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Apparatus and method for rapidly measuring sulfur dioxide residue level in Chinese herb

A technology for quantitative determination of sulfur dioxide, which is applied in the preparation of test samples, material excitation analysis, color/spectral property measurement, etc.

Active Publication Date: 2015-10-14
HEBEI UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The main purpose of the present invention is to overcome above-mentioned deficiencies in the prior art, establish a kind of highly specific, high-sensitivity alkali titration-fluorescence spectrometry combined method for measuring the sulfur dioxide residual amount in Chinese herbal medicine, mainly solve existing measuring method determination Inaccurate results etc.

Method used

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  • Apparatus and method for rapidly measuring sulfur dioxide residue level in Chinese herb
  • Apparatus and method for rapidly measuring sulfur dioxide residue level in Chinese herb
  • Apparatus and method for rapidly measuring sulfur dioxide residue level in Chinese herb

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Determination of the content of sulfur dioxide in Asparagus, the steps are:

[0038] a. Standard curve: In the reaction cell, add 3mL sodium hydroxide solution with a concentration of 5g / L respectively, and then inject and draw 0.0, 0.1, 0.3, 0.5, 0.7, 0.9, 1.1, 1.3, 1.5mL of 130mg· L -1 Sodium sulfite solution, and at the same time, 380mg·L -1 Ammonium acetate solution 2mL, and after diluting to 10mL with pure water, slowly add 134mg·L dropwise under stirring -1 3mL of o-phthalaldehyde solution, stirred ultrasonically at 70°C for 20min, cooled to room temperature, added pure water to make up to 25mL; poured into a 1cm cuvette after passing through the membrane respectively, measured the absorbance A at a wavelength of 354nm, and plotted the concentration and absorbance A The standard curve is shown in the appendix figure 1 ), get the regression equation: A=87.03+517.32X, R 2 = 0.998.

[0039] b. Sample determination: put accurately weighed 100mg of Chinese herbal ...

Embodiment 2

[0048] Determination of the content of sulfur dioxide in Fritillaria fritillata, the steps are:

[0049] Accurately weighed 100 mg of a commercially available Fritillaria fritillary sample that was pulverized uniformly, and the sample treatment and other operations were the same as in Example 1. The sample was injected into a 1 cm cuvette through the film, and the absorbance was measured at a wavelength of 354 nm to be 308.315.

[0050] Calculate the amount of sulfur dioxide in the sample:

[0051] ΔX = A - 87.03 517.32 × W × 10 6 = 308.315 - 87.03 517.32 × 100 × 10 6 = 4.28 × ...

Embodiment 3

[0054] Determination of the content of sulfur dioxide in Poria cocos, the steps are:

[0055] Accurately weigh 50 mg of commercially available Poria cocos sample that is pulverized uniformly, sample treatment and other operations are the same as in Example 1, the sample is injected into a 1 cm cuvette through the membrane, and the absorbance measured at a wavelength of 354 nm is 262.846.

[0056] Calculate the amount of sulfur dioxide in the sample:

[0057] ΔX = A - 87.03 517.32 × W × 10 6 = 262.846 - 87.03 517.32 × 100 × 10 6 = 6 . 80 × 10 ...

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Abstract

The invention relates to an apparatus and a method for rapidly measuring the sulfur dioxide residue level in a Chinese herb, and belongs to the technical field of drug analysis. The method comprises: a, drawing a standard curve and deriving a calculation formula; b, directly detecting the Chinese herb without treatment; and c, calculating the result. The apparatus comprises a purified water bottle, a sodium hydroxide solution bottle, an o-phthalaldehyde solution bottle, an ammonium acetate solution bottle, a sodium sulfite solution bottle, a multi-channel micro-flow-controlled peristaltic pump, a reaction pool, an ultrasound instrument, a micro-flow-controlled peristaltic pump, a serpentine condensation pipe, a filtration membrane, a cuvette, a detector, and a workstation. The method has characteristics of simple equipment, simple operation, accurate detection result, and effective detection of sulfur dioxide in the Chinese herb.

Description

technical field [0001] The invention relates to the technical field of detection of sulfur dioxide in Chinese medicinal materials, in particular to a device and method for measuring sulfur dioxide in Chinese medicinal materials, belonging to the technical field of drug analysis. Background technique [0002] Sulfur dioxide residues in Chinese herbal medicines mainly exist in the form of free and bound states, and the free states include bisulfite (HSO 3 - ), SO 2 molecules and sulfites (SO 3 2- ), and easily form various forms of combined sulfur dioxide residues with reducing sugars, proteins, pigments, enzymes, vitamins, aldehydes, ketones, etc. in medicinal materials. Since irreversibly bound sulfite does not dissociate under physiological conditions and will not cause harm to human health, the detection objects of sulfur dioxide or sulfite are generally free sulfite and reversibly bound sulfite. [0003] Although the 2010 edition of "Chinese Pharmacopoeia" adds a met...

Claims

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Application Information

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IPC IPC(8): G01N21/33G01N1/38G01N21/64
Inventor 郑玉光马东来李菁康立英王靓吴枭吴迪温子帅
Owner HEBEI UNIV OF CHINESE MEDICINE
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