed extracting or object extracting. Components of the composition are simplified, quality control is facilitated, production cost is reduced, a curative effect of products is not affected, and the application prospect is good.

Description

technical field [0001] The invention belongs to the field of prostate cancer treatment, in particular to a traditional Chinese medicine composition for treating prostate cancer, its preparation method and application. Background technique [0002] Prostate cancer (PCA) is one of the most common malignant tumors in men. In European and American countries, prostate cancer has become the most common type of male cancer, and its mortality rate is second only to lung cancer. In recent years, with the gradual aging of the population in my country and the improvement of people's living standards and quality of life, the incidence and mortality of prostate cancer have also shown a rapid upward trend year by year. The research and drug development of prostate cancer have become the most popular in the world. one of the subjects. [0003] Prostate cancer can be divided into two types: sex hormone-dependent and non-sex hormone-dependent. The usual laser irradiation from the outside, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/539A61P35/00
CPCA61K36/53A61K2236/33A61K2236/331A61K2236/333A61P35/00A61K31/352A61K31/704A61K31/7048A61K36/074A61K36/258A61K36/484A61K36/539A61K2300/00A61K2236/51A61K2236/53
Inventor 杨亿泓
Owner SHANGHAI ZHONGYAO BIO TECH CO LTD
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