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Application of indole-3-methanol, diindolylmethane and derivatives thereof in drugs used for treating psoriasis

A technology for diindolylmethane and psoriasis, applied in the field of biomedicine, can solve problems such as excessive formation of epidermal horn formation and hyperplasia, and achieve the effects of low price, reduced symptoms, and easy storage and transportation.

Inactive Publication Date: 2015-10-28
ANHUI SIZHENG MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Its pathogenesis is related to many factors such as environment, lesion, diet, etc. Its pathology is mainly manifested as: excessive hyperplasia of epidermal horn formation, inflammatory infiltration, dermal papillary vascular proliferation, and there is no ideal drug treatment for psoriasis at present. , so it is of great significance to find effective therapeutic drugs

Method used

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  • Application of indole-3-methanol, diindolylmethane and derivatives thereof in drugs used for treating psoriasis
  • Application of indole-3-methanol, diindolylmethane and derivatives thereof in drugs used for treating psoriasis
  • Application of indole-3-methanol, diindolylmethane and derivatives thereof in drugs used for treating psoriasis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] (Preparation of 5-chloroindole-3-methanol and 5,5'-dichlorodiindolylmethane)

[0028] Slowly add 0.86ml of phosphorus oxychloride to 2.9ml of dimethylformamide that has been cooled to 0°C in advance. 8.6mmol 5-chloroindole (purchased from Nanjing Ruima Fine Chemical Co., Ltd.) was dissolved in 1.0ml of dimethylformamide, and then slowly added to the aforementioned precooled phosphorus oxychloride solution, the formed suspension was at 37 °C for 60 minutes until the clear yellow solution turns into a light yellow paste. Then 1 ml of ice water was added to this pasty mass, followed by slow addition of 10 ml of an aqueous solution containing 3.75 g of KOH. Heat this mixture to boil and then cool, filter, wash with water, and dry in air to obtain 5-chloroindole-3-acetaldehyde.

[0029]1.0 g of 5-chloroindole-3-acetaldehyde was dissolved in 5.0 ml of methanol, and solid sodium borohydride was continuously added until excess. Then 50ml of water was added to the reactant, c...

Embodiment 2

[0032] (Preparation of 5-nitroindole-3-methanol and 5,5'-dinitrodiindolylmethane)

[0033] 5-Nitroindole can be purchased commercially (Nanjing Ruima Fine Chemical Co., Ltd.). Slowly add 0.92ml of phosphorus oxychloride to 2.9ml of dimethylformamide cooled to 0°C in advance. Dissolve 8.2mmol of 5-nitroindole in 1.0ml of dimethylformamide, then slowly add to the aforementioned pre-cooled phosphorus oxychloride solution, and heat the formed suspension at 42°C for 90 minutes until the clear yellow solution turns Into a light yellow paste substance. Then 1 ml of ice water was added to the pasty mass, followed by slow addition of 10 ml of an aqueous solution containing 3.75 g of KOH. Heat this mixture to boil and then cool, filter, wash with water, and dry in air to obtain 5-nitroindole-3-acetaldehyde.

[0034] 1.0 g of 5-nitroindole-3-acetaldehyde was dissolved in 5.0 ml of methanol, and solid sodium borohydride was continuously added until excess. Then 50ml of water was added...

Embodiment 3

[0037] (Preparation of 5-pentylindole-3-carbinol and 5,5'-dipentyl-diindolylmethane)

[0038] 5-Pentylindole can be purchased commercially (Nanjing Ruima Fine Chemical Co., Ltd.). Slowly add 0.82 ml of phosphorus oxychloride to 2.9 ml of dimethylformamide cooled to 0°C in advance. Dissolve 9.2mmol of 5-pentylindole in 1.0ml of dimethylformamide, then slowly add it to the aforementioned pre-cooled phosphorus oxychloride solution, and heat the formed suspension at 37°C for 40-60 minutes until clear yellow The solution turned into a pale yellow pasty substance. Then 1 ml of ice water was added to the pasty mass, followed by slow addition of 10 ml of an aqueous solution containing 3.75 g of KOH. Heat this mixture to boil and then cool, filter, wash with water, and dry in air to obtain 5-pentylindole-3-acetaldehyde.

[0039] 1.0 g of 5-pentylindole-3-acetaldehyde was dissolved in 5.0 ml of methanol, and solid sodium borohydride was continuously added until excess. Then 50ml of ...

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Abstract

The invention provides application of indole-3-methanol, diindolylmethane and derivatives thereof in drugs used for treating psoriasis. Indole-3-methanol, diindolylmethane and the derivatives thereof can be used for treating psoriasis by inhibiting mitosis of basal cells. Indole-3-methanol, diindolylmethane and the derivatives thereof can effectively mitigate symptoms of psoriasis and can be used as candidate drug molecules for treatment of psoriasis. Meanwhile, micromolecular drugs used in the invention are easily available, low in price, stable in properties and convenient to store and transport, and have wide application prospects.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and more specifically relates to the application of indole-3-carbinol, diindolylmethane and derivatives thereof for treating psoriasis. Background technique [0002] Psoriasis is a disease characterized by chronic scaly skin lesions produced by skin metabolism disorders. Its clinical features are red papules or plaques, and the surface of the skin lesions is covered with silvery-white scales, which can fall off by gently scratching. Because the scales that fall off are white, it is called psoriasis. Its pathogenesis is related to many factors such as environment, lesion, diet, etc. Its pathology is mainly manifested as: excessive hyperplasia of epidermal horn formation, inflammatory infiltration, dermal papillary vascular proliferation, and there is no ideal drug treatment for psoriasis at present. , so it is of great significance to find effective therapeutic drugs. Contents of the invent...

Claims

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Application Information

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IPC IPC(8): A61K31/404A61P17/06
Inventor 张勇
Owner ANHUI SIZHENG MEDICAL TECH
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