Purification method for moxidectin

Abstract

The invention provides a purification method for moxidectin. The purification method comprises the steps: mixing a moxidectin crude product with a solvent and adding an antioxidant; stirring the mixture at 60-80 DEG C to prepare a solution; and then adding a solventing-out reagent and finally drying mixture under the vacuum condition through cooling crystallization to obtain high purity moxidectin with the purity being over 96%. The purification method for moxidectin provided by the invention has the advantages of short crystallization time, low cost and high yield and provides a novel method for improving the purity of moxidectin.

Description

technical field [0001] The invention provides a method for purifying moxidectin, which belongs to the field of medicinal chemistry. Background technique [0002] Moxidectin is a semi-synthetic single-component macrolide antibiotic produced by the fermentation of Streptomyces, and it is a derivative of nimoxectin. Macrolide antiparasitic drugs consist of two major classes, abamectins and milbemycins. Compared with ivermectin and avermectin, moxidectin has wider anthelmintic activity, long-term effect and safety characteristics. In the mid-1980s, moxidectin began to be used as an anthelmintic for animals. As a new generation of anthelmintic drug, moxidectin can effectively kill nematodes and ectoparasites, and has good safety to animals. It is superior to ivermectin in terms of dosage, dosage form development, drug resistance and drug distribution in vivo. At present, moxidectin is a broad-spectrum, high-efficiency, new macrolide anthelmintic antibiotic widely used in vete...

AI Technical Summary

Problems solved by technology

This method takes a long time, the yield is low, and the product purity is not significantly improved; ②The column chromatography purification method mentioned in the Chinese patent CN101372492A, this method can obtain moxidectin with a purity of more than 90%, but consumes a large amount of organic Solvent, the production cycle is long, resulting in high cost and low production capacity; ③ the methods disclosed in US Patent No. This method can produce moxidectin with a purity of more than 94%, but the boiling points of methylcyclohexane and n-heptane are very close, so that the solvent cannot be recycled and used, and the cost is high; ④ Chinese patent CN 103601735 A mentions the use of n-heptane Heptane crystallized and purified moxidectin under the condition of adding seed crystals, but the product purity did not increase significantly