Pharmaceutical composition with nerve cell protective effect

A nerve cell protection and composition technology, applied in the field of traditional Chinese medicine, can solve problems such as protection, and achieve the effects of removing negative factors, enhancing the expression of GFAP, and reducing the formation of glial scars

Inactive Publication Date: 2015-12-02
JINAN XINGYI MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] According to the existing public technical information, there is no effective drug for the treatment of ischemic stroke based on nerve cell protection

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Embodiment 1: The pharmaceutical composition and preparation method thereof with nerve cell protection

[0034] The composition and parts by weight of the bulk drug of the pharmaceutical composition with nerve cell protection are:

[0035] Artemisia stifolium 35 parts by weight Catalpa pod powder 12.5 parts by weight Sylvia 7.5 parts by weight Bell bell japonica 5 parts by weight of Chinese fir flavonoids 1.5 parts by weight Cypress biflavones 1 parts by weight;

[0036] Preparation:

[0037] (1) According to the ratio of raw materials, take catalpa pod powder and styloid flower, mix well, crush, pass through a 60-mesh sieve, use supercritical carbon dioxide extraction technology, extraction temperature 38 ℃, extraction pressure 25MPa, extraction time 3h, collect the extract , to obtain extract A;

[0038] (2) According to the proportion of raw materials, take Artemisia stifolium and Cinnamon bell, mix well, use ethanol with a concentration of 50% as solvent, and extr...

Embodiment 2

[0040] Embodiment 2: The pharmaceutical composition and preparation method thereof with nerve cell protection

[0041] The composition and parts by weight of the bulk drug of the pharmaceutical composition with nerve cell protection are:

[0042] 30 parts by weight of Artemisia annua, 15 parts by weight of catalpa pod powder, 5 parts by weight of cypress, 6 parts by weight of bell bell, 1 part by weight of cypress biflavone, 1.5 parts by weight of cypress biflavone;

[0043] Preparation:

[0044](1) According to the ratio of raw materials, take catalpa pod powder and styloid flower, mix well, crush, pass through a 60-mesh sieve, use supercritical carbon dioxide extraction technology, extraction temperature 38 ℃, extraction pressure 25MPa, extraction time 3h, collect the extract , to obtain extract A;

[0045] (2) According to the proportion of raw materials, take Artemisia stifolium and Cinnamon bell, mix well, use ethanol with a concentration of 50% as solvent, and extract ...

Embodiment 3

[0047] Embodiment 3: the pharmaceutical composition and preparation method thereof with nerve cell protection

[0048] The composition and parts by weight of the bulk drug of the pharmaceutical composition with nerve cell protection are:

[0049] 40 parts by weight of Artemisia annua, 10 parts by weight of catalpa pod powder, 10 parts by weight of cypress flower, 4 parts by weight of bell bell, 2 parts by weight of cypress biflavone, 0.5 part by weight of cypress biflavone;

[0050] Preparation:

[0051] (1) According to the ratio of raw materials, take catalpa pod powder and styloid flower, mix well, crush, pass through a 60-mesh sieve, use supercritical carbon dioxide extraction technology, extraction temperature 38 ℃, extraction pressure 25MPa, extraction time 3h, collect the extract , to obtain extract A;

[0052] (2) According to the proportion of raw materials, take Artemisia stifolium and Cinnamon bell, mix well, use ethanol with a concentration of 50% as solvent, and...

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PUM

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Abstract

The invention discloses a pharmaceutical composition with a nerve cell protective effect. The pharmaceutical composition disclosed by the invention is prepared from artemisia hedinii, kamala, lomatogonium carinthiacum, anaphalis hancockii, amentoflavone and hinokiflavone as raw medicines in proportion, is extracted by adopting supercritical extraction and optimized modern extraction processes, and can be prepared into various dosage forms according to conventional preparation processes. The pharmaceutical composition provided by the invention overcomes the defects of the prior art, has the nerve cell protective effect, has an obvious curative effect and is safe.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine, and in particular relates to a pharmaceutical composition with nerve cell protective effect. Background technique [0002] Population aging has become a global problem, and it is becoming increasingly prominent in our country. With the intensification of population aging, neurodegenerative diseases have increasingly become a major problem that plagues modern people's lives. The main pathological changes of these diseases are the reduction and loss of neurons in the central nervous system, resulting in neurological and cognitive dysfunction. At present, there is still no effective treatment for this kind of disease, which has developed into a difficult problem that directly affects personal life and social development. Most of these diseases are caused by the destruction of the oxidation-reduction balance of nerve cells, triggering oxidative stress, and affecting cell proliferation, d...

Claims

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Application Information

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IPC IPC(8): A61K36/51A61P9/10A61P25/00A61K31/352
Inventor 张秀华
Owner JINAN XINGYI MEDICAL TECH
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