A method for identifying medicinal excipients added in Cordyceps sinensis products

Abstract

The invention discloses a method for identifying medicinal auxiliary materials added to Cordyceps sinensis products. The method comprises the following steps: grinding the Cordyceps sinensis product into fine powder, dissolving in water and adding iodine test solution dropwise; if the solution is blue or blue-black, then Add 20% sulfuric acid aqueous solution, water bath, and centrifuge. If the solution does not appear blue or blue-black, directly water bath and centrifuge; add iodine test solution dropwise to the supernatant; add zinc chloride iodine test solution to the lower precipitate. The identification process of the present invention does not require the use of expensive analytical instruments, and the method is simple, fast and effective; the entire identification process only requires a single sampling to simultaneously determine whether there are three auxiliary materials in the Cordyceps sinensis product: starch, povidone and microcrystalline cellulose.

Description

technical field [0001] The invention relates to a method for identifying medicinal auxiliary materials added to Cordyceps sinensis products. Background technique [0002] Cordyceps sinensis is a rare and precious medicinal material in my country. It has a long history of consumption in China. It is mainly used to treat kidney deficiency, impotence and nocturnal emission, waist and knee pain, chronic cough and shortness of breath, and cough and hemoptysis due to labor. Because of its good medicinal efficacy and health value, it is deeply sought after by people. At present, many Cordyceps sinensis tablets on the market claim to be pure powder tablets of Cordyceps sinensis. However, because the pure powder of Cordyceps sinensis contains more fiber and oily ingredients, the compressibility is not ideal, which directly leads to the poor compression effect of Cordyceps sinensis powder and the hardness of the product. High, easy to loose pieces, cracks or loose pieces, the yield i...

AI Technical Summary

Problems solved by technology

[0003] There are few methods for identifying the three excipients of starch, povidone and microcrystalline cellulose in Cordyceps sinensis products. The general method can only identify one of the excipients at a time. At present, there is no literature report that can simultaneously identify whether it is added by a single sampling The method of two or three excipients

And single sampling identification is faced with the mutual interference problem of various auxiliary materials identification, as: (1) starch aqueous solution meets iodine test solution and turns blue or blue black, and microcrystalline cellulose aqueous solution reacts with zinc chloride iodine test solution to form insoluble Blue floc of water, when the two exist at the same time, the blue floc cannot appear in blue or blue-black solution, and starch will interfere with the judgment of the presence or absence of microcrystalline cellulose

(2) Povidone reacts with iodine test solution to produce a reddish-brown precipitate. After shaking well, the precipitate dissolves into a reddish-brown solution; The blue or blue-black solution makes it impossible to observe the reddish-brown precipitate, and the starch will interfere with the judgment of the presence or absence of povidone

(3) When microcrystalline cellulose and povidone exist at the same time, after adding zinc chloride iodine test solution, blue insoluble flocs and reddish-brown precipitates are mixed, and it is impossible to clearly determine the presence or absence of the two, and povidone will interfere with microcrystalline cellulose. Judgment of presence or absence of crystalline cellulose