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Application of sevoflurane to preparing nerve regeneration promoting medicine

A technology of nerve regeneration and sevoflurane, applied in the field of biomedicine, can solve the problems of lack of understanding of the impact of infarction area, and no clear report on the impact of nerve regeneration and repair process, so as to reduce the difference between groups and accelerate the reconstruction of nerve function , the effect of promoting nerve regeneration

Inactive Publication Date: 2015-11-25
AFFILIATED HUSN HOSPITAL OF FUDAN UNIV +1
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  • Application Information

AI Technical Summary

Problems solved by technology

So far, studies on the neuroprotection of sevoflurane have focused on the ischemic penumbra area, lack of understanding of its effect on the infarct area, and there is no clear report on the effect of sevoflurane on nerve regeneration and repair after nerve injury

Method used

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  • Application of sevoflurane to preparing nerve regeneration promoting medicine
  • Application of sevoflurane to preparing nerve regeneration promoting medicine
  • Application of sevoflurane to preparing nerve regeneration promoting medicine

Examples

Experimental program
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Effect test

Embodiment 1

[0068] Embodiment 1 Animal experiment

[0069] 1. Focal cerebral ischemia model in rats

[0070]Adult male SD rats (280-320 g) were fasted for 12 hours before the operation and had free access to water. Give 2% pentobarbital sodium (45mg / kg) anesthesia by intraperitoneal injection, place on the rat operating table at constant temperature, routine fixed treatment, expose the right common carotid artery and internal carotid and external carotid branches, ligate the common carotid artery and the external carotid, A 3-0 single-strand nylon suture was inserted into the middle cerebral artery from the common carotid through the neck, and the suture was pulled out after occlusion for 120 minutes, and reperfusion was resumed. In the sham operation group, only surgical operations were performed without suture insertion, and intraoperative monitoring was performed. The rectal temperature of the rats was maintained at 37-37.5°C with a constant temperature operating table, and they were ...

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Abstract

The invention belongs to the field of biomedical science, and particularly relates to application of sevoflurane to preparing nerve regeneration promoting medicine. The application has the advantages that neuron regeneration promoted by means of sevoflurane pretreatment is studied and observed by the aid of immunofluorescence staining and laser confocal methods via focal cerebral ischemia models of rats, nerve functional reconstruction procedures after focal cerebral ischemia of the rats are accelerated, as shown by results, large quantities of newborn neurons are available in infarction regions of the rats at early injury stages after the rats are pretreated by the sevoflurane, and the quantities of the newborn neurons are obviously higher than those of untreated groups; synaptic connection and newborn myelin sheath formation are available among newborn neurons of the rats at middle-late injury stages; as proved by the results, effects of promoting post-stroke nerve regeneration and accelerating nerve functional reconstruction of the infarction regions can be realized under pretreatment actions of the sevoflurane; theoretical bases are provided for treating acute nerve injury and neurodegenerative diseases by the sevoflurane; the sevoflurane can be used for preparing the nerve regeneration promoting medicine and is particularly applicable to preparing medicine for promoting nerve regeneration after focal cerebral ischemia injury.

Description

technical field [0001] The invention belongs to the field of biomedicine, and relates to a new drug application of sevoflurane, in particular to the application of sevoflurane in the preparation of drugs for promoting nerve regeneration, especially the use of sevoflurane in the preparation of drugs for promoting nerve regeneration after focal cerebral ischemic injury in rats. Use in regenerative medicine. Background technique [0002] The prior art discloses that stroke is the second most common cause of death worldwide and the leading cause of disability in adults. Stroke causes large areas of brain tissue necrosis, and the failure of necrotic nerve tissue to regenerate is the main reason for the disability of patients. Therefore, actively looking for effective stroke intervention strategies in medical research, promoting nerve regeneration, repairing and rebuilding damaged brain tissue, alleviating the residual dysfunction of stroke patients, and promoting healthy recover...

Claims

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Application Information

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IPC IPC(8): A61K31/08A61P25/00
Inventor 余琼李丽梁伟民赛音贺西格
Owner AFFILIATED HUSN HOSPITAL OF FUDAN UNIV
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