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Application of forsythin aglycone in preparing medicine for preventing or treating liver injury or liver failure

A technology for forsythiaglycoside and liver damage, applied in the field of medicine, can solve the problems of weak targeted drug administration and life-threatening, achieve low toxic and side effects of the human body, improve drug safety and drug compliance, and improve treatment effect and quality of life effects

Inactive Publication Date: 2015-11-25
LUNAN PHARMA GROUP CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] With the rapid development of medical technology, although there have been many studies and reports on drugs for the treatment of liver damage, some studies have shown that some anti-liver damage drugs will inevitably produce biological toxicity, which is dangerous to life, and targeted drug delivery not strong

Method used

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  • Application of forsythin aglycone in preparing medicine for preventing or treating liver injury or liver failure
  • Application of forsythin aglycone in preparing medicine for preventing or treating liver injury or liver failure
  • Application of forsythin aglycone in preparing medicine for preventing or treating liver injury or liver failure

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Example 1 Forsythiagenin Injection

[0024]

[0025] Preparation process: mix the prescribed amount of propylene glycol and ethanol evenly, add forsythiagenin, stir to dissolve, add the prescribed amount of 0.9% sodium chloride solution, stir evenly, add 0.5% activated carbon for needles, stir, decarbonize, and obtain .

Embodiment 2

[0026] Example 2 Forsythiagenin Injection

[0027]

[0028] Preparation process: add forsythiagenin to the prescribed amount of PEG-400, stir to dissolve, add 0.9% sodium chloride solution to 10L, stir evenly, add 0.5% activated carbon for needles, stir, decarbonize, and obtain.

Embodiment 3

[0029] Example 3 Forsythiagenin Injection

[0030]

[0031] Preparation process: mix the prescribed amount of ethanol and Tween-80 evenly, add forsythinin, stir to dissolve, add water for injection to 10L, stir evenly, add 0.5% activated carbon for needles, stir, decarbonize, and obtain.

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Abstract

The invention discloses application of fructus forsythiae aglycone in preparing a medicament for preventing or treating liver injury or liver failure, and belongs to the medical field. The fructus forsythiae aglycone is a traditional Chinese medicine monomer obtained by extracting from the conventional fructus forsythiae, and is shown to have better treatment effect for the liver injury caused by acetaminopben, the livery injury caused by anti-tumor drug cis-platinum, acute or chronic livery injury caused by carbon tetrachloride, the livery injury caused by D-galactosamine and the liver failure caused by the D-galactosamine and lipopolysaccharide according to an animal test, has effect, which is better than that of fructus forsythiae and fructus forsythiae aglycone, in treating liver injury or liver failure. The fructus forsythiae aglycone is exact in curative effect and low in side effect for treating the liver injury and the liver failure, and has wide medical application prospect.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to the medical application of forsythiagenin, in particular to the medical application of forsythiagenin in the preparation of medicines for preventing or treating liver damage or liver failure. Background technique [0002] As the most important detoxification organ, the liver is an important target of many drugs and exogenous chemicals. Liver injury is the result of various liver diseases, and it is the initiating link and common path for the occurrence, development and eventual hepatic failure of many serious liver diseases. Among them, chemical liver injury, immune liver injury and physical liver injury Various liver injuries such as liver disease are serious frequently-occurring common diseases in my country at present. The pathogenesis of liver injury is very complex, which is the result of multi-factors, multi-layers, and multi-targets, mainly caused by drugs, alcohol, organisms, viruse...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/34A61P1/16A61P29/00
Inventor 赵志全姚景春冯芹刘艳松胡海勋王现珍
Owner LUNAN PHARMA GROUP CORPORATION
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