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Medical antibacterial dressing and preparation method thereof

A raw material and matrix technology, applied in the field of medical sterilization materials and its preparation, can solve the problems of affecting the effect of use, the color of the wound becomes heavier, etc., and achieve the effects of easy removal, enhanced permeability, and good biological safety

Inactive Publication Date: 2015-10-21
HENAN HUIBO MEDICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, activated carbon fiber will make the wound color heavier during use, which will affect the effect of use

Method used

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  • Medical antibacterial dressing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] The medical antibacterial dressing of this embodiment is made of the following raw materials in parts by weight: 10 parts of matrix, 5 parts of nano zinc oxide, 8 parts of glycerin, 6 parts of penetrant, and 150 parts of purified water.

[0027] The penetrating agent described in this embodiment is a mixture of laurocapram and menthol, wherein 4 parts of laurocapram and 2 parts of menthol. The dosage form of the antibacterial dressing is a gel, and its matrix is ​​a mixture of sodium carboxymethylcellulose and hydroxyethylcellulose.

[0028] The preparation method of the medical antibacterial dressing in this embodiment is to completely dissolve the matrix in purified water, then add nano-zinc oxide, glycerin and penetrant to it, stir evenly with a stirrer, add a regulator to adjust the pH value, and finally remove the air bubbles, That is the finished product.

[0029] The regulator is triethanolamine, and the final pH value of the antibacterial dressing is 6.5. The ...

Embodiment 2

[0031] The medical antibacterial dressing of this embodiment is made of the following raw materials in parts by weight: 8 parts of matrix, 2 parts of nano zinc oxide, 7 parts of glycerin, 5 parts of penetrant, and 120 parts of purified water.

[0032] The penetrant described in this example is laurocaprazine. The dosage form of the antibacterial dressing is a gel, and its matrix is ​​a mixture of sodium carboxymethylcellulose, hydroxyethylcellulose and xanthan gum.

[0033] The preparation method of the medical antibacterial dressing in this embodiment is to completely dissolve the matrix in purified water, then add nano-zinc oxide, glycerin and penetrant to it, stir evenly with a stirrer, add a regulator to adjust the pH value, and finally remove the air bubbles, That is the finished product.

[0034] The regulator is triethanolamine, and the final pH value of the antibacterial dressing is 6.2. The way to remove bubbles is negative pressure defoaming, centrifugal defoaming ...

Embodiment 3

[0036] The medical antibacterial dressing of this embodiment is made of the following raw materials in parts by weight: 5 parts of matrix, 3 parts of nano-zinc oxide, 4 parts of glycerin, 5 parts of penetrant, and 140 parts of purified water.

[0037]The penetrating agent described in this embodiment is menthol. The dosage form of the antibacterial dressing is a gel, and its matrix is ​​a mixture of sodium carboxymethylcellulose and xanthan gum.

[0038] The preparation method of the medical antibacterial dressing in this embodiment is to completely dissolve the matrix in purified water, then add nano-zinc oxide, glycerin and penetrant to it, stir evenly with a stirrer, add a regulator to adjust the pH value, and finally remove the air bubbles, That is the finished product.

[0039] The regulator is triethanolamine, and the final pH value of the antibacterial dressing is 6.8. The way to remove bubbles is negative pressure defoaming, centrifugal defoaming or standing defoamin...

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Abstract

The invention discloses a medical antibacterial dressing, which is composed of the following raw materials in parts by weight: 1 to 53 parts of matrix, 1 to 5 parts of nano zinc oxide, 1 to 10 parts of glycerin, 3 to 7 parts of osmotic agent, and 30 to 350 parts of purified water. The invention further discloses a preparation method of the medical antibacterial dressing. The preparation method comprises the following steps: completely dissolving matrix into purified water, then adding nano zinc oxide, glycerin, and osmotic agent into the water, evenly stirring the solution by a stirrer, adding an adjusting agent to adjust the pH value, and finally removing the bubbles to obtain the finished product. The prepared antibacterial dressing contains a physical nano antibacterial agent (nano zinc oxide), and thus has a strong antibacterial performance; and the inhibition rates on staphylococcus aureus, pseudomonas aeruginosa, and candida albicans are all over 95%. Moreover, the dressing has the advantages of good biological safety and biocompatibility, is capable of promoting the wound healing, does not have any side or toxic effect, and is stable, safe and reliable. The in-vitro cytotoxicity of the dressing is not more than level one.

Description

technical field [0001] The invention belongs to the technical field of medical sterilization material and its preparation, in particular to a medical antibacterial dressing and its preparation method. Background technique [0002] When the normal skin of the human body is injured by abrasions, burns, surgical trauma, etc., it loses its natural protective function, and then the tissue will be infected and other complications due to the invasion and reproduction of microorganisms such as Escherichia coli and Staphylococcus aureus. The use of medical antibacterial dressings can timely control the invasion of microorganisms to infect the wound surface, maintain a slightly humid environment on the wound surface, and promote wound healing. Commonly used antibacterial agents include organic synthetic antibacterial agents, natural antibacterial agents and physical antibacterial gold. Among them, organic synthetic antibacterial agents are rarely used in wound dressings due to their h...

Claims

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Application Information

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IPC IPC(8): A61L15/42A61L15/44A61L15/18A61L15/20
Inventor 朱天钢刘尧张艳琦
Owner HENAN HUIBO MEDICAL CO LTD
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