Method for refining salbutamol sulfate

Abstract

The invention relates to a method for refining salbutamol sulfate and belongs to the technical field of fine chemical separation and purification. The method for refining the salbutamol sulfate aims to achieve the technical purposes that the technique is simple and the purity of refined products is high. According to the technical scheme, the method for refining the salbutamol sulfate comprises the steps that crude salbutamol sulfate is dissolved in purified water, filtering is conducted, and thus salbutamol sulfate filter liquor is obtained for later use, wherein the weight ratio of the salbutamol sulfate and water is 1:3.6; acetone with the weight being three times to four times that of the crude salbutamol sulfate is added into the filter liquor, and crystallization is conducted for four hours at the normal temperature; crystallized liquor is poured into a centrifugal machine, the liquor is added multiple times in the way that a small amount of liquor is added each time, the centrifugal machine is started till no liquor flows out from a discharge outlet, and a filter cake is washed by means of acetone till the filter liquor is clear; centrifugation continues to be conducted for half an hour, the centrifugal machine is stopped, and discharging is conducted; a centrifuged wet product is contained in a clean stainless steel tray and evenly spread flat, and the acetone is naturally dried for more than three hours; the tray is placed in a drying box to be dried for more than four hours by controlling the temperature to be 70-80 DEG C, and then sieving is conducted by means of a 40-mesh sieve.

Description

technical field [0001] The invention relates to a method for refining albuterol sulfate, which belongs to the technical field of separation and purification of fine chemicals. Background technique [0002] Salbutamol sulfate is called 1-(4-hydroxy-3-hydroxymethylphenyl)-2-(tert-butylamino)ethanol sulfate, which is suitable for bronchial asthma, wheezing bronchitis and emphysema, etc. Mists are inhaled, while prophylaxis can be given orally. The main function is to selectively excite the β2-receptor on the bronchial smooth muscle, relax the bronchial smooth muscle, and relieve the spasm of the bronchial smooth muscle. Adverse reactions: Mainly stimulate the heart and central nervous system, such as headache, dizziness, insomnia, occasionally muscle and finger tremors, palpitations, blood pressure fluctuations, etc. Long-term use can produce drug resistance and may aggravate asthma. [0003] In the quality standard of salbutamol sulfate contained in the first supplement of ...

AI Technical Summary

Problems solved by technology

The quality standards of salbutamol sulfate stipulated in the Chinese Pharmacopoeia cannot meet the quality requirements of all preparations, especially the products of spray preparations and injections, because the products of spray preparations and injections are prone to change during the storage period, so there is an urgent need to improve the quality of salbutamol sulfate Standards to ensure that the quality of injections and spray preparations meets the requirements throughout the product cycle