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Mesoporous organosilica nanospheres with double-layer egg yolk-eggshell structure and preparation method thereof

A technology of organic silicon oxide and nanospheres, which is applied in the field of nanomaterials to achieve the effect of simple synthesis process, simple synthesis method and low equipment requirements

Active Publication Date: 2018-01-09
NANJING UNIV OF POSTS & TELECOMM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the synthesis of organosilica with a double-layer egg yolk-eggshell structure with different organic groups in the inner and outer layers has not yet been reported in articles or published in patents.

Method used

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  • Mesoporous organosilica nanospheres with double-layer egg yolk-eggshell structure and preparation method thereof
  • Mesoporous organosilica nanospheres with double-layer egg yolk-eggshell structure and preparation method thereof
  • Mesoporous organosilica nanospheres with double-layer egg yolk-eggshell structure and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] (1) Dissolve 0.08g of surfactant in a mixed solution containing 1ml of ammonia water, 30ml of ethanol and 75ml of water, and mix 0.25ml of tetraethyl orthosilicate and 0.1ml of bis[γ- (Triethoxysilyl) propyl] tetrasulfide mixture was added to the above mixed solution, reacted for 24h, the tetraethyl orthosilicate, surfactant, bis[γ-(triethoxysilyl ) Propyl] tetrasulfide, ethanol and water molar ratio 1:0.1:0.18:461:3728, wherein the NH contained in the ammonia 3 The mass percentage is 26%.

[0035](2) Centrifuge the mixed solution of step (1), wash with alcohol, transfer to the mixed solution of 1ml ammonia water, 29ml ethanol and 70ml water, add 0.1g surfactant, 0.125ml tetraethyl orthosilicate, 0.1ml of 1.2 -bis(triethoxysilyl)ethane, reacted for 24h at 35°C under stirring at 1100rpm, the tetraethyl orthosilicate, 1.2-bis(triethoxysilyl)ethane, surface The molar ratio of the active agent, water and ethanol is 1:0.5:0.5:7000:900, wherein the NH contained in the ammon...

Embodiment 2

[0040] (1) Dissolve 0.16g of surfactant in a mixed solution containing 1ml of ammonia water, 30ml of ethanol and 75ml of water, and mix 0.25ml of tetraethyl orthosilicate and 0.1ml of bis[γ- (Triethoxysilyl) propyl] tetrasulfide mixture was added to the above mixed solution, reacted for 24h, the tetraethyl orthosilicate, surfactant, bis[γ-(triethoxysilyl ) Propyl] the molar ratio of tetrasulfide, ethanol and water is 1:0.4:0.18:461:3728, wherein the NH contained in the ammonia 3 The mass percentage is 26%.

[0041] (2) Centrifuge the mixed solution of step (1), wash with alcohol, transfer to a mixed solution containing 1ml of ammonia, 30ml of ethanol and 75ml of water, add 0.16g of surfactant, 0.125ml of tetraethyl orthosilicate and 0.12 ml of 1.2-bis(triethoxysilyl)ethane was reacted for 12 hours at 35°C under the condition of stirring at 1200rpm. The tetraethyl orthosilicate, 1.2-bis(triethoxysilyl)ethane The molar ratio of alkanes, surfactants, water and ethanol is 1:0.6:...

Embodiment 3

[0046] (1) Dissolve 0.2g surfactant in a mixed solution of 1ml ammonia water, 30ml ethanol and 75ml water, mix 0.25ml tetraethyl orthosilicate and 0.1ml bis[γ-( Triethoxysilyl) propyl] tetrasulfide mixture is added to the above-mentioned mixed solution, reacted for 3h, the tetraethyl orthosilicate, surfactant, bis[γ-(triethoxysilyl) The molar ratio of propyl]tetrasulfide, ethanol and water is 1:0.5:0.18:461:3728. NH contained in ammonia water 3 The mass percentage is 26%.

[0047] (2) Centrifuge the mixed solution of step (1), wash with alcohol, transfer to the mixed solution of 1ml ammonia water, 32ml ethanol and 90ml water, add 0.18g surfactant, 0.125ml tetraethyl orthosilicate and 0.14ml 1.2-bis(triethoxysilyl)ethane, reacted for 3h at 35°C and 500rpm stirring, the tetraethyl orthosilicate, 1.2-bis(triethoxysilyl)ethane , the molar ratio of surfactant, water and ethanol is 1:0.7:0.9:9000:1000, wherein the NH contained in the ammonia 3 The mass percentage is 26%.

[004...

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Abstract

The invention discloses a mesoporous organo-silicon oxide nanosphere with a double-layer egg yolk-eggshell structure and a preparation method thereof. The layer contains thioether bonds, the outer layer contains ethane groups, and both the inner layer and the outer layer have mesoporous channels. The present invention adopts two kinds of organosilicon sources, and sequentially adds organosilane bis[γ-(triethoxysilyl) containing sulfide bond (-(CH3)3-S4-(CH3)3-) to the reaction solution Propyl]tetrasulfide, and organosilane 1.2-bis(triethoxysilyl)ethane containing ethane group (‑CH2‑CH2‑), the introduction of these two organosilicon sources makes the synthesized organic Silica has good hydrothermal stability and chemical activity; moreover, the mesoporous silica ball has regular shape, uniform size, no agglomeration between particles, and a large cavity between the inner and outer layers, which has good Its dispersibility and biocompatibility have great application potential in catalysis, drug delivery, etc.

Description

technical field [0001] The invention relates to a mesoporous organic silicon oxide nanosphere with a double-layer egg yolk-eggshell structure and a preparation method, belonging to the field of nanomaterials. Background technique [0002] Mesoporous silica nanomaterials are one of the most promising carriers in the field of drug and gene delivery. Organosilica nanomaterials prepared using bridging organosilanes as precursors have the properties of both organic and inorganic materials, which can control the drug release rate and realize the biodegradability of drug carriers, which has become a research hotspot in the field of drug carrier materials. However, the preparation of mesoporous organosilica with a variety of organic groups and hollow structures still faces great challenges. [0003] The mesoporous silica material with egg yolk-eggshell structure has good biocompatibility, high specific surface area, uniform pore size and large cavity, showing great application pros...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01J13/02B01J20/22B01J20/30B01J31/02B01J35/10B82Y40/00B82Y30/00
Inventor 汪联辉张俊杰翁丽星滕兆刚
Owner NANJING UNIV OF POSTS & TELECOMM
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