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Lycium ruthenicum anthocyanin crude extract and controlled-release microcapsule thereof

A technology of slow-release microcapsules and black fruit wolfberry, which is applied in food science, drug combination, drug delivery, etc., can solve the problems of insoluble, high cost, and easy to degrade fat-soluble substances, and achieve high production efficiency and production The effect of readily available materials and good antioxidant activity

Active Publication Date: 2015-11-25
CHINA ACAD OF SCI NORTHWEST HIGHLAND BIOLOGY INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Based on the above problems, the present invention aims to provide a crude extract of Lycium barbarum anthocyanins with antioxidant activity, so as to avoid the high cost of purifying anthocyanin monomer compounds; , under high temperature and strong acidic conditions, it is easy to degrade and cannot be dissolved in fat-soluble substances. The present invention also hopes to provide a sustained-release microcapsule preparation of the crude extract, thereby improving the stability of the main component anthocyanins. And prolong the action time of anthocyanins from black fruit wolfberry in the body

Method used

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  • Lycium ruthenicum anthocyanin crude extract and controlled-release microcapsule thereof
  • Lycium ruthenicum anthocyanin crude extract and controlled-release microcapsule thereof
  • Lycium ruthenicum anthocyanin crude extract and controlled-release microcapsule thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0039] Example 1: Preparation of crude extract of Lycium barbarum anthocyanins

[0040] The fresh or dried fruit of Lycium barbarum is used as raw material, crushed, and reflux extracted with 60% acidified ethanol (0.3% v / v HCl) at 50° C. for three times, each time for 2 hours. Filtrate was collected by filtration, concentrated under reduced pressure at 50°C, and the gained extract was dissolved in distilled water and then absorbed by X-5 macroporous resin for 24h, washed with water of 3 column volumes, and then acidified ethanol (0.3% v / v of HCl) to elute, collect the ethanol eluent, concentrate under reduced pressure and freeze-dry to obtain the crude extract of Lycium barbarum anthocyanins.

Embodiment 2

[0041] Example 2 Preparation of crude extract of Lycium barbarum anthocyanins

[0042] The fresh or dried fruit of wolfberry black fruit is used as the raw material, crushed, and reflux extracted with 55% acidified ethanol (0.2% v / v HCl) at 55°C for three times, each time for 3 hours. Filtrate was collected by filtration, concentrated under reduced pressure at 50°C, and the gained extract was dissolved in distilled water and then absorbed by X-5 macroporous resin for 24h, washed with water of 3 column volumes, and then acidified ethanol (0.2% v / v of HCl) analysis, the eluate was collected, concentrated under reduced pressure and freeze-dried to obtain the crude extract of Lycium barbarum anthocyanins.

Embodiment 3

[0043] Example 3 Preparation of slow-release microcapsules of crude extract of Lycium barbarum anthocyanins

[0044] According to the ratio of sodium alginate to crude Lycium barbarum anthocyanins (prepared in Example 1) ratio of 2:1, weigh sodium alginate and crude anthocyanins, dissolve them in water, and make the mass concentration of sodium alginate be 3% to obtain solution A; according to a certain oil-water ratio (1:2), add solution A to the salad oil containing Span80 (volume fraction of Span80: 6%), high-speed emulsification until uniform, and then add Tween80 high-speed emulsion ; centrifuge, get the supernatant, add mass concentration of 3% CaCl 2 solution is solidified, and the CaCl 2 The mass ratio with sodium alginate is 1: 2, the solidification time is 45min, and the microspheres are collected by centrifugation; they are washed with distilled water and isopropanol respectively, and a chitosan acetic acid solution (PH is 5.5) with a mass concentration of 5% is ad...

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Abstract

The invention provides a lycium ruthenicum anthocyanin crude extract and a controlled-release microcapsule thereof. The anthocyanin crude extract has good antioxidant activity, so that the further purification for an anthocyanin monomeric compound is prevented, and meanwhile, a preparation method is simple and convenient, production materials are easily available, and the production and use costs of the lycium ruthenicum anthocyanin are reduced. The controlled-release microcapsule is an eight-hour controlled-release capsule, the drug release is uniform in speed and complete, the bioavailability of the drug is improved, and the utilization ratio of the drug is guaranteed.

Description

technical field [0001] The invention relates to crude extract of anthocyanin from Lycium barbarum and its slow-release microcapsules. Background technique [0002] According to the Tibetan medical classics "Jingzhu Materia Medica" and "Four Medical Classics", it is recorded that black fruit wolfberry is sweet in taste, flat in nature, clears heart heat, and is used to treat heart fever, heart disease, irregular menstruation, and menopause. "Uyghur Medicine Chronicle" records: black fruit wolfberry fruit can treat diseases such as urethral calculus, ringworm and scabies, bleeding gums, etc., and it is used as nourishing and strong, improving eyesight and antihypertensive medicine among the people. These biological activities of Lycium barbarum are related to the anthocyanins it contains. Modern medical research has proved that anthocyanins from Lycium barbarum have the effects of lowering blood fat, regulating immunity, treating cardiovascular diseases, anti-arteriosclerosis...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/815A61K9/52A61K47/36A61P39/06A23L1/30
Inventor 丁晨旭张秋龙刘斌马涛胡娜索有瑞
Owner CHINA ACAD OF SCI NORTHWEST HIGHLAND BIOLOGY INST
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