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Refining optimization technology for crude heparin sodium

A technology of heparin sodium and crude product is applied in the refining and optimization process field of crude heparin sodium, which can solve the problems such as difficulty in obtaining high-quality heparin sodium products, unsuitable reaction conditions, damage to the structure of heparin sodium, etc., and achieves high product yield, shortened production cycle, The effect of increasing the rate of enzymatic hydrolysis

Inactive Publication Date: 2015-10-28
JIANGSU LIANZHONG CASING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Due to the difficulty in controlling the amount of oxidant added and the reaction conditions in the prior art, excessive oxidant is often added, and the reaction conditions are not suitable, causing damage to the structure of heparin sodium, resulting in low yield and low activity, and it is difficult to obtain higher purity. Boutique Heparin Sodium Products

Method used

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Embodiment Construction

[0019] The implementation of the present invention will be illustrated by specific specific examples below, and those skilled in the art can easily understand other advantages and effects of the present invention from the contents disclosed in this specification.

[0020] An optimization process for refining crude heparin sodium. After crushing and screening, dissolving, enzymatic hydrolysis, filtration, oxidation and precipitation, drying and dehydration, the process for refining and optimizing crude heparin sodium is completed. The specific steps are as follows:

[0021] (1) Grinding and screening: crush the crude heparin sodium first, then sieve, and crush the larger particles again;

[0022] (2) Dissolving: Put the pretreated crude heparin sodium into water, add sodium chloride solution, and stir with a mixer;

[0023] (3) Enzymolysis: add trypsin to the dissolved mixed liquid, adjust the pH value to 7-9, and heat to 40-60°C, and the enzymolysis time is 3-6 hours;

[0024...

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Abstract

The invention discloses a refining optimization technology for crude heparin sodium. The refining optimization technology for the crude heparin sodium is characterized in that the technology is finished through crushing and screening, dissolution, enzymolysis, filtration, oxidation and precipitation as well as drying and dehydration. The invention discloses a new refining technology for the crude heparin sodium. Through control on the addition amount of an oxidizing agent, namely, hydrogen peroxide, and oxidizing times, combined refinement of heparin sodium is realized with methods of impurity removal through adsorption and enzymolysis, impurity removal is more thorough, an enzyme activator is added, the enzymolysis rate is greatly increased, the enzyme consumption is reduced, the production cycle is shortened, the production cost is reduced, industrial production is facilitated, purification and decoloring processes are finished more quickly and effectively, operation is simple, the production cycle is short, the product yield is high, the quality is reliable, and refined heparin sodium with the better color can be obtained after purification.

Description

technical field [0001] The invention relates to the field of biotechnology, in particular to an optimization process for refining crude heparin sodium. Background technique [0002] Heparin sodium is the sodium salt form of heparin, which is a natural anticoagulant substance of acidic mucopolysaccharides containing sulfate groups. It can be widely used to prevent and treat various cardiovascular and cerebrovascular diseases, and is widely favored in clinical applications. Heparin sodium is widely present in the intestinal mucosa, lung, and liver of mammals, especially in the small intestinal mucosa of pigs. Heparin sodium has a strong anticoagulant effect, and is the drug of choice for preventing deep venous thrombosis and other thromboembolic diseases. , anti-allergic, anti-viral, anti-cancer and other biological functions. my country is the country with the largest output of heparin sodium. More than 70% of the raw materials of heparin sodium in the international market...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/10
Inventor 顾永军
Owner JIANGSU LIANZHONG CASING
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