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Polyvinyl alcohol composition

A technology of polyvinyl alcohol and composition, which is applied in the field of ophthalmic drugs, can solve problems such as the need to improve the effect of eye drops, increase the mixing time and labor costs, and unfavorable use by consumers, so as to restore the epithelial cell barrier and improve the curative effect. Significant and good antibacterial and antibacterial effect

Active Publication Date: 2015-10-21
泊诺(天津)创新医药研究有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since this polyvinyl alcohol eye drop does not add preservatives, antibacterial agents, etc., after opening, it needs to be used up at one time, which increases the cost and is not conducive to consumer use.
[0003] In addition, due to the addition of polyvinylpyrrolidone in this product, in the production process, the raw material of polyvinylpyrrolidone is prone to agglomeration. When dissolving, it must be added slowly while stirring, and then continue to stir until it is completely dissolved. Therefore, the blending time is increased. and labor costs
In addition, the effect of the eye drops needs to be improved

Method used

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  • Polyvinyl alcohol composition
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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] The polyvinyl alcohol composition is made into eye drops, and the specific steps are as follows:

[0042] Add 8 g of polyvinyl alcohol, 0.1 g of polyvinyl pyrrolidone, 0.5 g of xanthan gum and 0.5 g of fatty alcohol ester to 150 ml of water for injection, and mix well to obtain the first mixed solution;

[0043] Then add sodium chloride and sodium dihydrogen phosphate, adjust the osmotic pressure of the solution to be 300mOsm / L, and the pH value is 7.5 to obtain the target mixed solution;

[0044] After the target mixture is filtered and sterilized, it can be dispensed.

[0045] Group 2: Ultrasonic the obtained target mixture for 30 minutes, the power used for the ultrasonic wave is 5W; then filter and sterilize it, and dispense it.

Embodiment 2

[0047] The polyvinyl alcohol composition is made into eye drops, and the specific steps are as follows:

[0048]Add 15g of polyvinyl alcohol, 0.5g of polyvinylpyrrolidone, 5g of xanthan gum and 3g of sucrose ester to 200ml of water for injection, and mix well to obtain the first mixed solution;

[0049] Then add sodium sulfate and disodium hydrogen phosphate, adjust the osmotic pressure of the solution to be 310mOsm / L, and the pH value is 7.2 to obtain the target mixed solution;

[0050] Group 1: The target mixture is sterilized by filtration and then subpackaged.

[0051] Group 2: Ultrasonic the obtained target mixture for 10 minutes, the power used for the ultrasonic wave is 10W; then filter and sterilize it, and then dispense it.

Embodiment 3

[0053] The polyvinyl alcohol composition is made into eye drops, and the specific steps are as follows:

[0054] Add 10g of polyvinyl alcohol, 0.2g of polyvinylpyrrolidone, 1g of xanthan gum, 0.5g of fatty alcohol ester and 0.5g of sucrose ester to 170ml of water for injection, and mix well to obtain the first mixed solution;

[0055] Add potassium nitrate and potassium carbonate then, adjust the osmotic pressure of solution to be 305mOsm / L, pH value is 7.0, obtains target mixed solution;

[0056] Group 1: The target mixture is sterilized by filtration and then subpackaged.

[0057] Group 2: Ultrasonic the obtained target mixture for 25 minutes, the power used for the ultrasonic wave is 7W; then filter and sterilize it, and then dispense it.

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Abstract

The invention relates to the field of ophthalmic drugs, in particular to a polyvinyl alcohol composition, which is mainly prepared by following raw materials in parts by weight: 8-15 parts of polyvinyl alcohol, 0.1-0.5 part of polyvinylpyrrolidone, 0.5-5 parts of xanthan gum and 0.5-3 parts of nonionic surfactant. According to the polyvinyl alcohol composition, the polyvinyl alcohol, polyvinylpyrrolidone, xanthan gum and nonionic surfactant are specifically selected for match usage, a moisturizing action is enhanced, action time thereof in eyes is prolonged, healing of corneal epithelial cells is better promoted, an epithelial cell barrier is recovered, a treatment effect is improved, a finally obtained preparation is stable in performance and high in use comfortable level, and has obvious treatment effect for dry eyes, eyestrain and the like. In the preparation process, respective raw materials are directly mixed in water, and matched with one another, and the defect that polyvinylpyrrolidone is easily caked is overcome.

Description

technical field [0001] The invention relates to the field of ophthalmic medicines, in particular to a polyvinyl alcohol composition. Background technique [0002] Existing polyvinyl alcohol eye drops mainly contain polyvinyl alcohol, polyvinylpyrrolidone, sodium chloride and water for injection, which are used as a lubricant to prevent or treat dry eyes, foreign body sensation, eye fatigue, etc. Symptoms of irritation or improvement of dryness of the eyes. Since this polyvinyl alcohol eye drop does not add preservatives, antibacterial agents, etc., after opening, it needs to be used up at one time, which increases the cost and is not conducive to consumer use. [0003] In addition, due to the addition of polyvinylpyrrolidone in this product, in the production process, the raw material of polyvinylpyrrolidone is prone to agglomeration. When dissolving, it must be added slowly while stirring, and then continue to stir until it is completely dissolved. Therefore, the blending ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/489A61K31/79A61K47/14A61P27/02A61K31/045A61K31/765
Inventor 沈载宽郑林海
Owner 泊诺(天津)创新医药研究有限公司
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