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Application of ZMYM1 in preparation of Parkinson's disease diagnosis and treatment reagents

The technology of a preparation and a kit is applied in the application field of preparing Parkinson's diagnosis and treatment reagents, which can solve problems such as the inability to meet clinical needs, and achieve the effects of good application prospects, good repeatability and good stability.

Active Publication Date: 2015-10-21
GUAN BOJIAN BIOTECH CO LTD
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  • Abstract
  • Description
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AI Technical Summary

Problems solved by technology

So far, genes related to hereditary PD have been found to include SNCA, LRRK2, DJ-1, PINK-1, Parkin, etc. These pathogenic genes need further research and are far from meeting clinical needs

Method used

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  • Application of ZMYM1 in preparation of Parkinson's disease diagnosis and treatment reagents
  • Application of ZMYM1 in preparation of Parkinson's disease diagnosis and treatment reagents
  • Application of ZMYM1 in preparation of Parkinson's disease diagnosis and treatment reagents

Examples

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Embodiment 1

[0028] Example 1 High-throughput sequencing and analysis

[0029] The samples came from Peking Union Medical College Hospital, and the informed consent of the subjects was obtained. Collect peripheral blood samples from 15 patients with Parkinson's disease and 9 samples from healthy controls for RNA extraction. After RNA extraction, agarose gel electrophoresis is performed. From the results of electrophoresis, it can be preliminarily judged whether the quality of the extracted RNA samples is qualified or not. for further transcriptome analysis. Then, the extraction of RNA samples was detected by NanoDrop1000 spectrophotometer, and the sample requirements for RNA-seq sequencing: OD260 / OD280 was 1.8-2.2.

[0030] The sequencing platform is the HiSeq 2500 high-throughput sequencing platform of Illumina, which performs high-throughput transcriptome deep sequencing. After sequencing, we use Fast-QC (http: / / www.bioinformatics.babraham.ac.uk / projects / fastqc / ) The software evaluates...

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Abstract

The invention relates to an application of ZMYM1 in the preparation of Parkinson's disease diagnosis and treatment reagents. Candidate gene ZMYM1 is chosen after gene screening through adopting bioinformatics method analysis based on a high-flux sequencing result, and molecular biology experiments confirm that the ZMYM1 gene has very good correlation with the Parkinson's disease, so the ZMYM1 gene can be used in the preparation of auxiliary diagnosis and treatment preparations of the Parkinson's disease, and has important clinic application values.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to the application of ZMYM1 in the preparation of reagents for Parkinson's diagnosis and treatment. Background technique [0002] Parkinson's disease (Parkinson's disease, PD) is a chronic progressive disease that is currently incurable. It was first described by the British Parkinson in 1817. With the progress of research on PD, we have a deeper understanding of this disease. It is clinically manifested as motor symptoms such as resting tremor, bradykinesia, muscle rigidity, and posture and gait disturbance, and non-motor symptoms such as constipation, sleep disturbance, and mental and behavioral abnormalities. At present, the pathogenesis of PD is still unclear, and it may be related to genetic factors, mitochondrial dysfunction, oxidative stress, immune abnormalities, cell apoptosis, and environmental factors. In PD, about 10% of patients are familial PD patients with obvious genetic ...

Claims

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Application Information

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IPC IPC(8): A61K48/00A61K38/17A61K45/00A61P25/16C12Q1/68G01N33/68G01N33/58G01N33/577
Inventor 杨承刚宋宏涛
Owner GUAN BOJIAN BIOTECH CO LTD
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